Dr. Jyotirmoy Banerjee

Dr Jyotirmoy Banerjee

 

Current Designation & Contact Details: 

Additional Professor

Room No. 11, 5^th Floor,

Porta Cabin, Teaching Block

Department of Biophysics,

All India Institute of Medical Sciences (AIIMS), New Delhi, India

Tel: 91-11-26549324

e-mail: यह ईमेल पता spambots से संरक्षित किया जा रहा है. आप जावास्क्रिप्ट यह देखने के सक्षम होना चाहिए.

यह ईमेल पता spambots से संरक्षित किया जा रहा है. आप जावास्क्रिप्ट यह देखने के सक्षम होना चाहिए.

 

Recent Employment Details: 

July 2023-Till Date

Additional Professor, Department of Biophysics, All India Institute of Medical Sciences (AIIMS), New Delhi, India. 

 

July 2020-June 2023

Associate Professor, Department of Biophysics, All India Institute of Medical Sciences (AIIMS), New Delhi, India. 

 

May 2017-June 2020

Assistant Professor, Department of Biophysics, All India Institute of Medical Sciences (AIIMS), New Delhi, India.

 

Brief Area of Research: 

Cellular electrophysiological studies to understand function of ion channels of central nervous system and investigating regulation of synaptic transmission in drug-resistant epilepsy pathologies at cellular and molecular level.

 

Recent Selected Publications (*As Corresponding Author): 

Google scholar link: https://scholar.google.com/citations?user=81uRX7kAAAAJ&hl=en

1. Kumar AJ, Nambiar S, Sharma A, Tripathi M, Sarat Chandra P, Dixit AB, Siraj F, Banerjee J*.Altered AMPA receptor subunit configuration contributes to dysfunctional excitatory synaptic activity in BCNU rat-model of focal cortical dysplasia (FCD). 2026, Brain Research, 1884:150313. doi: 10.1016/ j.brainres.2026.150313

2. Aggarwal Y, Dixit AB, Siraj F, Tripathi M, Chandra PS, Banerjee J*. Differential regulation of GABA_A receptor-mediated hyperexcitability at different stages of brain development in focal cortical dysplasia (FCD). 2025, Experimental Neurology, 389:115265. doi: 10.1016/j.expneurol.2025.115265

3. Srivastava A, Agarwal Y, Dey S, Doddamani S, Sharma MC, Tripathi M, Chandra PS, Lalwani S, Dixit AB, Banerjee J*. Dysregulation of miR‑24‑3p and miR‑186‑5p and GABA_A receptor expression in focal cortical dysplasia. 2025, Acta Neurobiologiae Experimentalis, 85, 16-28. doi:10.55782/ane-2024-2656

4. Aggarwal Y, Dixit AB, Tripathi M, Doddamani R, Sharma MC, Chandra PS, Banerjee J*. Action potential-dependent α4-containing GABAA receptors contribute to epileptogenicity in focal cortical dysplasia. 2025, Epilepsy Research, 210:107520. doi: 10.1016/j.eplepsyres.2025.107520.

5. Yadav N, Anand S, Kumar K, Doddamani R, Tripathi M, Chandra PS, Lalwani S, Sharma MC, Banerjee J*, Dixit AB*. Pathology-specific lipid alterations with triacylglycerol as a potential biomarker in Focal cortical dysplasia (FCD) and Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis (MTLE-HS). 2025, Neuroscience, 566:72-86. doi: 10.1016/j.neuroscience.2024.12.038.

6. Srivastava A, Rajput P, Tripathi M, Chandra PS, Doddamani R, Sharma MC, Lalwani S, Banerjee J*, Dixit AB*. Integrated Proteomics and Protein Co-expression Network Analysis Identifies Novel Epileptogenic Mechanism in Mesial Temporal Lobe Epilepsy. 2024, Molecular Neurobiology, 61:9663-9679. doi: 10.1007/s12035-024-04186-5

7. Aggarwal Y, Vaid A, Visani A, Rane RS, Joseph A, Mukherjee S, Tripathi M, Chandra PS, Doddamani R, Dixit A, Banerjee J*. Cold Atmospheric Plasma (CAP) treatment increased Reactive Oxygen and Nitrogen Species (RONS) levels in tumor samples obtained from patients with low-grade glioma. 2024, Biomedical Physics & Engineering Express, 10: 025018. doi: 10.1088/2057-1976/ad20a9

8. Dubey V, Roy A, Dixit AB, Tripathi M, Pandey S, Jian S, Chandra PS, Banerjee J*. Dendritic reorganization in the hippocampus, anterior temporal lobe, and frontal neocortex of lithium-pilocarpine induced Status Epilepticus (SE). 2023, Journal of Chemical Neuroanatomy, 133: 102319. doi: 10.1016/j.jchemneu.2023.102329.

