Introduction

Prof.Dipendra K Mitra

2018-03-28T17:04:35+05:30

Prof.Dipendra K Mitra

Professor & Head of the Department

Department of Transplant Immunology and Immunogenetics

All India Institute of Medical Sciences

Ansari Nagar, New Delhi-110029

Telephone: +91 11 2659 4638

+91 11 2659 4446

Fax: +91 11 26588641, 26588663

E-mail: hodtii@gmail.com; salilmitra2@gmail.com

VISION

“The subject of Immunology has grown globally and in the country over the years. There are very few institutions in the country where Immunology is taught and these curriculum lack immune related applications targeted at patient care. AIIMS being most excellent tertiary patient care service with high patient load, suitable infrastructure cum expertise. Our department has been crucial in promoting clinical research in multiple areas of immunology. For the last more than four decades of existence, the department has been continuously providing patient care services including HLA typing and donor selection both for HSCT and organ transplantation, identification of donor specific antibodies by cross matches/PRA,diagnosis of HLA associated disease, Flowcytometry and other related clinical investigations.Several research activities were initiated and developed. These include role of HLA in disease susceptibility and progression, immunogenetics of autoimmune (RA, T1D, SLE, Celiac disease) and infectious diseases (Leprosy, Tuberculosis, Leishmaniasis, HIV/AIDS); Genomic diversity of HLA, HLA matching and transplant outcome, antibody basis of rejection, effector immune functions, immune response genes, technology development etc.,In the past 2 decades, the patient care services and research has expanded tremendously. The clinicians always being under extensive pressure of patient loads often demand more recent investigations like chimerism analysis for hematopoietic stem cell monitoring, donor specific antibody identification for renal transplantation, immunophenotyping for leukemia, diagnostics of primary immunodeficiency (PID) disorders (LAD1, LAD2, SCID,CVID,CGD etc., The department has already accomplished such additional investigations and perceives to further expand and utilize the expertise established for the benefit of clinical services on routine basis. Newer technologies now available in the department include Luminex based anti-donor antibody identification, Sequence based HLA typing and Flowcytometry based immunophenotyping. The department established an unrelated donor marrow donor registry (AIDMR) in 1994 for patients requiring stem cell transplantation but have no HLA matched family donor. We maintain the links with international donor pool as well. The department has been making extensive efforts in increasing donor recruitment drive using limited resources. Research areas of the department have been further expanded in the past few years. We have initiated studies on immunogenetics of HIV, role of non-classical HLA in organ and bone marrow transplantation and in TB, studies on the phenotypic and functional characterization of T cell subsets in shaping host immune response, pathways of immune suppression in diseases like TB, HIV, leprosy and visceral leishmaniasis. Our efforts are focused on improving patient services, on increasing capacity building as well as human resource development and we intend to continue with such objectives in future.The department intends to develop and boost national and international networking both in research and academia relating to molecular research in indigenous natural products such as plant derived medicinal ingredients as immunomodulator, potential immunotherapeutic agents.The department has been advised by the SFC sub-committee to initiate integrated MD+Ph.D and M.Sc+Ph.D curriculum in Medical and Experimental Immunology. In the long term the department intends to expand to a Centre for Immunology and Molecular Medicine ”

MILESTONES ACHIEVED

The department continued its activities in teaching, research and hospital services related to a range of laboratory investigations for patients requiring organ and hematopoietic stem cell transplantation (HSCT) as well as those needing HLA test for disease diagnostic purposes. Several sensitive assays such as the Luminex based HLA testing and antibody screening system have been well established and are in routine use. The solid phase assays provide crucial information on donor specific antibodies (DSA) and virtual cross match for patients referred to the Department from AIIMS and other centres in India. To that extent, the AIIMS laboratory continue to serve as the ‘national referral centre’ for HLA testing SPA based DSA determination and post transplant antibody monitoring. Further, a national level Quality Control and Quality Assurance (QC/QA) service is offered to nearly 15 centres engaged in HLA testing all over India. Services are also offered for the detection of non-HLA antibodies, particularly those directed to MHC class I related Antigen (MICA) system on case to case basis. Similarly SNP based genetic polymorphism analysis in cytokines and chemokine genes as well as Chimerism analysis for HSCT patients is offered on routine basis. The Department has been designated as ‘Centre of Excellence in Molecular Medicine’ by the Indian Council of Medical Research.

The research activities of the department span several key areas of translational value. These include i) Immunobiology of renal transplantation with specific focus on determining the clinical relevance of HLA and non-HLA specific antibodies, ii) Genetic architecture of autoimmune diseases with particular focus on type 1 diabetes and celiac disease and evaluation of HLA linked biomarkers, iii) Immunogenetic basis of susceptibility to HIV infections and disease progression to AIDS, iv) Immune predictors of early graft rejection, both in HSCT as well as organ transplantation. The focus here is to evaluate the relevance of MICA antibodies as well as soluble MICA levels as predictors of graft outcome , v) Immunological mechanisms underlying infectious diseases with particular focus on Leishmaniasis and tuberculosis, vi) Immunophenotyping of patients with various types of leukemia and evaluation of novel immunological tools, vii) Clinical significance of HLA-G molecule in hematopoietic stem cell transplantation, viii) HSCT monitoring and follow up using in-house STR kits for Chimerism analysis, ix) Expansion of the Asian Indian Donor Marrow Registry, x) Immunogenetic basis of nasopharyngeal carcinoma.

Professor Mitra and his group have published several original research papers in leading international journals. Currently 5 students are pursuing for Ph.D under his leadership. 4 of his students who have already been awarded Ph.D under him, occupy positions of eminence in India and abroad.

Areas of Interest:

Understanding the role of various lymphocyte subsets, particularly at local pathological sites in disease pathogenesis.

Focussing on local immune response among patients with chronic intracellular infections (tuberculosis, leishmaniasis, leprosy, HIV-Tb), rheumatoid arthritis and transplant patients.

Offering diagnostic services for patients with Leukemia and Primary Immune Disorders.

Focussing on improving patient care services, on increasing capacity building as well as human resource development

Boosting national and international networking both in research and academia relating to molecular research in indigenous natural products such as plant derived medicinal ingredients as immunomodulators and potential immunotherapeutic agents.

Initiating integrated MD+Ph.D and M.Sc+Ph.D curriculum in Medical and Experimental Immunology.

Expanding the Department to a Centre for Immunology and Molecular Medicine.

Significant Events:

Appointed as Head of the Department, Dept of TII, AIIMS in Dec, 2014.

Research

A) Funded projects:

Projects-Completed:

(1) Role of FoxP3+ regulatory T cells in polarized immunity in leprosy patients. Funding agency: ICMR, duration 2010 -2013, Total Sanction: Rs. 75.20 Lacs (Project Investigator: Prof. D.K.Mitra)

(2) CD 26 Mediated Chemokine Activation: Role in suppression of immunity among visceral Leishmaniasis patients. Funding agency: DBT, duration 2010 -2013, Total Sanction: Rs. 92.78 Lacs (Project Investigator: Prof. D.K.Mitra)

(3) Impact of FoxP3+ Treg cells on the host immune response among HIV-TB co-infected patients: relevance in multidrug resistance tuberculosis (MDR-TB). Funding agency: ICMR, duration 2011 -2013, Total Sanction: Rs. 49.40 Lacs (Project Investigator: Prof. D.K.Mitra)

Projects-Ongoing:

(1) Representation, trafficking and functional interaction of effector and regulatory T cells: Impact on the local immune response in rheumatoid arthritis. Funding agency: DST, duration 2012 -2015, Total Sanction: Rs. 49.98 Lacs (Project Investigator: Prof. D.K.Mitra)

(2) Impact of transcriptional gene silencing of HIV1C on ecto-enzymes and negative co-stimulatory molecules expressed by T cell subsets: relevance to chronic immune activation in HIV infection Funding agency: DBT, duration 2013-2016, Total Sanction: Rs. 75.24 Lacs (Project Investigator: Prof. D.K.Mitra)

(3) Cytokine profile of poly functional T cells in Latent and Active Tuberculosis patients: Impact of regulatory T cells. Funding agency: ICMR, duration 2014 -2017, Total Sanction: Rs. 97.58 Lacs (Project Investigator: Prof. D.K.Mitra)

(B) Collaborative Projects:

