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अखिल भारतीय आयुर्विज्ञान संस्थान, नई दिल्ली
All India Institute Of Medical Sciences, New Delhi
कॉल सेंटर:  011-26589142

Hospital Statistics 2015-16

Alumini

EX-STUDENTS

Dr. Chriasturajan Soundara Rajan

Ph.D, Thesis on Molecular study on mitochondrial dysfunction in Parkison’s disease

Worked as Biochemist at Centralised Laboratory, CN Centre,AIIMS (2002- 2006)

Present Status: Post Doctoral Fellow at John Hopkins’s University, USA

email: यह ईमेल पता spambots से संरक्षित किया जा रहा है. आप जावास्क्रिप्ट यह देखने के सक्षम होना चाहिए.

 

Dr. Hamid Suhail

Ph.D Thesis: Comparative studies of antibodies to nicotine Acetylcholine Receptors (nAChRs) and muscle specific tyrosine Kinase (MuSK) in Myasthenia Gravis patients with clinical correlation in context with genotype and phenotype variation

Present Status: Post Doctoral Fellow at Canada

email: यह ईमेल पता spambots से संरक्षित किया जा रहा है. आप जावास्क्रिप्ट यह देखने के सक्षम होना चाहिए.

Dr. Muraleedharan Muniswamy

Ph.D Thesis: Pharmacogenetics of Epilepsy Drug Therapeutics

Present Status: Post Doctoral Fellow at Alabama, USA

email: यह ईमेल पता spambots से संरक्षित किया जा रहा है. आप जावास्क्रिप्ट यह देखने के सक्षम होना चाहिए.

Dr. Kanthaiah Y.V

Ph.D, Thesis: Analysis of Classical, Nonclassical MHC I, TGF beta in glioma stem cells, effect of IFN Gamma and IL-12 on these molecules and relevance in immunotherapy

Present Status: Clinical Scientist at Totipopent Rx Cell Therapy pvt ltd

email: यह ईमेल पता spambots से संरक्षित किया जा रहा है. आप जावास्क्रिप्ट यह देखने के सक्षम होना चाहिए.

Dr. Mohita Sriwastva

Ph.D, Thesis: Mitochondrial Dysfunction And its Role in the Genesis of programmed Cell Death (PCD) pathway in patients with Amyotrophic Lateral Sclerosis (ALS)

email: यह ईमेल पता spambots से संरक्षित किया जा रहा है. आप जावास्क्रिप्ट यह देखने के सक्षम होना चाहिए.

 

Dr. Gopishankar N

MSc Medical Physics and MCA

Ph.D Thesis: Validation of gel docimetry as a 3D verification tool in highly conformal radiotherapy techniques

Present Status: Medical pharmacist & RSO, AIIMS

email: यह ईमेल पता spambots से संरक्षित किया जा रहा है. आप जावास्क्रिप्ट यह देखने के सक्षम होना चाहिए. , यह ईमेल पता spambots से संरक्षित किया जा रहा है. आप जावास्क्रिप्ट यह देखने के सक्षम होना चाहिए.

 

Dr Saima Naz Siddiquie

Ph.D Thesis: Identification and analysis of specific nutritions in ATP7B, Hctr-1 and ATox-1 genes and study of their molecular genetics to establish genotype- phenotype correlation in Wilson Disease patients.

email: यह ईमेल पता spambots से संरक्षित किया जा रहा है. आप जावास्क्रिप्ट यह देखने के सक्षम होना चाहिए.

Dr. Hardeep S Gambhir

Ph.D Thesis: Implantation of human retinal pigment epithelial (hRPE) cells in the 6- OHDA Iesioned rat model of Parkison’s disease (PD)

email: यह ईमेल पता spambots से संरक्षित किया जा रहा है. आप जावास्क्रिप्ट यह देखने के सक्षम होना चाहिए.

