Dr. Ajay Godwin Potnuri

Scientist -I

Department of Pharmacology

A.I.I.M.S, New Delhi-110029

डॉ. अजयगॉडविनपोटनुरी

वैज्ञानिक-I

भेषजगुणविज्ञानविभाग,

अ. भ. आ. सं., नईदिल्ली-110029

 

Contact Details: 4th Floor, Department of Pharmacology, Teaching Block, All India Institute of Medical Sciences (AIIMS), New Delhi 110029

Telephone: 011-26593677

Email ID:  यह ईमेल पता spambots से संरक्षित किया जा रहा है. आप जावास्क्रिप्ट यह देखने के सक्षम होना चाहिए.

Education:

• B.Pharmacy from Andhra University, Visakhapatnam
• M.S (Pharm) in Pharmacology and Toxicology from National Institute of Pharmaceutical Education and Research, Guwahati
• Ph.D in Biological Sciences from Sree Chitra Tirunal Institute for Medical Sciences and Technology, Thriuvananthapuram
• ICMR PDF from ICMR NARFBR, Turkapally, Shamirpet, Hyderabad

 

Research Interest/ area:

Cardiovascular Pharmacology and toxicology with a special emphasis on hypertensive heart disease and vascular biology

 

Past Position:

• Assistant Research Officer (Pharmacology) at National Ayurveda Research Institute for Panchakarma, Cheruthuruthy, Thrissur, Kerala (Jan’ 2021 – Sep’ 2022)

Ongoing Projects:

• Evaluation of Guduchi Sattva for its anti-platelet and thrombolytic potential using in-vitro and in-vivo experimental models, funded by Indian Council for Medical Research. [Budget:15,90,000]

Completed Projects:

• Acute and 90 days Toxicity profiling of AYUSH 64, funded by Central Council for Research in Ayurvedic Sciences. [Budget:18,97,450]
• Understanding the role of FFAR2 In Modulating atherosclerosis in WNIN/Ob rat, funded by Indian Council for Medical Research. [Budget:21,60,000]

Selected Publications:

1. Targeting histamine-2 receptor for prevention of cardiac remodeling in chronic pressure overload AG Potnuri, L Allakonda, A Appavoo, S Saheera, RR Nair Int J Card, 2016 202, 831833.

2. Histamine 2 receptor antagonism elicits protection against doxorubicin induced cardiotoxicity in rodent model, SK Kondru, AG Potnuri, L Allakonda, P Konduri, Molecular and Cellular Biochemistry, 1-12 , 2018

3. Syk–GTP RAC-1 mediated immune-stimulatory effect of Cuscuta epithymum, Ipomoea batata and Euphorbia hirta plant extracts VS Sudam, AG Potnuri, NJP Subhashini, Biomedicine & Pharmacotherapy 96, 742-749, 2018

4. Modulation of cardiac stem cell characteristics by metoprolol in hypertensive heart disease, S Saheera, AG Potnuri, RR Nair, Hypertension Research, Nature Publishing Group 2018 Feb 15. doi: 10.1038/s41440-018-0015-7.

5. Histamine-2 receptor antagonist Famotidine Modulates Cardiac Stem Cell characteristics in hypertensive heart disease, S Saheera, AG Potnuri, RR Nair, PeerJ. 2017 Oct 9;5:e3882. doi: 10.7717/peerj.3882. eCollection 2017.

6. Crocin attenuates cyclophosphamide induced testicular toxicity by preserving glutathione redox system, AG Potnuri, L Allakonda, M Lahkar, Biomedicine & Pharmacotherapy 2018 101, 174180

7. Association of histamine with hypertension induced cardiac remodelling and reduction of hypertrophy with Histamine 2-receptor antagonist famotidine in comparison with beta blocker metoprolol, AG Potnuri, L Allakonda, A Appavoo, S Saheera, RR Nair 2018. Hypertension Research, Nature Publishing Group

8. Protective effect of antioxidant Tempol on cardiac stem cells in chronic pressure overload hypertrophy, S Saheera, AG Potnuri, RR Nair, life sciences 2019, 222, 88-93

9. Involvement of Histamine 2 receptor in Alpha 1 adrenoceptor mediated cardiac hypertrophy and oxidative stress in H9c2 cardio myoblasts, AG Potnuri, L Allakonda, S Saheera, J Cardiovasc Transl Res. 2021 Feb;14(1):184-194.

10. Beta 1 adrenoceptor blockade promotes angiogenesis in hypertrophied myocardium of TAC Rat, L Allakonda, A. Kakaraparthi, AG Potnuri. Clinical and Experimental Pharmacology and Physiology 48 (1), 121-128.