Role of FoxP3+ regulatory T cells in polarized immunity in leprosy patients. Funding Agency - Indian Council of Medical Research (ICMR), Collaboration with Department of Dermatology & Venereal diseases, AIIMS & Central JALMA Institute for Leprosy & other Mycobacterial Diseases, Taj Ganj, Agra
CD26 mediated chemokine activation: role in suppression of immunity among visceral Leishmaniasis patients. Funding Agency - Department of Biotechnology, Government of India, collaboration with Balaji Utthan Sansthan Fraser Road, Patna-Bihar
Impact of FoxP3+ Treg cells on the host immune response among HIV-TB co-infected patients: relevance in multidrug resistance tuberculosis (MDR-TB). Funding Agency - Indian Council of Medical Research (ICMR), collaboration with Dr. B C Roy Post-graduate Institute of Basic Medical Sciences (IPGME&R), 244B, AJC Bose Road, Kolkata
Impact of Regulatory T cells on host Immunity among older pulmonary tuberculosis patients. Funding Agency: Indian Council of Medical Research (ICMR), collaboration with Department of Medicine, AIIMS
Representation, trafficking and functional interaction of effector and regulatory T cells: Impact on the local immune response in rheumatoid arthritis. Funding Agency: Indian Council of Medical Research (ICMR), collaboration with Department of Medicine, AIIMS
Impact of transcriptional gene silencing of HIV1C on ecto-enzymes and negative co-stimulatory molecules expressed by T cell subsets: relevance to chronic immune activation in HIV infection Funding Agency: Department of Biotechnology, Government of India, collaboration with Department of Microbiology, Assam Medical College, Dibrugarh and Christian Institute of Health Sciences & Research, Dimapur
Cytokine profile of poly functional T cells in Latent and Active Tuberculosis patients: Impact of regulatory T cells. Funding Agency: Department of Biotechnology, Government of India, collaboration with Department of Microbiology, Assam Medical College, Dibrugarh

EDUCATION (Academic Activities)

Ph.D Students:

(a) Awarded:

1) Amar Singh, Ph.D Title: “Immunoregulatory Role of Co-stimulatory Molecules in

Tuberculosis”(2012)

2) Ankit Saxena, PhD Title: “Studies on the role of Chemokines on T-cell mediated

allo-reactivity in Renal Transplantation”(2012)

3) Ambak K Rai, Ph.D Title: “Studies on T-cell Mediated suppression of immunity

in Visceral Leishmaniasis patients”(2010)

4) Prabhat K, Ph.D Title: “Immunology of Regulatory T-cell subsets in Human

Tuberculosis”(2009)

(b) Currently working :

i) Polarized Immunity in Human Leprosy: Role of effector and Regulatory T cell subsets in shaping host immune response (Student: Soumi Sadhu)

ii) Study of T cell responses among older patients with TB (Student: Manju Namdeo)

iii) Studies on Immunoregulatory mechanisms for host T cell response in human tuberculosis (Student: Divya Kamboj)

iv) Studies of distinct T cell subsets in the pathogenesis of rheumatoid arthritis (Student: Kaustav Chowdhury)

v) Phenotypic and functional characterization of various T cell subsets in Sarcoidosis (Student: Rinkee Kumari)

Modules for laboratory training in Immunology and Immunogenetics:

Short term training: During the year, 18 young scientists and clinicians from various universities and institutions in India received short term training for laboratory techniques in HLA testing, antibody determination, flow cytometry, Chimerism analysis and other immunological investigations.

Training to MD/DM students: The Department continued to offer short term exposure in laboratory tools and technologies and their clinical significance to MD/MSstudents various departments of the institute. These include students from Pathology (8), Medical Oncology (2), Laboratory Medicine (7), and Hematology (3). Similarly, 4 doctors from the Department of Nephrology, Maulana Azad Medical College, Delhi undertook trainingand learnt techniques in HLA testing and other immunological investigations. The Department continued to provide training to under graduate and post graduates students, both from within the institute and to those coming from other universities and research centres.

Visiting scientists:

Dr.Samarjit Das, Ph.D, Assistant Professor, Department of Pathology, John Hopkins University, Baltimore, Maryland-21218, USA (30^th May, 2014 and 10^th Feb, 2015).

Publicatiions:

Amar Singh, Aparajita Ballave Dey, Anant Mohan and Dipendra K Mitra. Programmed death-1 receptor suppresses g-IFN producing NKT cells in human tuberculosis. Tuberculosis 94 (2014) 197-206

Amar Singh, Anant Mohan, Aparajita Ballave Dey and Dipendra K Mitra.Inhibiting PD-1 pathway rescues M. tuberculosis specific IFN-γ producing T cells from apoptosis among pulmonary tuberculosis patients. Journal of Infectious Disease. 2013;208:603–15 doi: 10.1093/infdis/jit206 (Impact Factor:6.410 )

Amar Singh, Aparajita Ballave Dey, Prabhat Kumar Sharma, Anant Mohan, and Dipendra K Mitra. Foxp3⁺ regulatory T cells among tuberculosis patients: Impact on prognosis and restoration of antigen specific IFN-g producing T cells. PLoS ONE 2012;7(9):e44728. (Impact Factor: 4.41)

Amar Singh, Aparajita Ballave Dey, Anant Mohan and Dipendra K Mitra..Programmed death-1 receptor suppresses g-IFN producing NKT cells in human tuberculosis. Tuberculosis 94(2014) 197-206.

R. Ghosh, A. Sharma, Dipendra K. Mitra, S. K. Agarwal, A. K. Dinda, and Ankit Saxena. Study of CC chemokine receptor 5 in renal allograft rejection. Indian J Nephrol. 2013 May-Jun; 23(3): 196–200. doi: 10.4103/0971-4065.111848 (Impact Factor:0.867)

Saha PK, Sharma PK, Sharma SK, Singh A, Mitra DK. Recruitment of Th1 effector cells in human tuberculosis: hierarchy of chemokine receptor(s) and their ligands. Cytokine, 2013 Jul; 63(1):43-51. doi: 10.1016/j.cyto.2013.04.001. Epub 2013 May 1. (Impact factor 3.1).

Sinha M, Singh A, Shokeen A, Sharma P, Kaushik S, Mitra DK, Kaur P, Sharma S, Singh TP. Evidence of a novel allergenic protein narcin in the bulbs of Narcissus tazetta. Int J Biochem Mol Biol. 2013 Jul 29; 4(2):95-101. Print 2013.PMID: 23936740 (Impact Factor: 1.318)

Sharma P, Yamini S, Dube D, Singh A, Mal G, Pandey N, Sinha M, Singh AK, Dey S, Kaur P, Mitra DK, Sharma S, Singh TP. Structural basis of the binding of fatty acids to peptidoglycan recognition protein, PGRP-S through second binding site. Arch Biochem Biophys.2013 Jan 1;529(1):1-10. (Impact Factor: 2.935)

Ambak K. Rai, Chandreshwar P. Thakur and Dipendra K. Mitra,. Impaired Expression of CD26 Compromises T cell Recruitment in Human Visceral. European Journal of Immunology. 2012 42(10): 2782-91.(Impact Factor: 5.13)

Sharma P, Yamini S, Dey S, Mitra DK, Kaur P, Sharma S, Singh TP. Structural studies on molecular interactions between camel peptidoglycan recognition protein, CPGRP-S, and peptidoglycan moieties N-acetylglucosamine and N-acetylmuramic acid. J Biol Chem. 2012 Jun 22;287(26):22153-64. doi: 10.1074/jbc.M111.321307. Epub 2012 May 9. (Impact factor 5.117)

Rao A, Gupta S, Dinda AK, Sharma A, Sharma VK, Kumar G, Mitra DK, Prashant CK, Singh G. Study of clinical, biochemical and immunological factors determining stability of disease in patients with generalized vitiligo undergoing melanocyte transplantation.. Br J Dermatol. 2012 Jun;166(6):1230-6. doi: 10.1111/j.1365-2133.2012.10886.x. (Impact factor 3.944)

Ambak K. Rai, Chandreshwar P. Thakur, Amar Singh, Tulika Seth, Sandeep K. Srivastava, Pushpendra Singh, Dipendra K. Mitra. Regulatory T cells Suppress T cell Activation at the Pathologic Site of Human Visceral Leishmaniasis. PLoS ONE 2012; 7(2):e31551 (Impact factor: 4.41)

A. K. Rai, C. P. Thakur, T. Seth, D K Mitra.Enrichment of invariant natural killer T cells in the bone marrow of visceral leishmaniasis patients. Parasite Immunol. 2011 Dec; 33(12):688-91. (Impact factor: 2.79)

