Cell Regulation & Trafficking Lab

 

 

Dr.ParthaprasadChattopadhyay,Professor

Address: Room No. 4007, Convergence Block, AIIMS, New Delhi.

Phone:011-26549238

Email: This email address is being protected from spambots. You need JavaScript enabled to view it.

 

 

EDUCATION

MBBS,(1981-1987) R G Kar Medical College, Calcutta University, Kolkata

MD,Biochemistry,(1989-1991) All India Institute of Medical Sciences, New Delhi.

PhD, Biochemistry (1992-1996) All India Institute of Medical Sciences, New Delhi. 

 

PROFESSIONAL EXPERIENCE

Senior Demonstrator (1992-1995) Department of Biochemistry, AIIMS, New Delhi Assistant Professor (1997-2003) Department of Biochemistry, AIIMS, New Delhi Associate Professor (2003-2007) Department of Biochemistry, AIIMS, New Delhi Additional Professor (2007-2011) Department of Biochemistry, AIIMS, New Delhi Professor (2011- till date) Department of Biochemistry, AIIMS, New Delhi

 

Research Focus of the Lab

1. Nanoparticle trafficking within the cell: Tracing the path of nanoparticles within the cell and attempting to modulate their intracellular travel to prolong their stay within the cell for increased unloading of their cargo (drug).

2. Site-directed epigenetic modulation: Using modified CRISPR based techniques to modulate CpG methylation and Histone methylation/acetylation for altering gene expression of tumor suppressor and promoter genes

  

Present Team

1. PhDStudent(s):RitikaSingh

2. MDstudent(s):Dr.ISanjana 

 

Strategic publications

1. Poly(lactic-co-glycolic)  acidna  noparticles localize in vesicles after diffusing into  cells and  are   retained by intracellular traffic modulators. Singh N, Mudassir M,Ansari S, Chosdol K, Sinha S, Chattopadhyay P. Nanomedicine (Lond). 2023Nov;18(26):1907-1919.

2. Targeting CXCR4-expressing Cancer Cells withAvidin-poly (lactic-co-glycolic acid) Nanoparticle Surface Modified withBiotinylatedDV1  Peptide.AnsariS,MudassirM,VijayalekshmiB,ChattopadhyayP.IntJApplBasicMedRes.2023Apr-Jun;13(2):106-112.

3. Passive  internalization and active extrusiondetermines PLGA-nanoparticlecon centration in cancer cell lines. BaidyaG,Tiwary R, Mudassir M, Singh N, Saha S, Chosdol K, Sinha S, Chattopadhyay P..Nanomedicine (Lond). 2020Aug;15(23):2229-2239.

4. HIF-2α mediates a marked increase in migration and stemness characteristics in a subset of glioma cells under hypoxia byactivatingan Oct-4/Sox-2-Mena(INV)axis.BhagatM,PalanichamyJK,RamalingamP,MudassirM,IrshadK,ChosdolK,Sarkar C, Seth P, Goswami S, Sinha S, Chattopadhyay P..Int J Biochem Cell Biol. 2016 May;74:60-71.

5. Anovel placental like alkaline phosphatase promoter driven transcriptional silencing combined with single chain variablefragmentantibodybasedvirosomaldeliveryforneoplasticcelltargeting.KhanI,ZakariaMK,KumarM,ManiP,ChattopadhyayP, Sarkar DP, Sinha S..J Transl Med. 2015 Aug 5;13:254.

6. GeneSilencingandActivationofHumanPapillomavirus18IsModulatedbySense PromoterAssociatedRNAinBidirectionallyTranscribed Long Control Region. Kassab MA, Mudassir M, SinghA, Bhagat M, Palanichamy JK, Ramalingam P, Chosdol K,Sinha S, Chattopadhyay P..PLoS One. 2015 Jun 5;10(6):e0128416.

7. BiogenesisofintronicmiRNAslocatedinclustersbyindependenttranscriptionandalternativesplicing.RamalingamP,Palanichamy JK, SinghA, Das P, Bhagat M, Kassab MA, Sinha S, Chattopadhyay P. RNA. 2014 Jan;20(1):76-87.

8. Combination of hepatocyte specific delivery and transformation dependent expression of shRNAinducing transcriptional genesilencingofc-Mycpromoterinhepatocellularcarcinomacells.ZakariaMK,KhanI,ManiP,ChattopadhyayP,SarkarDP,SinhaS..BMC Cancer. 2014 Aug 10;14:582. doi: 10.1186/1471-2407-14-582.

9. Long-termsuppressionofHIV-1CvirusproductioninhumanperipheralbloodmononuclearcellsbyLTRheterochromatizationwith a short double-stranded RNA. SinghA, Palanichamy JK, Ramalingam P, Kassab MA, Bhagat M,Andrabi R, Luthra K,Sinha S, Chattopadhyay P..J Antimicrob Chemother. 2014 Feb;69(2):404-15.

10. CpGhypermethylationoftheC-mycpromoterbydsRNAresultsingrowthsuppression.MehndirattaM,PalanichamyJK, PalA,Bhagat M, SinghA, Sinha S, Chattopadhyay P..Mol Pharm. 2011 Dec 5;8(6):2302-9.

11. Silencing of integrated human papillomavirus-16 oncogenes by small interfering RNA-mediated heterochromatization. PalanichamyJK, MehndirattaM, Bhagat M,RamalingamP,Das B,DasP,Sinha S,ChattopadhyayP..Mol Cancer Ther. 2010 Jul;9(7):2114-22.

12. Aberrant methylation and associated transcriptional mobilization ofAlu elements contributes to genomic instability in hypoxia.Pal A,SrivastavaT,SharmaMK,MehndirattaM,DasP,SinhaS,ChattopadhyayP..JCellMolMed.2010Nov;14(11):2646-54..

Funding Agencies

Department of Biotechnology and Department of Science & Technology, Ministry of Science & Technology, GOI.