9. Kumar K, Dubey V, Zaidi SS, Tripathi M, Siraj F, Sharma MC, Chandra PS, Doddamani R, Dixit AB, Banerjee J*. RNA Sequencing of Intraoperative Peritumoral Tissues Reveals Potential Pathways Involved in Glioma-Related Seizures. 2023, Journal of Molecular Neuroscience, 73:437-447. doi: 10.1007/s12031-023-02125-y.

10. Sharma D, Tripathi M, Doddamani R, Sharma MC, Lalwani S, Chandra PS, Dixit AB, Banerjee J*. Correlation of Age at Seizure Onset with GABA_A receptor subunit and Chloride Co-transporter configuration in Focal Cortical Dysplasia (FCD). 2023, Neuroscience Letters, 796: 137065. doi: 10.1016/j.neulet.2023.137065.

11. Chakraborty A, Dey S, Kumar K, Dixit AB, Tripathi M, Sharma MC, Chandra PS, Banerjee J*. Novel variants in GABA_A receptor subunits: A possible association with benzodiazepine resistance in patients with drug-resistant epilepsy. 2023, Epilepsy Research, 189:107056. doi: 10.1016/j.eplepsyres.2022.107056.

12. Dey S, Dubey V, Dixit AB, Tripathi M, Chandra PS, Banerjee J*. Differential Levels of Tryptophan-Kynurenine Pathway Metabolites in the Hippocampus, Anterior Temporal Lobe, and Neocortex in an Animal Model of Temporal Lobe Epilepsy. 2022, Cells, 11:3560. doi: 10.3390/cells11223560.

13. Kumar K, Banerjee Dixit A, Tripathi M, Dubey V, Siraj F, Sharma MC, Lalwani S, Chandra PS, Banerjee J*. Transcriptomic profiling of nonneoplastic cortical tissues reveals epileptogenic mechanisms in dysembryoplastic neuroepithelial tumors. 2022, Functional & Integrative Genomics; 22:905-917. doi: 10.1007/s10142-022-00869-1.

14. Bera A, Srivastava A, Dubey V, Dixit AB, Tripathi M, Sharma MC, Lalwani S, Chandra PS, Banerjee J*. Altered hippocampal expression and function of cytosolic phospholipase A2 (cPLA2) in temporal lobe epilepsy (TLE). 2022, Neurological Research; 44: 748-753.doi: 10.1080/01616412.2022.2051131.

15. Dubey V, Dey S, Dixit AB, Tripathi M, Chandra PS, Banerjee J*. Differential glutamate receptor expression and function in the hippocampus, anterior temporal lobe and neocortex in a pilocarpine model of temporal lobe epilepsy. 2022, Experimental Neurology;347:113916. doi: 10.1016/j.expneurol.2021.113916.

16. Dey S, Banerjee Dixit A, Tripathi M, Doddamani RS, Sharma MC, Lalwani S, Chandra PS, Banerjee J*. Altered hippocampal kynurenine pathway metabolism contribute to hyperexcitability in human mesial temporal lobe epilepsy-hippocampal sclerosis. 2021, British Journal of Pharmacology; 178:3959-3976. doi: 10.1111/bph.15534.

17. Kumar S, Shanker OR, Kumari N, Tripathi M, Chandra PS, Dixit AB, Banerjee J*. Neuromodulatory effects of SARS-CoV2 infection: Possible therapeutic targets. 2021, Expert Opinion on Therapeutic Targets; 25:509-519.doi: 10.1080/14728222.2021.1953475.

18. Banerjee J, Srivastava A, Sharma D, Dey S, Tripathi M, Sharma MC, et al. Differential regulation of glutamatergic activity in the hippocampus and anterior temporal lobe by cyclin dependent kinase 5 (Cdk5) in mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE-HS). 2021, Neuroscience Letters; 761: 136096. doi: 10.1016/j.neulet.2021.136096.

19. Dey S, Doddamani R, Dixit AB, Tripathi M, Sharma MC, Chandra PS, Banerjee J*. Altered spontaneous glutamatergic and GABAergic activity in the peritumoral cortex of low-grade gliomas presenting with history of seizures. 2021, Frontiers in Neuroscience; 15:689769. doi:10.3389/fnins.2021.689769

20. Sharma D, Dixit AB, Dey S, Tripathi M, Doddamani R, Sharma MC, Lalwani S, Gurjar HK, Chandra PS, Banerjee J*. Increased levels of α4-containing GABA_A receptors in focal cortical dysplasia: A possible cause of benzodiazepine resistance. 2021, Neurochemistry International; 148:105084.doi: 10.1016/j.neuint.2021.105084

21. Banerjee J*, Dey S, Dixit AB, Doddamani R, Sharma MC, Garg A, et al. GABA_A Receptor-Mediated Epileptogenicity in Focal Cortical Dysplasia (FCD) Depends on Age at Epilepsy Onset. 2020, Front Cell Neurosci; 14:562811.doi: 10.3389/fncel.2020.562811

22. Banerjee J*, Dey S, Dixit AB, Tripathi M, Doddamani R, Sharma MC, et al. α7 nicotinic receptors contributes to glutamatergic activity in the hippocampus of patients with mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE-HS). 2020, J Neural Transmission; 127:1441-1446.doi: 10.1007/s00702-020-02239-2.