SONALI NIRMAL

Area of Research: Pharmacogenetics study in Alzheimer’s disease

MSc in Biotechnology (Bharatidasan University, Tamil Nadu)

Email: यह ईमेल पता spambots से संरक्षित किया जा रहा है. आप जावास्क्रिप्ट यह देखने के सक्षम होना चाहिए.

projects

PROJECTS 

SL NO

PROJECT TITLE

FUNDING AGENCY

DURATION

        1

Immunologic and Immunogenetic aspects of Multiple sclerosis patients in India   

ICMR

1987 to 1990

2

Purine metabolic enzymes in peripheral blood T-cells in Multiple sclerosis patients

ICMR

1997 to 2000

Antioxidant status and genetically determined differences in xenobiotic  metabolism in Parkinsons disease

 

ICMR

1999 to 2002

  1. 4

Role of CYP2D6 and Glutathione S-transferase M1 (GSTM1) polymorphism in Multiple Sclerosis patients

 

ICMR

2001 to 2003

  1.  5

Impact of Nutritional strategies and antioxidant therapy on progression and  management of Parkinson,s disease

ICMR

2002 to 2004

  1.  6

Molecular study on mitochondrial dysfunction in Parkinson,s disease 

ICMR

2004 to 2006

  1.  7

Genetic polymorphism of drug metabolizing enzymes CYPC9 and CYPC19 genes in patients developing adverse drug reactions and toxicity to specific antiepileptic drug - Phenytoin

 

ICMR

2004 to 2007

  1.  8

To find out predominant mutation(s) in Cu/Zn SOD1 gene in Familial amyotrophic  lateral sclerosis patients and their first –degree relatives in Indian population

 

AIIMS

2006 to 2007

  1.  9

Health Profile of Population of Nellore  (A.P.) An ICMR task force study.

ICMR

2007 to 2008

10    10

Analysis of TGF B Pathway components expression and mutation in   glioma patients “

AIIMS

2007 to 2008

11    11

Health Profile of Population of Dhar (MP)

ICMR

2009 to 2010

1 .    12

Pharmacogenetic of epilepsy drug therapeutics

DBT

2007 to 2010

13    13

The study of mitochondrial dysfunction in patients with Amyotrophic Lateral  Sclerosis

ICMR

2007 to 2010

14   14

Validation of Gel dosimetry as 3D verification tool for highly conformal radiotherapy techniques

AERB

2009 to 2010

15     15   

Exploring the role of MHC and co-stimulatory molecules in immune evasion mechanism of Glioma stem cells.

DBT

2008 to 2011

16   16

Pharmacogenetics of Alzhemiers drug therapeutics

DST

2010 to 2014

17   17

Multi centric study on Pharmacogenetics of Schizophrenia drug therapeutics

ICMR

2011to 2015

Publications

PUBLICATION

 

1.      Amit Kumar, S Vivekanandhan, Arpna Srivastava, Manjari Tripathi, M. V. Padma Srivastava, Neha Saini, Pradeep Kumar, Kameshwar Prasad. Association between angiotensin converting enzyme gene insertion/deletion polymorphism and ischemic stroke in north Indian population:a case–control study and meta-analysis. Neurological Research 2014 , Feb.12

 

2.      Amit Kumar, Kameshwar Prasad, Manjari Tripathi, M.V Padma Srivastava, S. Vivekanadhan. Association of beta adrenergic receptor polymorphism with risk of hemorrhagic stroke in North Indian Population: A case control study. Neurology India, 2014.

 

3.      Identification of Genetic Contribution to Ischemic Stroke by screening of Single Nucleotide Polymorphisms in Stroke Patients by using a case control study design (Study protocol) and meta-analysis.  Amit Kumar, Pradeep Kumar, Jitendra Kumar Sahu, Ashoo Grover, Achal Srivastava, S Vivekanandhan and Kameshwar Prasad. BMC Neurology 2013 Oct.3:13:136

 

  1. J.Ghosh,R.K..Bikramjit Singh, R.Sexena, R.Gupta, S.Vivekanandhan, V.Sreenivas, V.Raina, A.Sharma, L.Kumar,  Prevalence and aetiology of anaemia in lymphoid malignancies. The National Medical Journal of India..Vol.26,No.2., 2013.

