Name & Designation:    Dr. Deepak Pandey,   Scientist-II,

                                           Department of Reproductive Biology,

                     AIIMS, New Delhi.-29

 

Contacts:  Email: यह ईमेल पता spambots से संरक्षित किया जा रहा है. आप जावास्क्रिप्ट यह देखने के सक्षम होना चाहिए.  ,  यह ईमेल पता spambots से संरक्षित किया जा रहा है. आप जावास्क्रिप्ट यह देखने के सक्षम होना चाहिए.

                 Phone: +91 11 2659 3941

 

Qualifications:

• Ph.D. (Biotechnology), Himachal Pradesh University, Shimla, India (2011).
• M.Sc. (Biotechnology), Himachal Pradesh University (HPU), Shimla, India (2005).

 

Professional training and past positions:

• Worked as Scientist-B at Central Tasar Research & Training institute, Ranchi, Central Silk Board, Ministry of Textiles, Govt. of India (from November 5, 2015 to September 12, 2016).
• Worked as Research Associate on the project entitled “Function of caseinolytic proteases in Mycobacterium tuberculosis pathogenesis” at National Institute of Immunology, New Delhi India (from August 5, 2011 to September 30, 2014).

 

Research interests:

• Prostate pathologies (BPH & prostate cancer).
• Ovarian cancer.

 

Research Summary:

The research focus of our lab is on benign prostatic hyperplasia (BPH) and prostate cancer with special emphasis on the interaction between prostate stromal and epithelial cells. As men age, there is a typical alteration in the ratio of estradiol to dihydrotestosterone (DHT). Under the altered levels of these hormones, stromal cells secrete certain paracrine factors that cause proliferation of epithelial cells and lead to either BPH or prostate cancer. This altered stromal-epithelial interaction occurring in vivo is being studied in vitro by culturing the normal prostate stromal and epithelial cell lines. In addition to this, we are interested in identification, characterisation and validation of novel proteins and mi-RNAs as non-invasive biomarkers for prostate pathologies.

 

Group Members (Past & Present):

Ankit Roychoudhury, Abhishek Singh Yadav, Muninagesh Alapakam, Afsa Junaid  

 

Projects: ongoing, submitted and past:

• ICMR funded (42.3 Lakhs) project approved in March 2020. To elucidate the impact of micronutrients and vitamins on sex-steroid mediated stromal-epithelial interaction in prostate cells: role in maintenance of normal prostate physiology.
• ICMR funded (91 Lakhs) 2019-2022. Clinico-genetic prognostic signatures for development of metastatic Castration Resistant Prostate Cancer (as Co-Investigator). 
• AIIMS funded (10 Lakhs) 2017-2019. To study the effects of dietary flavonoids on prostate epithelial cells growing under the influence of prostate stromal cells.

 

Awards/Honours/Fellowships:

• Awarded Scholarship from Department of Biotechnology (DBT), Govt. of India for pursuing MSc Biotechnology, 2003
• Awarded Junior Research Fellowship (JRF), Indian Council of Medical Research (ICMR), 2006
• Awarded Senior Research Fellowship (SRF), Indian Council of Medical Research (ICMR), 2008
• Qualified ICMR-JRF (2005)
• Qualified GATE (Graduate Aptitude Test in Engineering) in life sciences with 97.40 percentile and All India Rank-275 (2006).
• Qualified DBT-JRF (2006)
• Qualified National Eligibility Test (NET- June, 2015) in life science with All India Rank-18

 

Selected Publications:

1. Pandey D*, Patel SKS, Singh R, Kumar P, Thakur V, Chand D* (2019). Solvent-tolerant acyltransferase from Bacillus sp. APB-6: Purification and Characterization. Indian J Microbiol; 59 (4): 500–507. (doi:  10.1007/s12088-019-00836-8: ^* Co-Corresponding author)
2. Choudhury AR, Gupta S, Chaturvedi PK, Kumar N, Pandey D* (2019). Mechanobiology of cancer stem cells and their niche. Cancer Microenviron; (doi: 10.1007/s12307-019-00222-4: ^*Corresponding author)
3. Choudhury AR, Kumar N, Sandeep K, Pandey D^* (2019). Stem cell repertoire in the prostate epithelium. J Stem Cell Res Ther; 5(2): 44-46. (doi: 10.15406/jsrt.2019.05.00133: ^*Corresponding author)
4. Singh PK, Yadav VK, Kalia M, Sharma D, Pandey D, Agarwal V (2019). Pseudomonas aeruginosa quorum-sensing molecule N-(3-oxo-dodecanoyl)-L-homoserine lactone triggers mitochondrial dysfunction and apoptosis in neutrophils through calcium signaling. Med Microbiol Immunol; 208(6): 855-868. (doi: 10.1007/s00430-019-00631-8)
5. Kumar P, Singh B, Thakur V, Thakur A, Thakur N, Pandey D, Chand D (2019). Hyper-production of taxol from Aspergillus fumigatus, an endophytic fungus isolated from Taxus sp. of the Northern Himalayan region. Biotechnol Rep; 15; 24: e00395. (doi: 10.1016/j.btre.2019.e00395)
6. Yadav D, Sandeep K, Pandey D. Monoclonal Antibodies. In: Sharma AK, Kesarwani RK, Dutt R (Eds). Nanotechnology and Targeted Drug Delivery System. First edition. Studera Press: Delhi; 2019: pp 321-337.
7. Singh R, Pandey D, Dhariwal S, Sood P, Chand D (2018). Bioconversion of acrylonitrile using nitrile hydratase activity of Bacillus sp. APB-6. 3 Biotech; 8(5): 225 (doi: 10.1007/s13205-018-1207-1)
8. Singh R, Pandey D, Devi N, Chand D (2018). Bench scale production of butyramide using free and immobilized cells of Bacillus sp. APB-6. Bioprocess Biosyst Eng; (doi:10.1007/s00449-018-1951-y)
9. Kumar N, Pandey D, Halder A (2018). Preventive, diagnostic and therapeutic applications of baculovirus expression vector system. In: Kumar D, Gong C (Eds). Trends in Insect Molecular Biology and Biotechnology. First edition. Austria: Springer: pp 163-191.
10. Choudhury AR, Kumar N, Sandeep K, Pandey D* (2017). Biotechnological Potential of Stem Cells. J Stem Cell Res Ther; 3(1): 212-219. (doi: 10.15406/jsrt.2017.03.00090: ^*Corresponding author)
11. Kumar P, Pandey D, Thakur V, Thakur A, Chand D (2017). Hyperproduction of tannin acylhydrolase in submerged fermentation from Aspergillus fumigatus. J Adv Microbiol; 3(2): 60-77 (ISSN Online: 2349-7785) 
12. 12. Yadav D, Sandeep K, Pandey D, Dutta RK (2017). Liposomes for Drug Delivery. J Biotechnol Biomater; 7: 276. (doi: 10.4172/2155- 952X.1000276) 
13. Pandey D, Singh R and Chand D (2011). An improved bioprocess for synthesis of acetohydroxamic acid using DTT (dithiothreitol) treated resting cells of Bacillus sp. APB-6. Bioresour Technol. 102, 6579–6586. (doi: 10.1016/j.biortech.2011.03.071)