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अखिल भारतीय आयुर्विज्ञान संस्थान, नई दिल्ली
All India Institute Of Medical Sciences, New Delhi
कॉल सेंटर:  011-26589142

Dr. Subrata Sinha

NAME: SUBRATA SINHA

 

Email:

यह ईमेल पता spambots से संरक्षित किया जा रहा है. आप जावास्क्रिप्ट यह देखने के सक्षम होना चाहिए. यह ईमेल पता spambots से संरक्षित किया जा रहा है. आप जावास्क्रिप्ट यह देखने के सक्षम होना चाहिए.

                                               

EDUCATIONAL QUALIFICATIONS:

Degree

Year

Board/University

Remarks

PhD

 

 

MD

(Biochemistry)

 

MBBS

 

 Higher Secondary

1989

 

 

 1983

 

 

 1980

Council of National Academic Awards, UK at MRC Toxicology Unit, Carshalton, UK

 

All India Institute of Medical Sciences, New Delhi

 

 All India Institute of Medical Sciences, New Delhi

 

Central Board of Secondary Education, New Delhi

Title of Thesis: The role of oncogenes in experimental rat liver cancer

 

 Title of Thesis: Studies of plasma membrane specific antigen of thehuman placenta

 

 Sir Dorabjee Tata Award for the best undergraduate in Biochemistry

 

First Division, Distinction in Physics, Chemistry & Mathematics

 

 
DETAILS OF EMPLOYMENT

 

Institution

Position

Period of work

Department of Biochemistry, All India Institute of Medical Sciences, New Delhi

 

National Brain Research Centre(Autonomous institution of the Dept of Biotechnology) Manesar, Haryana

 

Additional charge Regional Centre of Biotechnology (another DBT institute)

 

Department of Biochemistry All India Institute of Medical Sciences, New Delhi

 

 

 

 

 

 

 

MRC Toxicology Unit, Carshalton, England [currently relocated to Leicester University(on leave from the Indian Councilof Medical Research)

 

India Council of Medical Research,

Talent Search Scheme  (posted at the National Institute of Immunology, New Delhi).

 

All India Institute of Medical Sciences, New Delhi

Professor and Head, resumed charge after deputation

 

 

Director

 

 

 Executive Director

  

 

Professor and Head

  

Additional Professor

 

Associate Professor

 

Assistant Professor

 

 

Smith and Nephew Fellow and Non-Clinical-Scientist-1A Also registered for PhD

 

 

 Research Officer

 

 

 

 Junior Resident (Biochemistry)(Enrolled for M.D.)

Since 29 Dec 2017

 

 

 on deputation from AIIMS 28 June 2010 to 28 Dec 2017

 

 

 Nov 2015- Oct 2016

 

 

December 1998 till 28thJuly, 2010 (Head of Dept. since 2003)

 

July 1996 to November 1998

 

July 1992 to July 1996

 

May 1988 to July 1992

 

 

May 1984 to December 1986

 

 

 January 1984 to till May 1988

on leave from May 1984 to December 1986

 

 

 January 1980 to December    

1983

  

AWARDS AND HONOURS

Fellowships of academies and other bodies

  1. Fellow of the Indian National Science Academy, 2006 (Sectional Committee for Medical Sciences 2008 -11, Convener , Health Sciences 2015 -18 ),  Vice President 2020-210)
  2. Fellow of the Indian Academy of Sciences, 2003 (member Sectional Committee for Medicine 2013, Convener of Committee 2015 -18)
  3. Indian Academy of Neurosciences 2011 (Dean of the Academy 2012-14, President, 2015-17)
  4. Fellow of the National Academy of Medical Sciences, 2007
  5. Fellow of National Academy of Sciences, 2005
  6. Member, Guha Research Conference, 2008

Selected Fellowships

  1. J  C Bose fellowship of the DST, 2016
  2. Awarded ICMR Senior Biomedical Fellowship, Indian Council of Medical Research for visit to CBER, FDA, USA, 2008
  3. Swarnajayanti fellowship of the Dept of Science and Technology (1998)
  4. Indian National Science Academy Exchange Fellowship for UK (1997)