 

  1. Munisamy MTripathi MBehari MRaghavan SJain DCRamanujam BArumugam KRajakannan TMallayasamy SRSubbiah V.The effect of Uridine Diphosphate Glucuronosyltransferase (UGT)1A6 genetic polymorphism on Valproic acid Pharmacokinetics in Indian Patients with Epilepsy: A Pharmacogenetic Approach. Molecular Diagnosis & Therapy: Volume 17, Issue 5 (2013), Page 319-326.

 

  1. Shukla D, Kale AD, Hallikerimath S, Yerramalla V, Subbiah V, Mishra S. Association between GSTM1 and CYPA1 polymorphisms and survival in oral cancer patients- Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2013;157:XX.

 

7.      Sonali N, Tripathi M, Sagar R, Vivekanandhan S. Impact of CYP2D6 and CYP3A4 Genetic Polymorphism on Combined Cholinesterase Inhibitors and Memantine Treatment in Mild to Moderate Alzheimer? Disease. Dementia and Geriatric Cognitive disorders. 2014; 37: 58-70.

 

  1. N.Gopishankar, S.Vivekanandhan, G.K.Rath, M.A. Laviraj,S. Senthilkumaran, S.S.Kale, S.thulkar, R.K.Bisht, V.Subramani. Indigenously developed multipurpose acrylic head phantom for verification of IMRT using film and gel Dosimetry. Journal of Applied Clinical Medical Physics, Vol. 14, No.2, 2013.

 

  1. Sonali N, Tripathi M, Sagar R, Vivekanandhan S, Val66Met polymorphism and BDNF levels in Alzheimer’s disease patients in North Indian population. Int. J Neuroscience 2013 Feb. 4

 

10. Dalal,K; Elanchezhiyan D; Vivekanandhan S; Pandey R M;Tripathi M. Role of Reflexology and Antiepileptic Drugs in Managing Intractable Epilepsy -a Randomized Controlled Trial. Forschende Komplementärmedizin 2013; 20:104-111

 

11. Sonali N, Tripathi M, Sagar R, Velpandian T, Subbiah V."Clinical effectiveness of Rivastigmine monotherapy and combination therapy in Alzheimer’s patients" CNS Neuroscience & Therapeutics. CNS Neurosci Ther. 2013 Feb.19(2):91-7.

 

12. Dhandapani S, Dhandapani M, Agarwal M, Chutani AM, Subbiah V, Sharma BS, Mahapatra AK. The prognostic significance of the timing of total enteral feeding in traumatic brain injury. Surg Neurol Int. 2012; 3: 31.

 

13. Natanasabapathi GSubbiah VKale SSRath GKSenthilkumaran SThulkar SSubramani VLaviraj MABisht RKMahapatra AK. "MAGAT Gel and EBT2 film based Dosimetry for Evaluating Source plugging based treatment plan in Gamma Knife Stereotactic Radiosurgery". J Appl Clin Med Phys. 2012 Nov 8;13 (6):3877.

 

  1. 14.  Shukla D, Kale AD, Hallikerimath S, Vivekanandhan S, Venkatakanthaiah Y. Genetic polymorphism of drug metabolizing enzymes (GSTM1 and CYP1A1) as risk factors for oral premalignant lesions and oral cancer. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2012 Jan 30. doi: 10.5507/bp.2012.013.

 

15. Deepika Shukla, Seema Hallikerimath, Venkatakanthaiah Yerramalla, and Vivekanandhan Subbiah, Can Quantifying Free-Circulating DNA Be a Diagnostic and Prognostic Marker in Oral Epithelial Dysplasia and Oral Squamous Cell Carcinoma?  American Association of Oral and Maxillofacial Surgeons2012

 

16. Khan S, Behari M,  Vivekanandhan S, Goyal  V, Thelma BK. Mutation Profile in Wilson’s Disease from North Indian Patients. International Journal of Human Genetics ; 2012; 12 (2); 125-132

 