Pradeep Sharma, Divya Dube, Amar Singh, Biswajit Mishra, Nagendra Singh,Mau Sinha, Sharmistha Dey, Punit Kaur, Dipendra K. Mitra, Sujata Sharma and Tej P. Singh. Structural basis of recognition of pathogen-associated molecular patterns and inhibition of pro-inflammatory cytokines by camel peptidoglycan recognition protein. JBC, 2011 May 6:286(18): 16208-16217.( Impact factor:4.8)

Ambak K. Rai, Chandreshwar P. Thakur, T. Velpandian, Surendra K. Sharma, Balram Ghosh, Dipendra K. Mitra. High Concentration of Adenosine in Human Visceral Leishmaniasis: Despite Increased ADA and Decreased CD73. Parasite Immunol. 2011 Nov; 33(11):632-6. (Impact factor: 2.795)

A. K. Rai, C. P. Thakur, T. Seth, D K Mitra.Early activated Th-1 type and dominantly non-invariant natural killer T (CD3⁺CD161⁺Va24^-) cells in bone marrow among visceral leishmaniasis patients. Int. J. Parasitology. 2011 Aug 15;41(10):1069-77 (Impact factor: 3.637)

Saxena A, Rai A, Raina V, Seth T, Mitra DK. Expression of CD13/aminopeptidase N in precursor B-cell leukemia: role in growth regulation of B cells. Cancer Immunol Immunother. 2010 Jan; 59(1):125-35. (Impact factor: 3.637)

Sharma PK, Saha PK, Singh A, Sharma SK, Ghosh B, Mitra DK. FoxP3+ regulatory T cells suppress effector T-cell function at pathologic site in miliary tuberculosis. Am J Respir Crit Care Med. 2009 Jun 1; 179(11):1061-70. (Impact factor: 11.08)

Sharma SK, Mohan A, Sharma A, Mitra DK. Miliary tuberculosis: new insights into an old disease. Lancet Infect Dis. 2005 Jul; 5(7):415-30. (Impact factor: 19.966)

Mitra DK, Sharma SK, Dinda AK, Bindra MS, Madan B, Ghosh B. Polarized helper T cells in tubercular pleural effusion: phenotypic identity and selective recruitment. Eur J Immunol. 2005 Aug; 35(8):2367-75. (Impact factor: 5.635)

Mitra DK, Singh HP, Singh M, Alwadi A, Kochupillai V, Raina V, Kumar L, Mehra NK. Reconstitution of naïve T cells and type 1 function after autologous peripheral stem cell transplantation: impact on the relapse of original cancer. Transplantation. 2002 Apr 27;73(8):1336-9. (Impact factor: 3.498)

De Rosa SC, Mitra DK, Watanabe N, Herzenberg LA, Herzenberg LA, Roederer M. Vdelta1 and Vdelta2 gammadelta T cells express distinct surface markers and might be developmentally distinct lineages. J Leukoc Biol. 2001 Oct;70(4):518-26. (Impact factor: 4.60)

Venuprasad K, Parab P, Prasad DV, Sharma S, Banerjee PR, Deshpande M, Mitra DK, Pal S, Bhadra R, Mitra D, Saha B. Immunobiology of CD28 expression on human neutrophils. I. CD28 regulates neutrophil migration by modulating CXCR-1 expression. Eur J Immunol. 2001 May;31(5):1536-43. (Impact factor: 5.635)

Roederer M, Raju PA, Mitra DK, Herzenberg LA, Herzenberg LA. HIV does not replicate in naive CD4 T cells stimulated with CD3/CD28. J Clin Invest. 1997 Apr 1; 99(7):1555-64. (Impact factor: 15.387)

Mitra DK, Mehra NK, Maiti TK, Banerjee A, Taneja V, Rajalingam R, Ahuja RK, Bhattacharya BC. CD4+ T-cell responses to recombinant hsp65 and hsp18 of M. leprae and their trypsin-digested fragments in leprosy: diversity in HLA-DR restriction. Int J Lepr Other Mycobact Dis. 1995 Dec; 63(4):518-28. (Impact factor: 6.07)

Patient care: (2013-’14)

Facilities available in the Department: i) HLA matching, ii) Antibody determination, iii) Virtual cross match assays, iv) Flow Cytometry, v) Tissue Culture, vi) ELISA, vii) Chimerism assays, viii) Sequencing, ix) RT-PCR, x) SNP analysis

Free of cost service provided for Leukemia phenotyping and phenotyping for Primary Immunodeficiency diseases

TRANSPLANTATION(2013-’14)

HLA matching

Recipients Donors Total

Renal Transplantation 309 252 561

Hematopoietic Stem Cell Transplantation

Aplastic anemia 120 331 451

Acute Myeloid Leukemia 104 214 318

Acute Lymphocytic Leukemia 50 139 189

Chronic Myeloid Leukemia 7 14 21

Thalassemia 42 98 140

Others 47 110 157

Total 370 986 1356

Cadaver Donor Organ Transplantation

Cadaver Donor 10 10 20

Cross Match test

- Serology 515

- Flowcytometry 132

Panel reactive Antibody Screening

Luminex PRA (screening) 183

Luminex PRA (class I and II) 225

DIAGNOSTICS

Spondyloarthropathies – HLA-B27 screening 481

Other diseases (Behcets’ Disease/Narcolepsy/Celiac Disease) 75

Chimerism testing 160

Leukocyte Adhesion deficiency/ Chronic Granulomatous disease 230

NK/Treg/T/B/Monocyte frequency 275

Unrelated Donor search for BMT 206

During the year, a total of 206 requests for search of unrelated HLA matched donors from the `Asian Indian Donor Marrow Registry’ for bone marrow transplantation (BMT) were received. These include 81 from USA, 49 from Europe, 54 from various Asian countries and 22 from India.

Dr. Uma Kanga

2018-03-28T16:49:33+05:30

Name : Dr. Uma Kanga

Designation : Assistant Professor

Male / Female : Female

Address : Dept of Transplant Immunology and Immunogenetics

All India Institute Of Medical Sciences

Ansari Nagar, New Delhi-110029

Date of birth : 24^thApril, 1964

E-mail address : umakanga@hotmail.com

Phone No. : 011-26594463, 9810862276

Educational Qualifications : PhD

Degrees obtained (Begin with Bachelor's Degree)

______________________________________________________________________________________

Degree Institution Field/Subject(s) Year

______________________________________________________________________________________

1. BSc (Hons) Punjab University Biochemistry 1984

2. MSc (Hons) Punjab University Biochemistry 1986

3. PhD AIIMS Immunogenetics 1996

Research /Training Experience:

Duration	Designation	Institution	Nature of Work
March 2010 – till date	Scientist-II (Grade 4)	AIIMS	Research – Immunogenetics, Histocompatibility and Translant Monitoring Supervision of Patient care Services for Transplant Program of AIIMS Technology Development Quality assurance
March 2005-2010	Scientist-II (Grade 3)	AIIMS	Research – Immunogenetics, Histocompatibility and Translant Monitoring Supervision of Patient care Services for Transplant Program of AIIMS Technology Development Quality assurance
March 1997-2005	Scientist-II (Grade 2)	AIIMS	Research – Immunogenetics, Histocompatibility and Translant Monitoring Patient care Services for Transplant Program of AIIMS
June 1995-1997	Scientist-I	AIIMS	Research – Immunogenetics, Histocompatibility and Translant Monitoring Patient care Services for Transplant Program of AIIMS

Research Specialization Achieved

Research Experience

I have been working in the area of Histocompatibility, Immunogenetics and transplant Immunologysince past 18 years. My job involves supervision of the tissue typing laboratory, which is the national referral center for HLA testing of patients requiring Organs and Bone marrow transplants. My research interests are focused on investigating the genetic diversity of HLA genes in Indian population, understanding association of HLA genes with diseases like type 1 diabetes, autoimmune thyroiditis, spondilitis, epilepsy, vitiligo, etc and investigation genetic and immunological factors influencing outcome of transplants. I have made significant contribution towards development and expansion of the Asian Indian Bone Marrow registry (AIDMR), which is the first and only Indian volunteer donor registry.

Teaching Experience : I have been teaching the undergraduate and post graduate students from AIIMS and those sent from other Indian centres for training. Under my supervision various thesis have been done

Chief Supervisor- 3 ongoing Co-Supervisor 3 (ongoing), 5 (completed)

DM/MD thesis- 3 (completed)

Awards & Fellowships

Nov2014-Jan 2015 : Japanese Science and Promotion Society (JSPS) Selected and invited by as invited fellow to Tokai University, Japan (US$ 7900)

Oct 2008- March 2009 : Commonwealth Academic Staff Fellowship, London UK- Selected and nominated by Govt of India. Worked at the Anthony Nolan Research Institute, Royal Free Hospital, London Funded by Commonwealth Scholarship Commission, UK and British Council, UK (support 12,500 GBP).