Awards, Named Orations and Plenary Lectures

  1. Sun Pharma Award Medical Sciences – Basic research, for 2015
  2. Awarded the Vishwanath Memorial Lecture Award of the Indian National Science Academy 2015
  3. Awarded the V S Khanolkar Memorial Lecture of the National Academy of Medical Sciences for 2014
  4. Awarded the D N Prasad Memorial Lecture of the National Institute of Mental Health and Neurosciences, Bangalore, 2012
  5. Awarded the Seth G. S. Medical College & KEM Hospital Oration Award of the Association of Clinical Biochemists of India, 2013
  6. Chief Guest and Inaugural Lecturer for National Symposium on the theme “Neurosciences and Its Future Prospects” by Interdisciplinary Brain Research Centre(IBRC), Faculty of Medicine, Aligarh Muslim University, 2014.
  7. Inaugural Lecture, 2nd International Conference on Perspectives of Cell Signaling and Molecular Medicine, to 11 January, 2012, Bose Institure, Kolkata
  8. Inaugural Lecture, Brain Storming Meeting on Translational Research in Neuroscience, Sept 16-17,2011, Banaras Hindu University, Varanasi
  9. Chief Guest and Speaker, National Science Day celebrations, University of Hyderabad, 2006
  10. Awarded the Kodalivimad Oration of the Association of Medical Biochemists of India (2000).

   

PUBLICATIONS (Last 5 years)

Tumour Biology and genetics (last author as corresponding author unless otherwise indicated)

        1. Prajapati B, Fatma M, Fatima M, Khan MT, Sinha S and Seth PK Identification of lncRNAs Associated With Neuroblastoma in Cross-Sectional Databases: Potential Biomarkers. Front. Mol. Neurosci. (2019) 12:293. doi:         10.3389/fnmol.2019.00293 Joint corresponding author

 

        2. Prajapati B, Fatma M, Maddhesiya P, Sodhi MK, Fatima M, Dargar T, Bhagat R, Seth P,Sinha S.Identification and epigenetic analysis of divergent long non-coding RNAs in multilineage differentiation of human Neural Progenitor Cells.RNA Biol. 2019 Jan;16(1):13-24. doi: 10.1080/15476286.2018.1553482. Epub 2018 Dec 27

 

        3. Devasenapathy S, Midha R, Naskar T, Mehta A, Prajapati B, Ummekulsum M, Sagar R, Singh NC, Sinha S. A pilot Indian family-based association study between dyslexia and Reelin pathway genes, DCDC2 and ROBO1, identifies modest association with a triallelic unit TAT in the gene RELN Asian J Psychiatr. 2018 Aug 25;37:121-129. doi: 10.1016/j.ajp.2018.08.020. [Epub ahead of print] PMID: 30199849

 

        4.Jalota A, Kumar M, Das BC, Yadav AK, Chosdol K, Sinha S. A drug combination targeting hypoxia induced chemoresistance and stemness in glioma cells. Oncotarget. 2018 Apr 6;9(26):18351-18366. doi: 10.18632/oncotarget.24839. eCollection 2018 Apr 6. PMID: 29719610

 

        5. Srivastava C, Irshad K, Dikshit B, Chattopadhyay P, Sarkar C, Gupta  D K,  Sinha S, Chosdol K. FAT1 modulates EMT and stemness genes expression in hypoxic glioblastoma.Int J Cancer. 2018 Feb 15;142(4):805-812. doi: 10.1002/ijc.31092. Epub 2017 Oct 17. PMID:28994107

 

        6. Naskar T, Faruq M, Banerjee P, Khan M, Midha R, Kumari R, Devasenapathy S, Prajapati B, Sengupta S, Jain D, Mukerji M, Singh NC, Sinha S.Ancestral Variations of the PCDHG Gene Cluster Predispose to Dyslexia in a Multiplex Family. EBioMedicine. 2018 Feb;28:168-179. doi: 10.1016/j.ebiom.2017.12.031. Epub 2018 Jan 9.PMID: 29409727

 

        7.  Madan E, Dikshit B, Gowda SH, Srivastava C, Sarkar C, Chattopadhyay P, Sinha S, Chosdol K. FAT1 is a novel upstream regulator of HIF1α and invasion of high grade glioma. Int J Cancer. 2016 Dec 1;139(11):2570-82. doi: 10.1002/ijc.30386. Epub 2016 Aug 29Joint corresponding author

 