17. Sivashanmugam D, Manju D, Meena A, Alka MC, Vivekanandhan S, Bhawani SS, Ashok KM. The prognostic significance of the timing of total enteral feeding in traumatic brain injury. Surgical Neurology International ; 2012;  3 :31

18. Murali M, Manjari T, Madhuri B, Raghavan S, Jain DC and Vivekanandhan S. Genetic Polymorphism of NAT2 Metabolizing Enzymes on Phenytoin Pharmacokinetics in Indian Epileptic Patients Developing Toxicity. CNS Neurosci Ther; 2012 April 18 (4):350-8

 

19. Vivekanadhan S, Bhardwaj D, Munisamy M and Sagar R. Angiotensin Converting Enzyme Gene Insertion/Deletion Polymorphism: Case-Control Association with Schizophrenia in a North Indian Population.  J Mol Biomark Diagn ; 2011; (2); 105.

 

20. Nirmal S, Tripathi M, Shastri S, Sagar R and Vivekanandhan S. Association of angiotensin converting enzyme I/D genotype in Alzheimer’s Disease patients of  North Indian population. The International Journal of Neuroscience; 2011;  121 (10); 557-561

21. Tripathi M, Vibha D, Gupta P, Padma MV, Bhatia R, Prasad K, Singh MB and Vivekanandan S. Risk factors of dementia in North India: a case control study. Aging and Mental Health; June 2011; Epub DOI:10.1080/13607863.2011.583632

22. Srivastava M, Vivekanandhan S, Pathy U, Behari M and Das TK. Mitochondrial perturbance and execution of apoptosis in platelet mitochondria of patients with Amyotrophic lateral Sclerosis. International Journal of Neuroscience; 2011; 121(3); 149-158

 

23. Srivastava M, Das TK, Behari M and Vivekanandhan S. Ultrastructural variations in platelets and platelet mitochondria: a novel feature in amyotrophic lateral sclerosis. Ultrastruct Pathology; 2011; 35(2); 52-59

 

24. Srivastava M and Vivekanandhan S. An Insight into Ultrastructural and Morphological Alterations of Platelets in Neurodegenerative Diseases.  Ultrastruct Pathol; 2011; 35(3); 110–116

 

25. Gopishankar N, Watanabe Y and Vivekanandhan S. MRI-based polymer gel dosimetry for validating plans with multiple matrices in Gamma Knife stereotactic radiosurgery. Journal of Applied Clinical Medical Physics; 2011;12 (2); 133-145

 26.         Gopishankar N, Vivekanandhan S and Thulkar S. MAGAT gel dosimetry for its application in small field treatment techniques. Journal of Physics: Conferences Series; 2010; 250; 12061

 27.         Kannan L, Lodha R, Vivekanandhan S, Bagga A, Kabra SK and Kabra M. Intravenous fluid regimen and hyponatraemia among children: a randomized controlled trial. Pediatr Nephorolog; 2010; 25(11); 2303-2309

 28.     Suhail H,Vivekanandhan S, Singh S and Behari M. Serological and clinical features of patients with myasthenia gravis in north Indian population. The International Journal Neuroscience, 2010; 120 (2); 115-119

 29.     Suhail H, Soundararajan CC, Singh S, Vivekanandhan S and Behari M. Apo-E genotypes and Myasthenia Gravis. Neurology India; 2010; 58 (3); 443-445

 30.     Suhail H, Vivekanandhan S, Singh S and Behari M. Coexistent of MuSK and AChR antibodies in a myasthenia gravis patient. Neurology India; 2010;  58 (4); 668-669

 31.     Biswas A, Ranjan R, Meena A, Akhter MS, Yadav BK, Munisamy M, Vivekanandhan S , Behari M and Saxena R. Homocystine Levels, Polymorphisms and the Risk of Ischemic Stroke in Young Asian Indians.  Journal of Stroke and Cerebrovascular Diseases; 2009; 18(2); 103-110

 32.     Lodha R, Arun S, Vivekanandhan S, Kohli U and Kabra SK. Myocardial cell injury is common in children with septic shock. Acta Paediatr; 2009; 98 (3); 478-481