2007 & 2004 : Selected from the Asia Pacific network for participation in Bioinformatics Course-`Genome Informatics for Type 1 Diabetes Disease gene Mapping' held at Bethesda,USA and at Melbourne, Australia. I was given full financial support for participation (US$3000, AUS$ 2500).

2000 : Selected and invited by Ministry of Education, Science, Sports and Culture, Japan and provided Grant-in-Aid for Scientific Research on Priority area named Medical Genome Science. Visitor ship at the Dept of Molecular Life Sciences, Tokai University, Japan (US$ 8,000).

2000 : Selected for FIMSA bursary award for participation in the 2^nd Congress of the Federation of Immunological Societies of Asia Oceania held at Bangkok, Thailand.

1996 : Selected by the Federation of Immunological Societies of Asia Oceania (FIMSA) and Indian Immunology Society for participation in ASI/FIMSA/AMRAD `Advanced Course in Immunology' at Canberra, Australia , awarded travel bursary (US$ 1250).

Trainings (National and International)

22/11/14- 02/01/15 : Next Generation Sequencing for HLA diversity study, Tokai University, Japan

05/10/08-31/03/09 : Hematopoietic stem cell transplantation at ANRI, Royal Free Hospital, London, UK

26/02/07 – 03/03/07 : Bioinformatics course – Type 1 Diabetes disease gene mapping- Melbourne, Australia.

28^th Nov. 2005 : HLA Technology transfer workshop, T1DGC, Royal Melbourne Hospital, Melbourne, Austrailia

10/10/05 – 27/10/05 : Immunogenetic and humaoral aspects of Type 1 diabetes, St Vincent Hospital, Paris.

05/12/04 – 24/12/04 : Polymorphism of non-MHC markers (ICAM1 and CTLA4) in the Type 1 Diabetes at the Dept. of Immunoogy, St. Vincent Hospital, Paris.

04/04/04 – 08/04/04 : Genome Informatics for Type 1 Diabetes Disease gene Mapping – Training course in Bioinformatics, Bethesda Maryland, USA.

01/08/03 – 10/09/03 : Autoantibodies (anti GAD and IA-2) analysis in Type 1 diabetes and high resolution HLA testing, Dept. of Immunology, Hopital Necker, Paris, France with Dr. Sophie C Zucmann.

05/03/00 – 09/03/00 : FIMSA-IIS Advanced course in Basic and Molecular Immnology, New Delhi, India.

15/11/00 – 14/12/00 : Training in Sequence Based Typing (SBT) of HLA genes, microsatellite analysis using automated DNA sequencer, Tokai University, Japan with Prof H Inoko.

07/11/98 : International workshop on Flow Cytometry at AIIMS, New Delhi, India.

01/12/97 – 04/12/97 : The FACS Calibur key operator training held at Becton Dickinson Immunocytometry Systems, Singapore.

22/09/96 – 27/09/96 : ASI/FIMSA/AMRAD Advanced course of Postgraduates in Immunology held at john Curtin School of Medical Research, Canberra, Australia.

05/02/96 – 17/02/96 : National Workshop on Techniques in Donor Selection during Transplantation. AIIMS, New Delhi, India (teaching Faculty).

09/93 – 10/93 : Isoelectric focusing for the determination of HLA-B27 variants, Dept. of transplantation Immunology, Central Laboratory of the Netherlands red Cross Blood Transfusion Service, Amsterdam, The Netherlands with Prof. TEW Feltkamp, Dr. Leo de Waal.

31/12/89 – 13/1/90 : Training workshop on HLA-DNA Technology (sponsored by DBT & NIH) HLA Laboratory, AIIMS, New Delhi, India.

POSITIONS OF SCIENTIFIC BODIES

Councilor from India	Australasian and South East Asian Tissue Typing Association (ASEATTA) since 2001-2010
Councillor –Asia Pacific region	Asia Pacific Histocompatibility and Immunogenetics Association (APHIA) 2010-2014
Founder secretary	Indian Society for Histocompatibility and Imunogenetics ISHI)
Member of the International Advisory Board	7^th Asia Oceania Histocompatibility Workshop, Japan
Executive committee member	Indian Immunology Society (IIS) in 2002
Life member	· Indian Immunology Society · Indian Society for Organ Transplantation · Indian Society for Histocompatibility and Imunogenetics (ISHI) · Indian Rheumatology Society · Australasian & South East Asian Tissue Typing Association (ASEATTA) · Delhi Nephrology Society · National Thalassemia Society · Asia Pacific Histocompatibility and Immunogenetics Association (APHIA)

Academic Responsibility

Journal Reviewer: I regularly review articles for journals several scientific journals like

Blood
Human Immunology
Tissue Antigens
International Journal of Immunogenetics
Case Reports in Immunology
Indian Journal of Hematology and Blood Transfusion

Research Grant review Committee

Task Force member- `Chronic Disease Biology’ Task Force, Department of Biotechnology, Govt of India. The committee reviews the research proposals in the area of autoimmune diseases, renal biology and cancer.

Administrative Responsibility : Coordinator of Departmental Academic Committee, General Coordination Committee, Purchase and Finance Committee

Social Service :Donor Recruitment In-charge and Donor Search Coordinator for `Asian Indian Donor Marrow Registry’Awareness programs for Marrow Donation at Gargi College, Railway Hospital, AIIMS, Friends Colony Club, Corporates in NOIDA.

RESEARCH PROJECTS

# as Principal Investigator, ** as Co-Principal Investigator * as Co-Investigator

SNo	Title of Project	Funding Agency	Duration	Funds ( lacs)	Status
1*	A study of genetic profile of chronic ITP patients at a North Indian Tertiary care centre	CSIR	2013-15	10.0	Ongoing
2*	Establishment of a Centre for Molecular Medicine at AIIMS	ICMR	2012-14	218.0	Ongoing
3#	Clinical significance of HLA-G in Hematopoietic Stem cell Transplantation	AIIMS	2012-14	10.0	Completed
4#	Impact of HLA-G on host immune response in human tuberculosis	ICMR	2012-15	54.2	Ongoing
5*	Asian Indian Donor Marrow Registry: Novel technologies, Genome Diversity & Transplant Immunology	DBT	2010-13	86.0	Completed
6*	Genomic analysis of MHC genes (HLA and non HLA) in Type 1 diabetes in the Indian population	ICMR	2007-10	68.0	Completed
7**	HLA profile of Raika community of Rajasthan	ICMR	2007-10	32.40	Completed
8*	Type 1 Diabetes Genetics Consortium-an international effort	NIH-JDRF	2005 –12	22.0	Completed
9*	Advance Program in Histocompatability and Transplant Immunology	DBT	2005-09	86.0	Completed
10*	Evaluation of immunological and cytopathological characteristics of first-degree relatives of patients of Juvenile autoimmune thyroiditis	INMAS	2005-06	3.0	Completed
11*	Humoral and Immunogenetic profile of Type 1 Diabetes in North Indians	ICMR-INSERM (Indo-French)	2003-06	25.0	Completed
12#	Heterogeneity of HLA-B27 gene in the Indian population	DBT	2000-03	16.8	Completed

Manuscript submitted

1. Srivastva A, Kanga U, Behari M, Mourya M. Stevens – Johnson syndrome (SJS) caused by addition of Levetiracetam to Carbamazepine, which drug is the villain of case? Seizure. 2014

Publications ( total 39)

1. Raina A, Chaudhary G, Dogra TD, Khandelwal D, Balayan A, Jain V, Kanga U, Seth T. Benefit of STR-based chimerism analysis to identify TA-GVHD as a cause of death: Utility of various biological specimens. Med Sci Law. 2015 Apr 6. pii: 0025802415577457. [Epub ahead of print] PubMed PMID: 25852093.

2. Bhat DK, Kanga U, Kumar N, Agrawal RP, Mourya M, Kaur T, Mehra NK. The Raikas – a unique combination of high prevalence of type 1 diabetes susceptibility genes and near zero incidence of the disease. Journal of Human Immunology. 2014 Dec; 75(12): 1252-8. PubMed PMID: 25312801.