        8.   Jalota A, Kumar M, Das BC, Yadav AK, Chosdol K, Sinha S.Synergistic increase in efficacy of a combination of 2-deoxy-D-glucose and cisplatin in normoxia and hypoxia: switch from autophagy to apoptosis. Tumour Biol. 2016 Jun 15 doi:    10.1007/s13277-016-5089-8

 

        9.    Bhagat M, Palanichamy JK, RamalingamP,Mudassir M, Irshad K, Chosdol K, Sarkar C,  SethP,Goswami S, Sinha S, Chattopadhyay P. HIF-2 mediates a marked increase in migration and stemnesscharacteristics in a subset of glioma cells under hypoxia by activatingan Oct-4/Sox-2-Mena (INV) axis. The International Journal of Biochemistry & Cell Biology 74 (2016) 60–71.

 

        10.  Kumar M, Mani P, Pratheesh P, Chandra S, Jeyakkodi M, Chattopadhyay P, Sarkar DP, Dagger and Sinha S Membrane fusion mediated targeted cytosolic drug delivery through scFv engineered Sendai viral envelopes Current Molecular Medicine 2015 15 386 – 400.

 

        11.  Khan I, Zakaria MK, Kumar M, Mani P, Chattopadhyay P, Sarkar DP, SinhaS. Erratum to: A novel placental like alkaline phosphatase promoter driven transcriptional silencing combined with single chain variable fragment antibody based virosomal delivery for neoplastic cell targeting.  J Transl Med. 2015 Sep 14;13:300. doi: 10.1186/s12967-015-0643-5. No abstract available PMID:  26370128.

 

        12.  Kumar M, Khan I, Sinha S. Nature of immobilization surface affects antibody specificity to placental alkaline phosphatase. J Immunoassay Immunochem. 2015;36(4):405-13. doi: 10.1080/15321819.2014.973117 PMID: 25321174

 

        13.  Kassab MA, Mudassir M, Singh A, N M, Bhagat M, Palanichamy JK, Ramalingam P, Chosdol K, Sinha S, Chattopadhyay P. Gene Silencing and Activation of Human Papillomavirus 18 Is Modulated by Sense Promoter Associated RNA in Bidirectionally Transcribed Long Control Region.PLoS One. 2015 Jun 5;10(6)

 

        14. Irshad K, Mohapatra S.K., Srivastava C, Garg H, Mishra S, Dikshit B, Sarkar C,  Gupta D, Sarat PC, Chattopadhyay P, Sinha S*;Chosdol K.  A combined gene signature of hypoxia and Notch pathway in human glioblastoma and its prognostic relevance". PLOS One 2015 March 3 DOI:10.1371/journal.pone.0118201. eCollection 2015.PMID:25734817.Joint corresponding author

 

        15.  Shahi MH, Zazpe I, Afzal M, Sinha S, Rebhun RB, Meléndez B, Rey JA, CastresanaJS.Epigenetic regulation of human hedgehog interacting protein in glioma cell lines and primary tumorsamples.Tumour Biol. 2015 Apr;36(4):2383-91. doi: 10.1007/s13277-014-2846-4. Epub 2014 Nov 22.

 

        16.  Zakaria M, Khan I, Mani P, Chattopadhyay P, Sarkar DP, Sinha S. Combination of hepatocyte specific delivery and transformation dependent expression of shRNA inducing transcriptional gene silencing of c-Myc promoter in hepatocellular carcinoma cells. BMC Cancer 2014, 14:582 (10 August 2014)

 

        17. Ramalingam P, Palanichamy JK, Singh A, Das P, Bhagat M, Kassab MA, Sinha S, Chattopadhyay P.Biogenesis of intronic miRNAs located in clusters by independent transcription and alternative splicing.  RNA. 2014 Jan; 20(1):76-87. doi: 10.1261/rna.041814.113. Epub 2013 Nov 13.