 33.     Sarthi M, Lodha R, Vivekanandhan S  and Arora  NK. Adrenal status in children with septic shock using low –dose stimulation test.  Pediatric Critical Care Medicine;2007; 8(1); 23-28

 34.     Khandelwal D, Bhatia M, Vivekanandhan S, Singh S, Shukla G, Goyal V and  Behari M. IgM anti GM1 antibody titers in patients with monomelic amyotrophy.  Neurology India; 2006; 54 (4 ); 399-401

 35.     Kailash U, Soundararajan CC, Lakshmy R, Arora R, Vivekanandhan S and Das BC. Telomerase activity as an adjunct to high – risk human papillomavirus types 16 and 18 and cytology screening in cervical cancer.  British Journal of Cancer; 2006; 95 (9); 1250 -1257

 36.     Lodha R, Vivekanandhan S, Sarathi M and Kabra SK. Serial circulating Vasopressin levels in children with septic shock.  Pediatr Crit Care Med, 2006; 7(3), 220-224

 38.     Soundararajan CC, Adhin A, Tripathi M, Prasad HK, Jain S and Vivekanandhan S. Association of CYP2D6 100 C > T and 2850 C > T polymorphisms with generalized tonic clonic seizures among Indians. Neural Transm; 2006; 113 (12); 1873-1876

Text Book publication:- 

text

Text Book publication:- 

Co - Author of the chapter:    “Digital filtering techniques to reduce image noise and improve dose resolution in X-Ray CT based normoxic gel dosimetry”

Book                                   :    “Radiation Therapy” (ISBN 979-953-307-341-4)

Research

RESEARCH LABORATORY 

·         BIOCHEMICAL AND MOLECULAR STUDIES

     Basic research techniques in biochemistry and molecular biology are used to explore various aspects of diseases in CNS. Following neurodegenerative diseases are the main focus of our research:-

ALZHEIMER’S DISEASE

CNS ISCHEMIA

EPILEPSY

SCHIZOPHRENIA

SPINOCEREBELLAR ATAXIA

WILSON DISEASE

MULTIPLE SCLEROSIS

PARKINSON’S DISEASE

BIPOLAR DISORDER

AMYOTRPIC LATERAL SCLEROSIS (ALS) 

·         DRUG/ PHARMACOGENETIC STUDIES

We explore the genetic involvement of neurodegenerative diseases and the metabolic effects of therapeutic drugs. Genetic polymorphisms of disease related genes and drug metabolizing enzymes  in Indian population  are of the main focus of our study 

·         CELL CULTURE STUDIES

We are working on Human cortical Neurons and HepG2 cell lines.  

FACILITIES IN THE NEUROBIOCHEMISTRY RESEARCH LABORATORY

 

FACILITY

MANUFACTURER

  1.  

BIOCHEMISTRY ANALYZER

BECKMANN COULTER

  1.  

CELL CULTURE FACILITY

 

  1.  

CELL CULTURE CO2 INCUBATOR

THERMO SCIENTIFIC

  1.  

CELL IMAGING- PHASE CONTRAST MICROSCOPE

NIKON

  1.  

CHEMILUMINESCENCE

SIEMENS

  1.  

COLD CENTRIFUGE

ALC- THERMO

  1.  

ELISA PLATE READER

TECAN, BIORAD

  1.  

GAMMA COUNTER-RIA

 

  1.  

GEL DOCUMENTATION SYSTEM

ALPHA INNOTECH

  1.  

GRADIENT PCR

EPPENDROF

  1.  

HPLC

WATERS

  1.  

ISOELECTRIC FOCUSING

SEBIA

  1.  

PCR- RFLP

APPLIED BIOSYSTEMS, BIORAD

  1.  

PROTEIN ELECTROPHORESIS UNITS

BANGLORE GENEI

  1.  

QUANTITATIVE RT PCR

BIORAD

  1.  

SSCP

 

  1.  

WESTERN BLOT FACILITY

BANGLORE GENEI

 

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