3. Kumar N, Kaur G, Kanga U, Tandon N, Caillat-Zucman S, Mehra NK. Association of PTPN22+1858C/T polymorphism with Type 1 diabetes in the North Indian population. Int J Immunogenet. 2014 Aug;41(4):318-23. doi: 10.1111/iji.12129. Epub 2014 Jun 10. PubMed PMID: 24913133.

4. Malaviya AN, Sawhney S, Mehra NK, Kanga U. Seronegative arthritis in South Asia: an up-to-date review. Curr Rheumatol Rep. 2014 Apr;16(4):413.doi:10.1007/s11926-014-0413-z. Review. PubMed PMID: 24515283.

5. Kumar N, Kaur G, Tandon N, Kanga U, Mehra NK. Genomic evaluation of HLA-DR3+ haplotypes associated with type 1 diabetes. Annals of the New York Academy of Sciences, 2013, Feb 6. doi: 10.1111/nyas.12019.

6. Riccio ME, Buhler S, Nunes JM, Vangenot C, Cuénod M, Currat M, Di D, Andreani M, Boldyreva M, Chambers G, Chernova M, Chiaroni J, Darke C, Cristofaro JD, Dubois V, Dunn P, Edinur HA, Elamin N, Eliaou JF, Grubic Z, Jaatinen T, Kanga U, Kervaire B, Kolesar L, Kunachiwa W, Lokki ML, Mehra N, Nicoloso G, Paakkanen R, Voniatis DP, Papasteriades C, Poli F, Richard L, Alonso IR, Slavcev A, Sulcebe G, Suslova T, Testi M, Tiercy JM, Varnavidou A, Vidan-Jeras B, Wennerström A, Sanchez-Mazas A. 16(th) IHIW: Analysis of HLA Population Data, with updated results for 1996 to 2012 workshop data (AHPD project report). Int J Immunogenet. 2012 Dec 22. doi: 10.1111/iji.12033. PMID: 23280239

7. Kanga U, Mourya M, Seth T, George J, Sood P, Sharma R, Saxena A, Mehra NK.Role of Killer Immunoglobulin-like Receptor (KIR) – Ligand interaction in HLA matched sibling Hematopoietic Stem Cell Transplantation outcome. Transplant Proceedings, 2012.Volume 44, Issue 4, 919–21.

8. Seth T, Kanga U, Sood P, Sharma V, Mishra P, Mahapatra M. Audit of peripheral stem cell transplant for aplastic anemia in multi-transfused and infected patients. Transplant Proceedings, 2012, Volume 44, Issue 4, 922–24.

9. Kanga U, McWhinnie AJ, Mourya M, Shaw BE, Madrigal JA, Mehra NK. A novel HLA-DPB1 allele, DPB1*125:01, identified by sequence-based typing in an Indian individual. Tissue Antigens. 2011 Jan;77(1):85-7.

10. Malaviya AN, Kanga U, Agarwal D, Sharma A, Rawat R, Kapoor S, Garg S, Mehra NK. Routine laboratory testing for HLA-B*27 gene: flowcytometry-based technique gives occasional false negative results. Indian Journal of Rheumatology, 2011, 6(3):161-163.

11. Hollenbach JA, Mack SJ, Gourraud PA, Single RM, Maiers M, Middleton D, Thomson G, Marsh SG, Varney MD; Immunogenomics Data Analysis Working Group.Collaborators (Erlich HA, Feolo M, Fernandez-Viña M, Gourraud PA, Helmberg W, Kanga U, Kupatawintu P, Lancaster AK, Maiers M, Maldonado-Torres H, Marsh GE, Meyer D, Middleton D, Müller CR, Nathalang O, Park MH, Single RM, Tait B, Thomson G, Varney MD). A community standard for immunogenomic data reporting and analysis: proposal for a STrengthening the REporting of Immunogenomic Studies statement. Tissue Antigens. 2011 Nov;78(5):333-44. doi: 10.1111/j.1399-0039.2011.01777.x.

12. Hunt KA, Smyth DJ, Balschun T, Ban M, Mistry V, Ahmad T, Anand V, Barrett JC, Bhaw-Rosun L, Bockett NA, Brand OJ, Brouwer E, Concannon P, Cooper JD, Dias KR, van Diemen CC, Dubois PC, Edkins S, Fölster-Holst R, Fransen K, Glass DN, Heap GA, Hofmann S, Huizinga TW, Hunt S, Langford C, Lee J, Mansfield J, Marrosu MG, Mathew CG, Mein CA, Müller-Quernheim J, Nutland S, Onengut-Gumuscu S, Ouwehand W, Pearce K, Prescott NJ, Posthumus MD, Potter S, Rosati G, Sambrook J, Satsangi J, Schreiber S, Shtir C, Simmonds MJ, Sudman M, Thompson SD, Toes R, Trynka G, Vyse TJ, Walker NM, Weidinger S, Zhernakova A, Zoledziewska M; Type 1 Diabetes Genetics Consortium (T1DGC); UK Inflammatory Bowel Disease (IBD) Genetics Consortium; Wellcome Trust Case Control Consortium, Weersma RK, Gough SC, Sawcer S, Wijmenga C, Parkes M, Cucca F, Franke A, Deloukas P, Rich SS, Todd JA, van Heel DA. Rare and functional SIAE variants are not associated with autoimmune disease risk in up to 66,924 individuals of European ancestry. Nature Genet. 2011 Dec 27;44(1):3-5.

* Kanga U is T1DGC member

13. Hilner JE, Perdue LH, Sides EG, Pierce JJ, Wägner AM, Aldrich A, Loth A, Albret L, Wagenknecht LE, Nierras C, Akolkar B; T1DGC. Designing and implementing sample and data collection for an international genetics study: the Type 1Diabetes Genetics Consortium (T1DGC)*. Clin Trials. 2010;7(1 Suppl):S5-S32. Epub 2010 Jul 5. PubMed PMID: 20603248. * Kanga U is T1DGC member

14. Barrett JC, Clayton DG, Concannon P, Akolkar B, Cooper JD, Erlich HA, Julier C, Morahan G, Nerup J, Nierras C, Plagnol V, Pociot F, Schuilenburg H, Smyth DJ, Stevens H, Todd JA, Walker NM, Rich SS; Type 1 Diabetes Genetics Consortium*. Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes. Nature Genet. 2009 Jun;41(6):703-7. Epub 2009 May 10. PubMed PMID: 19430480; PubMed Central PMCID: PMC2889014. * Kanga U is T1DGC member

15. Kanga U, A Panigrahi, S Kumar, NK Mehra. The Asian Indian Donor Marrow Registry- AIIMS experience. Transplant Proceedings, 2007 Apr;39(3):719-20.

16. Mehra NK, Kumar N, Kaur G, Kanga U, Tandon N. Biomarkers of susceptibility to type 1 diabetes with special reference to the Indian population. Indian Journal of Medical Research, 2007, 125:321-344.

17. Steenkiste A, Valdes AM, Feolo M, Hoffman D, Concannon P, Noble J, Schoch G, Hansen J, Helmberg W, Dorman JS, Thomson G, Pugliese A; 13th IHWS Type 1 Diabetes Component participating investigators*. 14th International HLA and Immunogenetics Workshop: Report on the HLA component of type 1 diabetes. Tissue Antigens. 2007 Apr;69(s1):214-225. NK Mehra and Kanga U are participating Investigators.

18. Kanga U, Tandon N, Marwaha RK, Khanna R, Bhattacharya B, Singh S, Kumar N, Mehra NK. Immunogenetic association and Thyroid autoantibodies in Juvenile Autoimmune Thyroiditis in North India. Clinical Endocrinology, 2006,64 (5): 573-579.

19. Concannon P, Erlich HA, Julier C, Morahan G, Nerup J, Pociot F, Todd JA, Rich SS; Type 1 Diabetes Genetics Consortium*.Type 1 diabetes: evidence for susceptibility loci from four genome-wide linkage scans in 1,435 multiplex families. Diabetes. 2005 Oct;54(10):2995-300. *Kanga U is a T1DGC.

20. Kanga U, Vaidyanathan B, Jaini R, Menon PSN, Mehra NK. HLA haplotypes associated with Type 1 Diabetes mellitus in North Indians. Human Immunology 2004 Jan; 65(1): 47-53.

21. Witt CS, Price P, Kaur G, Cheong K, Kanga U, Sayer D, Christiansen FC, Mehra NK. The common HLA-B8-DR3 haplotype in North India is different from that found in Europe. Tissue Antigens 2002 ;60:474-480.