 

        18.  Dikshit B, Irshad K, Madan E, Aggarwal N, Sarkar C, Chandra PS, Gupta DK, Chattopadhyay P, Sinha S, Chosdol K. FAT1 acts as an upstream regulator of oncogenic and inflammatory pathways, via PDCD4, in glioma cells.Oncogene. 2013 Aug 15;32(33):3798-808. Joint corresponding author

 

IMMUNOLOGY AND INFECTIOUS DISEASE BIOLOGY

 

        19. Isolation and Characterization of Cross-Neutralizing Human Anti-V3 Single-Chain Variable Fragments (scFvs) Against HIV-1 from an Antigen Preselected Phage Library. Kumar R, Kumari R, Khan L, Sankhyan A, Parray HA, Tiwari A, Wig N, Sinha S, Luthra K. ApplBiochemBiotechnol. 2018 Aug 28. doi: 10.1007/s12010-018-2862-8. [Epub ahead of print] PMID: 30151637

 

        20.  Kumar S, Kumar R, Khan L, Makhdoomi MA, Thiruvengadam R, Mohata M, Agarwal M, Lodha R, Kabra SK, Sinha S, Luthra K.CD4-Binding Site Directed Cross-Neutralizing scFvMonoclonals from HIV-1 Subtype C Infected Indian Children.Front Immunol. 2017 Nov 15;8:1568. doi: 10.3389/fimmu.2017.01568. e Collection 2017. PMID; 2918785

 

        21. Khan L, Kumar R, Thiruvengadam R, Parray HA, Makhdoomi MA, Kumar S, Aggarwal H, Mohata M, Hussain AW, Das R, Varadarajan R, Bhattacharya J, Vajpayee M, Murugavel KG, Solomon S, Sinha S, Luthra K. Cross-neutralizing anti-HIV-1 human single chain variable fragments(scFvs) against CD4 binding site and N332 glycan identified from a recombinant phage library. Sci Rep. 2017 Mar 23;7:45163. doi: 10.1038/srep45163

 

        22. Sankhyan A, Sharma C, Dutta D, Sharma T, Chosdol K, Wakita T, Watashi W, Awasthi A, Acharya SK, Khanna N, Tiwari A and Sinha S.  Inhibition of preS1-hepatocyte interaction by an array of recombinant human antibodies from naturally recovered individuals. Scientific Reports 2016 6: 21240 doi: 10.1038/srep21240.

 

        23. Kumar R, Basu A, Sinha S, Das M, Tripathi P, Jain A, Kumar C, Atam V, Khan S and Singh AS. Role of oral minocycline in acute encephalitis syndrome in India – a randomized controlled trial. BMC Infectious Diseases 2016 doi:10.1186/s12879-016-1385-6.

 

        24.Kulshreshtha P, Tiwari A, Priyanka, Joon S, Sinha S, Bhatnagar R. Investigation of a panel of monoclonal antibodies and polyclonal sera against anthrax toxins resulted in identification of an anti-lethal factor antibody with disease-enhancing characteristics.MolImmunol. 2015 Sep 9. pii: S0161-5890(15)30027-4. doi: 10.1016/j.molimm.2015.07.019.

 

        25. Singh A, Palanichamy JK, Ramalingam P, Kassab MA, Bhagat M, Andrabi R, Luthra K, Sinha S, Chattopadhyay P.  Long-term suppression of HIV-1C virus production in human peripheral blood mononuclear cells by LTR heterochromatization with a short double-stranded RNA. J AntimicrobChemother. 2014 Feb;69(2):404-15. doi: 10.1093/jac/dkt348. Epub 2013 Sep 10

 

        26.  Kumar R, Andrabi R, Tiwari A, Sankaran S. P, Wig N, Dutta D, Sankhyan A, Khan L, Sinha S, Luthra K. A novel strategy for efficient production of anti-V3 human scFvs against HIV-1 clade C, BMC Biotechnology Online Publication, 15 November 2012; doi:10.1186/1472-6750-12-87 (joint corresponding author)

 

PATENTS

1.   A recombinant mouse-human Chimaeric Fab against Hepatitis B surface antigen. B Bose, Navin Khanna, S K Acharya and S Sinha ( PCT filed, national phase granted in South Africa No 2009/04338 on 26 May 2010, Indian Patent No 251904  (2704/DEL/2006) Dated 18/12/2006, granted on 16/04/2012 and others are in progress).- Jointly by Dept. of Biotechnology, AIIMS and ICGEB. Indian Patent Granted on    

