Selected Publications and Patents:

1. Tripathi Manish, Santoshi Meghna, Yagya D Sharma and Sumit Rathore*. Majority of the erythrocyte binding proteins of the Pvfam "a" family of Plasmodium vivax interact with Basigin to assist parasite entry into the host cell. Front. Cell. Infect. Microbiol., 30 June 2025 Sec. Parasite and Host Volume 15 - 2025 | https://doi.org/10.3389/fcimb.2025.1592281.


2. Aptamer-Based Diagnosis for Plasmodium vivax Specific Malaria. Alam MS, Dhiman A, Bhardwaj T, Chatterjee S, Lakra V, Tripathi M, Lohani K, Sharma YD, Mirdha BR, Kumar A, Sharma TK, Rathore S*. ACS Infect Dis. 2025 Mar 14;11(3):762-772. doi: 10.1021/acsinfecdis.4c01047. Epub 2025 Mar 5.


3. Alam MS, Dhiman A, Bhardwaj T, Chatterjee S, Lakra V, Tripathi M, Lohani K, Sharma YD, Mirdha BR, Kumar A, Sharma TK, Rathore S*. Aptamer-Based Diagnosis for Plasmodium vivax Specific Malaria. ACS Infect Dis. 2025 Mar 14;11(3):762-772. doi: 10.1021/acsinfecdis.4c01047. Epub 2025 Mar 5


4. Unlocking the potential of blood-stage vaccines for malaria elimination. Nema S, Rathore S, Mohmmed A, Malhotra P.Trans R Soc Trop Med Hyg. 2025 Feb 8:traf013. doi: 10.1093/trstmh/traf013.


5. Identifying quantitative sncRNAs signature using global sequencing as a potential biomarker for tuberculosis diagnosis and their role in regulating host response. Kaul S, Nair V, Gcanga L, Lakshmanan V, Kalamuddin M, Anang V, Rathore S, Dhawan S, Alam T, Khanna V, Lohiya S, Ali S, Mannan S, Rade K, Parihar SP, Khanna A, Malhotra P, Brombacher F, Dasaradhi PV, Guler R, Mohmmed A.Int J Biol Macromol. 2024 Jun;271(Pt 2):132714. doi: 10.1016/j.ijbiomac.2024.132714. Epub 2024 May 28.


6. A dynamin-like protein in Plasmodium falciparum plays an essential role in parasite growth, mitochondrial development and homeostasis during asexual blood stages.Thakur V, Islam MM, Singh S, Rathore S, Muneer A, Dutta G, Banday MM, Arora P, Hossain ME, Jain S, Ali S, Mohmmed A. Biochim Biophys Acta Mol Cell Res. 2025 Mar 27:119940. doi: 10.1016/j.bbamcr.2025.119940. Online ahead of print.


7. The Microbiome and Metabolome of the Gut of Children with Sepsis and Septic Shock.Sankar J, Thakral V, Bharadwaj K, Agarwal S, Kabra SK, Lodha R, Rathore S*. J Intensive Care Med. 2023 Dec 10:8850666231216361. doi:10.1177/08850666231216361. PMID: 38073164 (*Corresponding author)


8. Plasmodium falciparum OPA3-like protein (PfOPA3) is essential for maintaining mitochondrial homeostasis and parasite proliferation. Narwal M, Jain S, Rathore S, Mohmmed A. FASEB J. 2023 Nov;37(11):e23235. doi: 10.1096/fj.202201386RR.


9. Kaul, V Nair, S Birla, S Dhawan, S Rathore, V Khanna, S Lohiya, S Ali, S Mannan, K Rade, P Malhotra, D Gupta, A Khanna, Mohmmed A. Latent Tuberculosis Infection Diagnosis among Household Contacts in a High Tuberculosis Burden Area: a companion Between Transcript Signature and Interferon Gamma Release Assay. Microbiology Spectrum, Marc/April 2022 Volume 10 Issue 2


10. Shaifali Jain, Mohd Asad, Reto Caldelari, Gaurav Datta, Shweta Singh, Sumit Rathore, Rebecca R. Stanway, Volker T. Heussler and Asif Mohmmed. Small-molecule inhibitors targeting prokaryotic ClpQ protease in Plasmodium display anti-malarial efficacies against blood and liver stages. bioRxiv preprint doi: https://doi.org/10.1101/2022.05.12.491652;


11. A Srivastava, P Nagar, S Rathore, N Adlakha, The Linker Region Promotes Activity and Binding Efficiency of Modular LPMO towards Polymeric Substrate. Microbiology spectrum 10 (1), e02697-21


12. Sapra L, Bhardwaj A, Azam Z, Madhry D, Verma B, Rathore S, Srivastava RK.Phytotherapy for treatment of cytokine storm in COVID-19. Front Biosci (Landmark Ed). 2021 Apr 30;26(5):51-75. doi: 10.52586/4924. PMID: 34027650.