23. Srivastava A, Dixit AB, Paul D, Tripathi M, Sarkar C, Chandra PS, Banerjee J* (2017). Comparative analysis of cytokine/chemokine regulatory networks in patients with hippocampal sclerosis (HS) and focal cortical dysplasia (FCD). Scientific Reports, 7:15904.doi: 10.1038/s41598-017-16041-w

24. Banerjee J*, Dixit AB, Srivastava A, Ramanujam B, Kakkar A, Sarkar C, Tripathi M & Chandra PS (2017). Altered glutamatergic tone reveals two distinct resting state networks at the cellular level in hippocampal sclerosis. Scientific Reports, 7:319.doi: 10.1038/s41598-017-00358-7.

 

Selected ongoing research projects:

1. Grant entitled "Deciphering the contribution of proestrous-estrous transition to seizure susceptibility in drug resistant epilepsy pathologies". Department of Biotechnology (DBT), Ministry of Science & Technology, Govt of India.

2. Grant entitled “Modulators of α4-containing GABA_A receptors: Potential therapy for focal cortical dysplasia (FCD)” Investigator-Initiated Research Proposals (IIRP) from Indian Council of Medical Research (ICMR), India

3. Grant entitled "Calcium permeable ion channels as therapeutic targets to manage chronic pain". Department of Biotechnology (DBT), Ministry of Science & Technology, Govt of India.

4. Grant entitled “Deciphering the role of platelets in drug resistant epilepsy”. Adhoc Grant from Indian Council of Medical Research (ICMR), India.

 

Recent Awards: 

• AIIMS Excellence Research Award in Basic Sciences for the year 2024.

• AIIMS Oncology Research Award in Basic Sciences for the year 2023.

• AIIMS Oncology Research Award in Basic Sciences for the year 2022.

• AIIMS Excellence Research Award in Basic Sciences for the year 2021.

• AIIMS Excellence Research Award in Basic Sciences for the year 2020. 

 

	I am currently pursuing PhD, with an academic background in biotechnology. Currently, I am exploring various platelet mediated mechanisms in Drug resistance epilepsy, with particular emphasis on alteration in synaptic activity. My goal is to develop an adjunctive therapy that can help achieve seizure freedom or reduce seizure burden, ultimately improving quality of life in patients with DRE.
	I am a Ph.D. scholar and a CSIR Fellow. My study focuses on focal cortical dysplasia (FCD) in drug-resistant epilepsy and how NLRP3 inflammasome-mediated pyroptosis disrupts GABAA receptor function in it. I aim to understand neuroinflammation's impact on inhibitory neurotransmission and identify therapeutic targets.
	I am a Ph.D. scholar and a CSIR fellow. My current work focuses on investigating the role of platelet-derived extracellular vesicles (PEVs) in synaptic activity underlying drug-resistant epilepsy (DRE) pathologies, to uncover novel mechanistic insights and potential therapeutic targets.
	I am a PhD student with a Master’s degree in Biomedical Science. My research focuses on the regulation of glutamate receptor function in neuropathic pain. I am investigating how molecular and neuroinflammatory mediators interact to modulate glutamatergic excitatory activity in the central nervous system and drive neuropathic pain.
	I am a Senior Research Fellow with a Master’s degree in Neuroscience. Currently, I am investigating how fluctuations in steroidal hormones affect seizure susceptibility in female rat models of drug-resistant epilepsy pathologies. To address these questions, I use electrophysiological and molecular approaches to uncover the underlying mechanisms.
	I am a MSc student. My research focuses on the crosstalk between alpha‑7 nicotinic receptors and glutamatergic receptor activity in neuropathic pain. I aim to understand how this interaction modulates pain signalling and contributes to the underlying mechanisms of neuropathic pain.

Recent Student Awards:

Dr. Arun J Kumar won the 1^st Prize at Poster Presentation in Junior Residents Category on 5^th Research Day, AIIMS New Delhi, the title of hid study was Altered AMPA Receptor Configuration Drives Synaptic Dysfunction in BCNU Model of Focal cortical dysplasia (FCD).

Kunal Singh won the 2^nd Prize at Poster Presentation in MSc category on 5^th Research Day, AIIMS New Delhi, the title of his study was “To investigate Cross-talk between Alpha7 Nicotinic Receptor and Glutamatergic activities in Neuropathic pain”.

Anjali Sharma got short talk travel grant by ISDN, 2025 in addition to that she also got selected for 21st San Servolo Advanced Epilepsy Course Bridging Basic with Clinical Epileptology, San Servolo (Venice, Italy) in August, 2025.