Dr. Uddipan Das

Dr. Uddipan Das

Photograph

Current Designation & Contact Details

Scientist-I

Department of Biophysics, Near Lecture Theater-2, PC Block, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029

Phone (office): +91-11-26594259, Ext: 4259

Email: This email address is being protected from spambots. You need JavaScript enabled to view it.

Recent Employment Details (Past few years)

1. 2016 - present: Scientist-I (Department of Biophysics, All India Institute of Medical Sciences, New Delhi)

2. 2014-2016: Senior Resident/Demonstrator (Department of Biophysics, All India Institute of Medical Sciences, New Delhi)

Brief Research Area

Structural biology: We are interested in understanding the intricate structure and function of Membrane proteins and Macromolecular complexes. To accomplish this, we are harnessing the power of Cryo-Electron microscopy and X-ray crystallography along with other biophysical and biochemical methods in order to understand the structure function relationships.

Awards & Honours

1. Visiting scientist at the University of Stanford, Cryo-EM center, California 2022-2023.

2. SERB international research experience award (Government of India) 2022.

3. Visiting scholar at European Molecular biology Laboratory, Hamburg, Germany, 2013.

4. European Molecular Biology Organization (EMBO) Fellowship 2013.

5. Indian Council of Medical Research Junior research fellowship 2009.

6. Department of Biotechnology Junior research fellowship 2009.

7. Graduate Aptitude Rest in Engineering (Life Sciences), 2009

8. Centre of Scientific and Industrial Research NET 2009.

Selected Publications/Patents (Last 5 years)

Google Scholar Link: https://scholar.google.com/citations?user=_YQkkBcAAAAJ&hl=en

1. Singh M, Haque MA, Tikhomirov A, Shchekotikhin, A, Das U, Kaur, P (2022). Computational and biophysical characterization of heterocyclic derivatives of anthraquinone against Human Aurora Kinase A. ACS Omega (accepted)

2. Sharma P, Kumar M, Tripathi MK, Gupta D, Vishwakarma P, Das U & Kaur P (2022) Genomic and structural mechanistic insight to reveal the differential infectivity of omicron and other variants of concern. Comput Biol Med 150, 106129.

3. Sharma D, Singh M, Kaur P & Das U* (2022) Structural analysis of LpqY, a substrate-binding protein from the SugABC transporter of Mycobacterium tuberculosis , provides insights into its trehalose specificity. Acta Crystallogr Sect D Struct Biol 78, 835–845.

4. Gupta D, Kumar M, Singh M, Salman M, Das U & Kaur P (2022) Identification of polypharmacological anticancerous molecules against Aurora kinase family of proteins. J Cell Biochem 123, 719–735.

5. Singh M, Malhotra L, Haque MA, Kumar M, Tikhomirov A, Litvinova V, Korolev AM, Ethayathulla AS, Das U, Shchekotikhin AE & Kaur P (2021) Heteroarene-fused anthraquinone derivatives as potential modulators for human aurora kinase B. Biochimie 182, 152–165.

6. Sabharwal N, Varshney K, Rath PP, Gourinath S & Das U* (2020) Biochemical and biophysical characterization of nucleotide binding domain of Trehalose transporter from Mycobacterium tuberculosis. Int J Biol Macromol 152, 109–116.

7. Das U*, Singh E, Dharavath S, Tiruttani Subhramanyam UK, Pal RK, Vijayan R, Menon S, Kumar S, Gourinath S & Srinivasan A (2019) Structural insights into the substrate binding mechanism of novel ArgA from Mycobacterium tuberculosis. Int J Biol Macromol 125, 970–978.

8. Gupta AK, Pokhriyal R, Das U, Khan MI, Kumar DR, Gupta R, Chadda RK, Ramachandran R, Goyal V, Tripathi M & Hariprasad G (2019) Evaluation of α-synuclein and apolipoprotein e as potential biomarkers in cerebrospinal fluid to monitor pharmacotherapeutic efficacy in dopamine dictated disease states of parkinson’s diseaseand schizophrenia. Neuropsychiatr Dis Treat 15, 2073–2085.

9. Das U, Pogenberg V, Subhramanyam UKT, Wilmanns M, Gourinath S & Srinivasan A (2014) Crystal structure of the VapBc-15 complex from mycobacterium tuberculosis reveals a two-metal ion dependent pin-domain ribonuclease and a variable mode of toxin-antitoxin assembly. J Struct Biol 188, 249–258.

10. Das U, Kumar N, Gourinath S & Srinivasan A (2013) Preliminary crystallographic analysis of recombinant VapBC-15 toxin-antitoxin complex from Mycobacterium tuberculosis. Acta Crystallogr Sect F Struct Biol Cryst Commun 69, 1242–1245.