22. Jaini R, Naruse T, Kanga U, Eikkawa E, Kaur G, Inoko H, Mehra NK. Molecular diversity of the HLA-A*19 group of alleles in North Indians: possible oriental influence. Tissue Antigens, 59:487-91, 2002.

23. Panigrahi A, Agarwal SK, Kanga U, Guleria S, Bhowmik D, Dash SC, Gupta S, Tiwari SC, Mehta SN, Mehra NK. HLA Compatibility and Renal Graft Survival using unrelated donors: single centrs experience in India. Indian J Med Res, 115:158-164, 2002.

24. Mehra NK and Kanga U. Molecular Diversity of the HLA-B27 gene and its association with disease. Modern Rheumatology 11; 275-285, 2001.

25. Mehra NK, Kaur G, Kanga U, Tandon N. Immunogenetics of autoimmune diseases in Asian Indians. Annals N.Y. Acad Sciences, 958:333-336, 2001.

26. J Martinez-Borra, Segundo Gonzalez, A Lopez-Vazquez, MA Gelaz, J Bruges Armas, Kanga U, NK Mehra, C Lopez Larrea. HLA-B27 alone rather than B27-related haplotypes contributes to ankylosing spondylitis susceptibility. Human Immunology 2000, 61:131-139.

27. Jain S, Padma MV, Kanga U, Puri A, Mehra NK, Maheshwari MC. Family studies and Human Leukocyte Antigen class II typing in Indian probands with seizures and single small enhancing Computed Tomography lesions. Epilepsia , 1999 ,40(2) : 232-238.

28. Mehra NK, Jaini R, Balamurgum A, Kanga U, Prabhakaran D, Jain S, Talwar KK, Sharma BK. Immunogenetic analysis of Takayasu arteritis in India. International Journal of Cardiology 1998 , 66(SUPPL 1): S127-S132.

29. Jain S, Padma MV, Kanga U, Puri A, Mehra NK, Maheshwari MC. Occurrence of seizure types and HLA studies in Indian probands with seizures and single small enhancing CT lesions. Journal of Epilepsy 1997,10:55-61.

30. Kanga U, Mehra NK, Larrea CL, Lardy NM, Kumar A, Feltkemp TEW. Seronegative spondy loarthropathies and HLA-B27 subtypes: A study in Asian Indians. Clinical Rheumatology, 1996,15:13-18.

31. C.Lopez Larrea, K.Sujirachato, NK Mehra, P Chewsilp, D Isarangkura, U Kanga, O. Dominiguez,E.Coto, M Pena, F.Setien, S.Gonzalez-Roces. HLA B27 subtypes in Asian patients with Ankylosing Spondylitis, Evidence for new associations. Tissue Antigens,1995;45:169-176.

PUBLICATIONS (other journals - 8)

32. G Kaur, N Kumar, U Kanga, N Tandon, NK Mehra. Immunogenetic aspects of Autoimmune diseases. Proceedings of the 11^th Annual Symposium, Ranbaxy Science Foundation, 2006, page 45-52.

33. Mehra NK, Kaur G, Kaur J, Kalia R, Kanga U. Hematopoietic stem cell transplantation: strategies for expansion of HLA compatible donor pool. Proceedings of the 11^th Annual Symposium, Ranbaxy Science Foundation, 2005, page 111-118.

34. Jaini R, Kaur G, Kanga U, Mehra NK. External Genetic influences on MHC diversity in Asian Indians. HLA 2002. Handbook of the XIIIth International Histocompatibility Workshop and Congress.

35. A.Pugliese, J.S. Dorman, A. Steenkiste, H. Li, E. Thorsby, M. Lathrop, G. Schoch, G. Thomson, S. Caillat-Zucman,Z. Awdeh, S. Babu, M. Berrino, B. Bohm, C. Brautbar, B. Calvo, L. Castano, F. Christiansen, L.M. Chuang, G.S. Eisenbarth, F. El Chenawi, P. Fain, I. Fajardy, M. Fasano, D. Fici, K. Gillespie, C. Gorodezky, L. Harrison, M. Honeyman, H. Ikegami, J. Ilonen, S. Israel, U. Kanga, B. Koeleman, A. Lernmark, B. Lie, M. Martinetti, N. Mehra, V. Mohan, A. Moine, W. Mynarski, E. Naumova, J. Nerup, F. Pociot, R. Rani, B. Roep, C.B. Sanjeevi, G. Sahuran-Direskeneli, G. Semana, H. Stevens, B. Tait, J. Todd, E. Tuomilehto-Wolf, D. Undlien, P. Vardi, W. Volpini, M. Zarghami. JOINT REPORT OF THE 13th IHWS TYPE 1 DIABETES (T1D) COMPONENT. HLA 2002. Handbook of the XIIIth International Histocompatibility Workshop and Congress.

36. Toubert A, Reveille J, Gorodezky C, Mehra NK, Tamouza R, Thomson G, Li H, Akey JM, Lathrop M, Thorsby E and 13^th. IHWG spondyloarthropathies component laboratories^*,**,***,****. Report from the 13 IHWC spondyloarthropathies component. In:HLA 2002. Eds. John A Hansen and Bo Dupont, 2003. **** Studies from India : Dr. NK Mehra and Dr. U Kanga

37. Kanga U, Ritika Jaini, Rajeev Kalia, NK Mehra. Asian Indian donor marrow registry : an alternate source of HLA matched donors for bone marrow transplantation. Proceedings of the 8^th Annual Symposium, Ranbaxy Science Foundation, 2002; 65-76.

38. Mehra NK, Rajalingam R, Kanga U, McEneny L, Cullen C, Agarwal S, Middleton D, Pollack MS, Amirzargar A, Singal DP. Genetic diversity of HLA in the populations of India, Sri Lanka and Iran. In: Genetic Diversity of HLA: Functional and Medical Implications, Vol.I. eds. Dominique Charron, EDK Publishers, Paris, 1996, Vol 1: 314-320.

39. NK Mehra, V Taneja and U Kanga. Immunogenetics of Rheumatic Diseases in India. Proceedings of the Fourth Asean Congress of Rheumatology, 31st October-4th November 1993, Singa pore, Communication Consultants, Singapore 1993.

Indexed Abstracts- 10

Other Abstracts- 70

Book Chapters- Four

1. Mehra NK and Kanga Uma. HLA matched donors for Thalassemics requiring Bone Marrow Transplantation. Thalassemia Bulletin, New Delhi, Vol 4, No 2, June 1998.

2. Mehra NK, Kanga U, Tiwari S. HLA Matched Donors for Thalassaemia Patients: Role of Asian Indian Donor Marrow Registry (AIDMR), proceedings 4^th National Thalassemia Conference, AIIMS, 2003.

3. Uma Kanga and NK Mehra. HLA matching in hematopoietic stem cell transplantation. Proceeding of the Hematopoietic Stem Cell Transplant Workshop, 2004, AIIMS, New Delhi.

4. Kanga Uma, Mehra Narinder K. Donor selection strategies for hematopoietic stem cell transplantation. In: The HLA Complex in Biology and Medicine : A Resource book. Eds. N.K Mehra, G Kaur, McCluskey J, Christiansen F, Claas F. Jaypee Brothers Medical Publishers (P) Ltd, New Delhi, P449-464, 2010.

INTRODUCTORY VIDEO

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{loadposition iframeHLA_intro}

Students

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Students

S. No.	Name	Designation	Email
1	Ms. Girji Mehta	Ph.D	girijamehta2020@gmail.com
2	Ms. Shivani Kaushik	Ph.D	Shivanikaushik72@gmail.com

Staff

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Administrative Office/Secretarial Staff

S. no.	Name	Designation	Email
1	Ms. Yogita Arora	Personal Assistant	arorayogita8@gmail.com
2	Mr. Mahender Singh,	Jr. Admin. Officer	aiims.mahender@yahoo.com
3	Mr. Prakash Sharma	Sr. Admin Assist.	prakashsharma80@gmail.com
4	Mr. Arvind Kumar	Jr. Admin Assist.	arvindc310@gmail.com
5	Mr. Tarun Kumar Pali	D.E.O	tarunpalionline@gmail.com