13. Klionsky DJ, et al . Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition) .Autophagy. 2021 Jan;17(1):1-382. doi: 10.1080/15548627.2020.1797280. Epub 2021 Feb 8. PMID: 33634751; PMCID: PMC7996087.


14. Chourasia BK, Deshmukh A, Kaur I, Paul G, Panda A, Rathore S, Singh SK, Theisen M, Mohmmed A, Malhotra P. Plasmodium falciparum Clag9-Associated PfRhopH Complex Is Involved in Merozoite Binding to Human Erythrocytes. Infect Immun.2020 Jan 22;88(2):e00504-19. doi: 10.1128/IAI.00504 19. PMID: 31712270; PMCID:PMC6977125


15. Sharma S, Kumar G, Vashishta M, Pandey R, Rathore S, Chourasia BK, Singhal J,Deshmukh A, Kalamuddin M, Paul G, Panda A, Tatiya S, Rawat K, Gupta D, MohmmedA, Natarajan K, Malhotra P. Biochemical characterization of Plasmodium complement factors binding protein for its role in immune modulation. Biochem J.2018 Sep 14;475(17):2877-2891. doi: 10.1042/BCJ20180142. PMID: 30049893


16. Deshmukh A, Chourasia BK, Mehrotra S, Kana IH, Paul G, Panda A, Kaur I, Singh SK, Rathore S, Das A, Gupta P, Kalamuddin M, Gakhar SK, Mohmmed A, Theisen M, Malhotra P. Plasmodium falciparum MSP3 Exists in a Complex on the Merozoite Surface and Generates Antibody Response during Natural Infection. Infect Immun.2018 Jul 23;86(8):e00067-18. doi: 10.1128/IAI.00067-18. PMID: 29760216; PMCID:PMC6056863.


17. Mourão LC, Baptista RP, de Almeida ZB, Grynberg P, Pucci MM, Castro-Gomes T,Fontes CJF, Rathore S, Sharma YD, da Silva-Pereira RA, Bemquerer MP, Braga ÉM.Anti-band 3 and anti-spectrin antibodies are increased in Plasmodium vivax infection and are associated with anemia. Sci Rep. 2018 Jun 8;8(1):8762. doi:10.1038/s41598-018-27109-6. PMID: 29884876; PMCID: PMC5993813.


18. Mundra S, Thakur V, Bello AM, Rathore S, Asad M, Wei L, Yang J, Chakka SK, Mahesh R, Malhotra P, Mohmmed A, Kotra LP. A novel class of Plasmodial ClpP protease inhibitors as potential antimalarial agents. Bioorg Med Chem. 2017 Oct15;25(20):5662-5677. doi: 10.1016/j.bmc.2017.08.049. Epub 2017 Sep 5. PMID:28917450.


19. Datta G, Hossain ME, Asad M, Rathore S, Mohmmed A. Plasmodium falciparum OTU-like cysteine protease (PfOTU) is essential for apicoplast homeostasis and associates with noncanonical role of Atg8. Cell Microbiol. 2017 Sep;19(9). doi:10.1111/cmi.12748. Epub 2017 May 17. PMID: 28423214.


20. Paul G, Deshmukh A, Kaur I, Rathore S, Dabral S, Panda A, Singh SK, Mohmmed A, Theisen M, Malhotra P. A novel Pfs38 protein complex on the surface of Plasmodium falciparum blood-stage merozoites. Malar J. 2017 Feb 16;16(1):79.doi: 10.1186/s12936-017-1716-0. PMID: 28202027; PMCID: PMC5312596.


21. Rathore S, Dass S, Kandari D, Kaur I, Gupta M, Sharma YD. Basigin Interacts with Plasmodium vivax Tryptophan-rich Antigen PvTRAg38 as a Second Erythrocyte Receptor to Promote Parasite Growth. J Biol Chem. 2017 Jan 13;292(2):462-476. PMID: 27881677; PMCID:PMC5241724.


22. Alam MS, Zeeshan M, Rathore S, Sharma YD. Multiple Plasmodium vivax proteins of Pv-fam-a family interact with human erythrocyte receptor Band 3 and have a role in red cell invasion. Biochem Biophys Res Commun. 2016 Sep 23;478(3):1211-6. doi: 10.1016/j.bbrc.2016.08.096. Epub 2016 Aug 18. PMID:27545606.


