Dr. Parthaprasad Chattopadhyay
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Cell Regulation & Trafficking Lab
Dr.ParthaprasadChattopadhyay,Professor
Address: Room No. 4007, Convergence Block, AIIMS, New Delhi.
Phone:011-26549238
Email: This email address is being protected from spambots. You need JavaScript enabled to view it.
EDUCATION
MBBS,(1981-1987) R G Kar Medical College, Calcutta University, Kolkata
MD,Biochemistry,(1989-1991) All India Institute of Medical Sciences, New Delhi.
PhD, Biochemistry (1992-1996) All India Institute of Medical Sciences, New Delhi.
PROFESSIONAL EXPERIENCE
Senior Demonstrator (1992-1995) Department of Biochemistry, AIIMS, New Delhi Assistant Professor (1997-2003) Department of Biochemistry, AIIMS, New Delhi Associate Professor (2003-2007) Department of Biochemistry, AIIMS, New Delhi Additional Professor (2007-2011) Department of Biochemistry, AIIMS, New Delhi Professor (2011- till date) Department of Biochemistry, AIIMS, New Delhi
Research Focus of the Lab
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Nanoparticle trafficking within the cell: Tracing the path of nanoparticles within the cell and attempting to modulate their intracellular travel to prolong their stay within the cell for increased unloading of their cargo (drug).
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Site-directed epigenetic modulation: Using modified CRISPR based techniques to modulate CpG methylation and Histone methylation/acetylation for altering gene expression of tumor suppressor and promoter genes
Present Team
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PhDStudent(s):RitikaSingh
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MDstudent(s):Dr.ISanjana
Strategic publications
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Poly(lactic-co-glycolic) acidna noparticles localize in vesicles after diffusing into cells and are retained by intracellular traffic modulators. Singh N, Mudassir M,Ansari S, Chosdol K, Sinha S, Chattopadhyay P. Nanomedicine (Lond). 2023Nov;18(26):1907-1919.
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Targeting CXCR4-expressing Cancer Cells withAvidin-poly (lactic-co-glycolic acid) Nanoparticle Surface Modified withBiotinylatedDV1 Peptide.AnsariS,MudassirM,VijayalekshmiB,ChattopadhyayP.IntJApplBasicMedRes.2023Apr-Jun;13(2):106-112.
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Passive internalization and active extrusiondetermines PLGA-nanoparticlecon centration in cancer cell lines. BaidyaG,Tiwary R, Mudassir M, Singh N, Saha S, Chosdol K, Sinha S, Chattopadhyay P..Nanomedicine (Lond). 2020Aug;15(23):2229-2239.
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HIF-2α mediates a marked increase in migration and stemness characteristics in a subset of glioma cells under hypoxia byactivatingan Oct-4/Sox-2-Mena(INV)axis.BhagatM,PalanichamyJK,RamalingamP,MudassirM,IrshadK,ChosdolK,Sarkar C, Seth P, Goswami S, Sinha S, Chattopadhyay P..Int J Biochem Cell Biol. 2016 May;74:60-71.
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Anovel placental like alkaline phosphatase promoter driven transcriptional silencing combined with single chain variablefragmentantibodybasedvirosomaldeliveryforneoplasticcelltargeting.KhanI,ZakariaMK,KumarM,ManiP,ChattopadhyayP, Sarkar DP, Sinha S..J Transl Med. 2015 Aug 5;13:254.
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GeneSilencingandActivationofHumanPapillomavirus18IsModulatedbySense PromoterAssociatedRNAinBidirectionallyTranscribed Long Control Region. Kassab MA, Mudassir M, SinghA, Bhagat M, Palanichamy JK, Ramalingam P, Chosdol K,Sinha S, Chattopadhyay P..PLoS One. 2015 Jun 5;10(6):e0128416.
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BiogenesisofintronicmiRNAslocatedinclustersbyindependenttranscriptionandalternativesplicing.RamalingamP,Palanichamy JK, SinghA, Das P, Bhagat M, Kassab MA, Sinha S, Chattopadhyay P. RNA. 2014 Jan;20(1):76-87.
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Combination of hepatocyte specific delivery and transformation dependent expression of shRNAinducing transcriptional genesilencingofc-Mycpromoterinhepatocellularcarcinomacells.ZakariaMK,KhanI,ManiP,ChattopadhyayP,SarkarDP,SinhaS..BMC Cancer. 2014 Aug 10;14:582. doi: 10.1186/1471-2407-14-582.
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Long-termsuppressionofHIV-1CvirusproductioninhumanperipheralbloodmononuclearcellsbyLTRheterochromatizationwith a short double-stranded RNA. SinghA, Palanichamy JK, Ramalingam P, Kassab MA, Bhagat M,Andrabi R, Luthra K,Sinha S, Chattopadhyay P..J Antimicrob Chemother. 2014 Feb;69(2):404-15.
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CpGhypermethylationoftheC-mycpromoterbydsRNAresultsingrowthsuppression.MehndirattaM,PalanichamyJK, PalA,Bhagat M, SinghA, Sinha S, Chattopadhyay P..Mol Pharm. 2011 Dec 5;8(6):2302-9.
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Silencing of integrated human papillomavirus-16 oncogenes by small interfering RNA-mediated heterochromatization. PalanichamyJK, MehndirattaM, Bhagat M,RamalingamP,Das B,DasP,Sinha S,ChattopadhyayP..Mol Cancer Ther. 2010 Jul;9(7):2114-22.
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Aberrant methylation and associated transcriptional mobilization ofAlu elements contributes to genomic instability in hypoxia.Pal A,SrivastavaT,SharmaMK,MehndirattaM,DasP,SinhaS,ChattopadhyayP..JCellMolMed.2010Nov;14(11):2646-54..
Funding Agencies
Department of Biotechnology and Department of Science & Technology, Ministry of Science & Technology, GOI.