Office email. ID

deptofimmunology2015@gmail.com

Laboratory Staff

S. no.	Name	Designation	Email
1	Ms. Ajeet Alwadhi	Sr. Tech. Officer	ajeetalwadhi1967@gmail.com
2	Mr. Shekhar Neolia	Sr. Tech. Officer	shekharaiims@rediffmail.com
3	Ms. Esther Philip	Sr. Tech. Officer	estherphilip104@gmail.com
4	Mr. Mohan Kumar	Med. Lab. Tech.	kumarmohan0874@gmail.com
5	Mr. Gagan Sharma	Med. Lab. Tech.	gagansharma118@gmail.com
6	Mr. Shashi Kapoor Gautam	Med. Lab. Tech.	shashikapoor06@gmail.com
7	Mohd. Abid	Med. Lab. Tech.	abidmultani@gmail.com
8	Mr. Vikash Kumar	Med. Lab. Tech.	vikashkumaraiims@gmail.com
9	Mr. Gurpal	Med. Lab. Tech.	gurpalvaid@gmail.com
10	Mr. Manish Dogra	Med. Lab. Tech.	manishdograaiims@yahoo.com

Office Attendant

S. no.	Name	Designation
1	Mr. Mukesh Kumar	Office Attendant Gr-II
2	Mr. Rattan Lal	Office Attendant Gr-I

Sanitary Staff

S. No.	Name	Designation
1	Mr. Om Prakash	M.T.S. (Sanitation)

Administrative Office/Secretarial Staff

S. no.	Name	Designation	Email
1	Ms. Yogita Arora	Personal Assistant	arorayogita8@gmail.com
2	Mr. Mahender Singh,	Jr. Admin. Officer	aiims.mahender@yahoo.com
3	Mr. Prakash Sharma	Sr. Admin Assist.	prakashsharma80@gmail.com
4	Mr. Arvind Kumar	Jr. Admin Assist.	arvindc310@gmail.com
5	Mr. Tarun Kumar Pali	D.E.O	tarunpalionline@gmail.com

Office email. ID

deptofimmunology2015@gmail.com

Laboratory Staff

S. no.	Name	Designation	Email
1	Ms. Ajeet Alwadhi	Sr. Tech. Officer	ajeetalwadhi1967@gmail.com
2	Mr. Shekhar Neolia	Sr. Tech. Officer	shekharaiims@rediffmail.com
3	Ms. Esther Philip	Sr. Tech. Officer	estherphilip104@gmail.com
4	Mr. Mohan Kumar	Med. Lab. Tech.	kumarmohan0874@gmail.com
5	Mr. Gagan Sharma	Med. Lab. Tech.	gagansharma118@gmail.com
6	Mr. Shashi Kapoor Gautam	Med. Lab. Tech.	shashikapoor06@gmail.com
7	Mohd. Abid	Med. Lab. Tech.	abidmultani@gmail.com
8	Mr. Vikash Kumar	Med. Lab. Tech.	vikashkumaraiims@gmail.com
9	Mr. Gurpal	Med. Lab. Tech.	gurpalvaid@gmail.com
10	Mr. Manish Dogra	Med. Lab. Tech.	manishdograaiims@yahoo.com

Office Attendant

S. no.	Name	Designation
1	Mr. Mukesh Kumar	Office Attendant Gr-II
2	Mr. Rattan Lal	Office Attendant Gr-I

Sanitary Staff

S. No.	Name	Designation
1	Mr. Om Prakash	M.T.S. (Sanitation)

Publications

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PUBLICATIONS

1. Jaini R, Naruse T, Kanga U, Eikkawa E, Kaur G, Inoko H, Mehra NK. Molecular diversity of the HLA-A*19 group of alleles in North Indians: possible oriental influence. Tissue Antigens, 59:487-91, 2002.

2. Mehra NK, Kaur G, Jaini R. Genetic diversity in the human major histocompatibility complex (MHC): lessons for vaccination approaches to HIV infection. Community Genet 5:162-66, 2002.

3. Witt CS, Price P, Kaur G, Cheong KML, Christiansen FT, Mehra NK. The common HLA-B8-DR3 haplotype in Northern India is distinct from that found in Europeans. Tissue Antigens. 60:474-80, 2002

4. Kaur G, Sarkar N, Bhatnagar S, Kumar S, Rapthap CC, Bhan MK, Mehra NK. Paediatric celiac disease in India is associated with multiple DR3-DQ2 haplotypes. Human Immunol 63: 677-682, 2002.

5. Sharma SK, Balamurugan A, Saha PK, Pandey RM, Mehra NK. Evaluation of clinical and immunogenetic risk factors for the development of hepatotoxicity during antituberculosis treatment. Am J Respir Crit Care Med. 165:1-4, 2002.

6. Sharma SK, Mitra DK, Balamurugan A, Pandey RM, Mehra NK. Cytokine polarization in miliary and pleural tuberculosis. J Clin Immunol, 22:345-52,2002.

7. Panigrahi A, Agarwal SK, Kanga U, Guleria S, Bhowmik D, Dash SC, Gupta S, Tiwari SC, Mehta SN, Mehra NK. Influence of HLA compatibility on renal graft survival using unrelated and cadaver donors in India. Indian J Med Res, 115:158-164, 2002.

8. Deka R, Panigrahi A, Agarwal S, Guleria S, Dash SC, Mehta SN, Pandey RM, Mehra NK. Influence of Pretransplant panel reactive antibodies on the post transplant sensitization status. Transplantation Proceed, 34:3082-83, 2002.

9. Chopra G.S, Diwan R.N, Mehra NK. Role of molecular typing in live related donor renal transplantation. Med J. Armed Forces India. 58;201-204,2002.

10. Witt C, Cheong K, Kaur G, Kanga U, Price P, Mehra NK, Sayer D, DeSantis D, Christiansen F. HLA-B8 & DR 3 associated with IDDM in Europeans and Northern Indians but are on different haplotyes in these populations. Tissue Antigens 59(Suppl): 21,2002.

11. Mehra Raj D, Kaushal RK, Sagar R, Kaur G, Malhotra S, Sharma K, Mitra DK, Mehra NK. Immunogenetic Analysis of Asian Indian Autistic Children. Tissue Antigens 59 (Suppl) : 70-71, 2002.

12. Jaini R, Neolia S, Philip E, Kanga U, Kaur, Mehra NK. External Genetic Influences on MHC Diversity in Asian Indians. Tissue Antigens 59 (Suppl): 99, 2002.

13. Panigrahi A, Deka R, Mehra NK. Clinical Relevance of Donor and Non-Donor specific anti HLA class-I Antibodies in live related Donor Renal Transplantation. Tissue Antigens 59 (Suppl): 125, 2002.

14. Kanga U, Kumar A, Agrawal S, Kanokar SR, Mehra NK. Heterogeneity of HLA-B27 group of allele in Asian Idians. Tissue Antigens 59 (Suppl): 131, 2002.

15. Mehra NK, Balamurugan A, Singh M, Mitra DK, Sharma SK, Sengupta U. Pocket ‘1’ and ‘4’ residues in DRB1 molecules modulate immune response in mycobacterial infection. Tissue Antigens 59 (Suppl): 135, 2002.

16. Kaur G, Sarkar N, Bhatnagar S, Kumar S, Rapthap CC, Bhan MK, Mehra NK. Paediatric celiac disease in India is associated with multiple DR3-DQ 2 haploytes. Tissue Antigens 59 (Suppl) : 140, 2002.

17. Bhowmik D, Dash SC, Guleria S, Panigrahi A, Gupta S, Agarwal S, Tiwari SC, Mehta SN and Mehra N.K. Spousal Renal Transplants: Implications in Developing Countries. Transplantation Proceed 35:26-27,2003.

18. Basak U, Mitra DK, Panigrahi A, Guleria S, Agarwal S, Mehta SN, Dash SC, Mehra NK. Clinical relevance of monitoring cytokine production following live donor renal transplantation. Transplantation Proceed 35: 404-406, 2003.

19. Mehra NK, Kaur G. MHC based vaccination approaches: progress and perspectives. Expert Reviews in Molecular Medicine 5; 1-17, 2003. (http://www.expertreviews.org/03005957h.htm)

20. Kanga U, Jaini R, Kalia R,. Mehra NK. Asian Indian Donor Marrow Registry: an alternate source of HLA matched donors for bone marrow transplantation. In: Advances in Hematopoietic Stem Cell Transplantation eds: N.K. Mehra, O.P. Sood, published by Ranbaxy Science Foundation, Gurgaon, India p65-75, 2002.

21. Mehra NK, Singh M. Immunological mechanisms underlying relapse of original cancer: experience from autologous peripheral blood stem transplantation In: Advances in Hematopoietic Stem Cell Transplantation eds: N.K. Mehra, O.P. Sood, published by Ranbaxy Science Foundation, Gurgaon, India p109-117, 2002.