23. Alam MS, Rathore S, Tyagi RK, Sharma YD. Host-parasite interaction: multiple sites in the Plasmodium vivax tryptophan-rich antigen PvTRAg38 interact with the erythrocyte receptor band 3. FEBS Lett. 2016 Jan;590(2):232-41. doi: 10.1002/1873-3468.12053. Epub 2016 Jan 23. PMID: 26823170; PMCID: PMC7163959.


24. Thakur V, Asad M, Jain S, Hossain ME, Gupta A, Kaur I, Rathore S, Ali S, Khan NJ, Mohmmed A. Eps15 homology domain containing protein of Plasmodium falciparum (PfEHD) associates with endocytosis and vesicular trafficking towards neutral lipid storage site. Biochim Biophys Acta. 2015 Nov;1853(11 Pt A):2856-69. doi: 10.1016/j.bbamcr.2015.08.007. Epub 2015 Aug 15. PMID: 26284889.


25. Singh AK, Rathore S, Tang Y, Goldfarb NE, Dunn BM, Rajendran V, Ghosh PC, Singh N, Latha N, Singh BK, Rawat M, Rathi B. Hydroxyethylamine Based Phthalimides as New Class of Plasmepsin Hits: Design, Synthesis and Antimalarial Evaluation. PLoS One. 2015 Oct 26;10(10):e0139347. doi: 10.1371/journal.pone.0139347. PMID: 26502278; PMCID: PMC4621027.


26. Alam MS, Choudhary V, Zeeshan M, Tyagi RK, Rathore S, Sharma YD. Interaction of Plasmodium vivax Tryptophan-rich Antigen PvTRAg38 with Band 3 on Human Erythrocyte Surface Facilitates Parasite Growth. J Biol Chem. 2015 Aug 14;290(33):20257-72. doi: 10.1074/jbc.M115.644906. Epub 2015 Jul 6. PMID:26149684; PMCID: PMC4536434.


27. Bhalla K, Chugh M, Mehrotra S, Rathore S, Tousif S, Prakash Dwivedi V, Prakash P, Kumar Samuchiwal S, Kumar S, Kumar Singh D, Ghanwat S, Kumar D, Das G, Mohmmed A, Malhotra P, Ranganathan A. Host ICAMs play a role in cell invasion by Mycobacterium tuberculosis and Plasmodium falciparum. Nat Commun. 2015 Jan 14;6:6049. doi: 10.1038/ncomms7049. PMID: 25586702.


28. Jain S, Rathore S, Asad M, Hossain ME, Sinha D, Datta G, Mohmmed A. The prokaryotic ClpQ protease plays a key role in growth and development of mitochondria in Plasmodium falciparum. Cell Microbiol. 2013 Oct;15(10):1660-73. doi: 10.1111/cmi.12142. Epub 2013 Apr 11. PMID: 23521916.


29. El Bakkouri M, Rathore S, Calmettes C, Wernimont AK, Liu K, Sinha D, Asad M, Jung P, Hui R, Mohmmed A, Houry WA. Structural insights into the inactive subunit of the apicoplast-localized caseinolytic protease complex of Plasmodium falciparum. J Biol Chem. 2013 Jan 11;288(2):1022-31. doi: 10.1074/jbc.M112.416560. Epub 2012 Nov 28. PMID: 23192353; PMCID: PMC3542988.


30. Rathore Sumit, Dutta Gaurav , Inderjeet kaur, Malhotra Pawan, Mohmmed Asif. "Disruption of cellular homeostasis triggers apoptosis-like programmed cell death pathways in malaria parasite." Cell Death and Disease. 2015 Jul 2;6(7):e1803. doi: 10.1038/cddis.2015.142.


31. Rathore S, Jain S, Sinha D, Gupta M, Asad M, Srivastava A, Narayanan MS, Ramasamy G, Chauhan VS, Gupta D, Mohmmed A. Disruption of a mitochondrial protease machinery in Plasmodium falciparum is an intrinsic signal for parasite cell death. Cell Death Dis. 2011 Nov 24;2(11):e231. doi: 10.1038/cddis.2011.118. PMID: 22113196


32. Rathore S, Sinha D, Asad M, Böttcher T, Afrin F, Chauhan VS, Gupta D, Sieber SA, Mohmmed A. A cyanobacterial serine protease of Plasmodium falciparum is targeted to the apicoplast and plays an important role in its growth and development. Mol Microbiol. 2010 Aug;77(4):873-90. doi:10.1111/j.1365-2958.2010.07251.x. Epub 2010 Jun 10. PMID: 20545854.

   Patent:

Rathore S, , Sinha D, Asad M and Mohmmed A "Use of small peptides to inhibit the growth of Plasmodium falciparum (erythocytic stage)" Registration Number- 2057/DEL/2008