22. Kaur G, Rapthap CC, Mehra NK. Molecular analysis of chimerism following bone marrow transplantation In: Advances in Hematopoietic Stem Cell Transplantation eds: N.K. Mehra, O.P. Sood, published by Ranbaxy Science Foundation, Gurgaon, India p119-127, 2002.

23. Mehra NK. Opening Remarks In: Advances in Hematopoietic Stem Cell Transplantation eds: N.K. Mehra, O.P. Sood, published by Ranbaxy Science Foundation, Gurgaon, India p1-3, 2002.

24. Mehra NK. Chapter on Transplantation Immunology and Clinical immunogenetics. In: API Textbook of Medicine, 7^th edition, editor-in-chief , Siddharth N. Shah, p23-30, 2003.

25. Mehra NK, Kaur G. Genomics and immune response: opportunities and risks. In Proceedings ICMR Symposium on Ethical, legal and social issues on Genomics, ICMR Publication, 2003.

Awards And Honours

Prof. N.K. Mehra received the chief of the Army Staff Award in February 2003. He was elected ‘International Councillor for the prestigeous International Histocompatibility Workshops. He continues to be the 'council member' of the International union of Immunological Societies (IUIS), Vice President of the Federation of Immunological Societies of Asia-Oceania (FIMSA) and as international councillor for the Australasian and South East Asian Tissue Typing Association (ASEATTA). He serves as the 'Honorary Consultant' to the Armed Forces Medical Services (AFMS), a trustee of the Immunology Foundation India, member of the DBT Task Force on Human Resource Development, and Human Genetics and Genome analysis, member of the Scientific Advisory Committee of JALMA Institute for Leprosy, Agra and Institute of Cytology and Preventive Oncology (ICPO), New Delhi, member of the Advisory Board of the Special Centre for Molecular Medicine, Jawaharlal Nehru University, New Delhi. member of the Board of Studies in Human Genetics of the Guru Nanak Dev University (GNDU), Amritsar, member of the ICMR Task Force on Immunology and of Project review committees of the ICMR, member of BHU Advisory Board for Molecular Genetics.

Prof. N.K. Mehra is on the Editorial Board of several prestigeous international journals: Microbes and Infection (Pasteur Institute, Paris), Tissue Antigens (Australia), Modern Rheumatology (Japan), International journal of Human Genetics (India), Journal of Clinical Immunology (USA). He was invited Guest speaker at the inaugural scientific meeting of the Allergy and Immunology Society of Srilanka (ALSSL) and at the Braunschweig Streptococcal colloquium, Branschweig, Germany. Professor Mehra is a member of the ethical, legal and social implications (ELSI) Committee of the Type 1 Diabetes Genetics consortium (T1DGC) of the NIH, Washington, USA. He was elected as Vice President of the Indian Society of Organ Transplantation (ISOT).

Dr. Uma Kanga (Scientist II) serves as the ‘Councillor’ for the Australasian and South East Asian Tissue Typing Association (ASEATTA).

Visiting Scientists

Dr Beverly Smith Keiling (USA), Dr Andreas D Keling (USA), Prof John Fahey (USA), Dr Jaspal Kaeda (UK), Dr Nikolai Petrovasky (Australia). Dr. Sudhir Gupta (USA), Dr Sophie Caillat Zucman (France).

Significant Events

The department has established several new technologies including ELISA-PRA and Flow-PRA, for assessment of graft dysfunction following renal and bone marrow transplantation. Chimerism analysis following BMT is also performed to assess the engraftment status of the recipient. These tests are very informative for post transplant monitoring. The services are offered for patient care purposes on routine basis.

Research

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RESEARCH

Completed Projects

Project Title	PI	Funding Agency	Total Funding	Duration
Advanced Program in Histocompatibility & Transplant Immunology (APHTI)	Prof N.K Mehra	DBT	68.17 lacs	2000-02

Ongoing Projects

Project Title	Principal Investigator(s)	Funding Agency	Total Funding	Duration
Advanced Programming Histocompatibility & Transplantation Immunology (APHTI)- Contd for another 2 years	Prof N.k Mehra	DBT	17.0 lacs	2003-05
Heterogenetiy of HLA-B27 gene in the Indian Population	Dr Uma Kanga & Prof. N.K Mehra	DBT	16.01 lacs	2000-03
Human Genome Diversity: HLA studies	Prof . N.K Mehra	DBT	30.56 lacs	2001-04
Immunogenetics of mycobacterial diseases : A 13th IHWC international study	Prof. N.K Mehra	ICMR	18.35 lacs	2001-04
Evaluation of virus specific response in HIV-I subtype C infected individuals in North India (HLA Component)	Prof N.K Mehra	DBT	15.5 lacs	2002-04
Molecular analysis of Cytokine gene polymorphism in leprosy	Prof. N.K Mehra	ICMR	26.48 lacs	2002-05
Immunogenetic and Humoral Profile of Type 1 Diabetes in Indian Population	Prof . N.K Mehra	ICMR	24 lacs	2003-06
Evaluation of immunological and cytopathological characteristics of first-degree relatives of patients of Juvenile autoimmune thyroiditis	Prof. N.K Mehra	INMAS	3 lacs	2003-05

Collaborative Research Projects

Project Title	Name of collaborative department
Evaluation of virus specific response in HIV-I subtype C infected individuals in North India (HLA Component)	Dept. Of Microbiology,AIIMS
Immunogenetics and Humoral Profile of Type I Diabetes in Indian Population	Dept of Endocrinology AIIMS , Laboratoire d' Immunologie, INSERM ,Paris
Molecular Analysis of Cytokine gene polymorphism in leprosy	Centre JALMA Institute for Leprosy (JALMA) ,Agra
Evaluation of immunological and cytopathological characterstics of first degree relatives of patients of Juvenile sutoimmune throiditis'	Institute of Nuclear Medicine and Allied Sciences (INMAS) , New Delhi
An Evaluation of Immunological Predictors of Graft dysfunction following renal transplantation	Department of Nephrology and General Surgery, AIIMS

Patient care

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PATIENT CARE (Laboratory Services)

TRANSPLANTATION

HLA Matching

	Recipents	Donors	Total
Renal Transplant Patients	200	225	425

Bone Marrow Transplant Patients

Leukimas	62	260	322
Aplastic Anemia	20	65	85
Thalassemias	22	55	77
Others	23	60	83
HLA-DNA Matching	125	175	300

Cadaver Dover Organ Transplantation

Cadaver Donor	5
Kidney Recipients	30
Heart Recipients	5

Cross Match Tests

Serology	267
Flowcytometry	30

Panel Reactive antibody(PRA) 300

DIAGNOSTICS

Spondyloarthropathies	356
Other disease	85

New Technologies for Patient Services

Flow PRA	70
ELISA PRA	70
Chimerism Studies in BMT	85	90	175

Unrelated Donor Search for BMT

During the year, a total of 260 requests for search of unrelated HLA matched Donor from the 'Asian Indian Donor Marrow Registery ' for bone marrow transplantation(BMT) were received. These include 120 from USA , 65 from Europe , 27 from various Asian Countries and 48 from India.

Education

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EDUCATION

The Department Provides short term training to junior residents of Pathology and Laboratory medicine and Senior Residents (DM Students ) of the Department of Hematology . Two Graduate and two postgraduate students from the various other departments of AIIMS received short term training . Four students from various universities , three doctors from other hospitals in Delhi and one doctor from Dhaka, Bangladesh attended 4-6 months training in the Laboratory techniques of HLA testing . During the year, three students completed their Ph.D and were awarded.

Continuing Medical Education(CME)

The Faculty of the department participated in and delivered 40 lectures in Continuing education programs , symposia, national and international conferences during the year. A quality control exercise for DNA typing of HLA genes has been started at the national level. The department provides a course on basic and clinical immunogenetics for M.Sc students of University of Delhi (South Campus) and Banaras Hindu University

Faculty

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Faculty

S. No.	Name	Designation	Email
1	Dr. D.K. Mitra	Professor & Head	salilmitra2@gmail.com
2	Dr. Uma Kanga	Addl. Professor	umakanga24@gmail.com
3	Dr. Rakesh Kumar Deepak	Addl. Professor	rakeshdeepak2008@gmail.com

Scientist

S. No.	Name	Designation	Email
1	Dr. Sunil Kumar	Scientist-II	sabkamalikek09@hotmail.com
2	Dr. Lata Kumari	Scientist-II	latahp@gmail.com
3	Dr. Sanjeev Goswami	Scientist-I	goswamisanjeev@yahoo.com
4	Dr. Prabin Kumar	Scientist-I	raiprabin79@gmail.com