2.   A humanized high Affinity Recombinant antibody against Hepatitis B surface antigen. A Tiwari, Navin Khanna, S K Acharya and S Sinha. For India: Publication number: IN2008DE190, Filing Date:Jan 23, 2008, Original published format:IN DE01902008; International Application No: PCT/IN2008/000796, International Filing Date: Dec 2, 20086: Publication number: US 2011/0046354 A1 . Filing date: Dec 2, 2008, Current U.S. Classification: 530/387.3; US Patent granted For Europe:Publication number: EP2250198 A1, Publication date: Nov 17, 2011; Filing Date:Dec 2, 2008, European Classification: C07K 16/08A12 Jointly by Dept. of Biotechnology, AIIMS and ICGEB

3.   A novel small interfering RNA (siRNA) targeting the Human Papilloma Virus – 16 enhancer region leading to down regulation of the expression of viral oncogenic mRNA’s E6 & E7 in a human Papilloma Virus – 16 (HPV-16) positive cervical carcinoma cell line, and its novel genomic target. (Patent No. 263597 dt 5/11/14; Indian Patent Application No. 2746/Del/2008 dt. 4/12/2008, DBT and AIIMS) J Palanichamy, S Sinha, P Chattopadhyay.

4.   A novel small interfering RNA (siRNA) directed against ME lal binding region in the P2 promoter of proto-oncogene c-myc results in its transcriptional gene silencing. M Mehndiratta, S. Sinha. P Chattopadhyay. (Patent No, 263225 dt 15/10/14; Indian Patent Application No, 2747/Del/2008 dt 4/12/2008, DBT and AIIMS).”

5.   Use of the FAT1 gene and its products, including RNA, protein and the derivatives of the same, as suitable molecule/s for either inflammation or cancer and the associated phenotype and the processes linking the same and also as a biomarker for the above processes. K Chosdol, B Dikshit and S Sinha (Indian patent filed, 45/DEL/2012PCT filed on 5 Jan 2012, PCT/IB2013/050086, filed on 4 Jan 2013).(Jointly by DBT, AIIMS and NBRC). US Patent granted 2017

6.   Placental Like Alkaline Phosphatase (PLAP) Promoter Mediated Cell Targeting S Sinha, I Khan, K Ahmad, K Chosdol and P Chattopadhyay. (Provisional Indian Patent No 1400/DEL/2013. Filed on 10 May, 2013, PCT/IB2014/061350 dated May 10, 2014, US Patent Granted - Application No.: 14/722,361 filed on September 03, 2015 (jointly by DBT, AIIMS and NBRC). US Patent granted, 2018

 

Dr. Siddhartha Kundu

Contact details

 

Address:

Email:
Telephone:
Public profiles:

Research focus:
Areas of Interest

Room No. 3027B, Department of Biochemistry,
AIIMS, Ansari Nagar, New Delhi – 110029
यह ईमेल पता spambots से संरक्षित किया जा रहा है. आप जावास्क्रिप्ट यह देखने के सक्षम होना चाहिए.
+91-11-26596514; +91-9818054915
https://orcid.org/0000-0003-3962-776X
https://loop.frontiersin.org/people/174292/overview
Mathematical and Computational Biochemistry
Mathematical models of macromolecules and complex biochemical systems

Mathematical and Theoretical Bioinformatics
Theoretical Biophysics
Biologically relevant big data analytics

Educational qualifications

Degree

Subject

University/Institution

Year

PhD

Computational Biology & Bioinformatics

School of Computational and Integrative Sciences (SCIS),

Jawaharlal Nehru University,New Mehrauli Road, New Delhi 110067

2014-2018

MD

Biochemistry

All India Institute of Medical Sciences (AIIMS),

Ansari Nagar, New Delhi 110029

1999-2001

MBBS

Pre-&Para-/Medical/ Surgical subjects

University College of Medical Sciences (UCMS),

Dilshad Garden, New Delhi 110095

1992-1996

Memberships

1.

Society for Mathematical Biology (SMB)

 

2.

European Society for Mathematical and Theoretical Biology (ESMTB)

 

3.

Biophysical Society (BPS)

 

Research publications (complete citations)

2019

  1. Kundu S#*. Insights into the mechanism(s) of digestion of crystalline cellulose by plant class C GH9 endoglucanases. J Mol Model. 2019 Jul 23;25(8):240. doi:10.1007/s00894-019-4133-1. PubMed PMID: 31338614.

2018

  1. Kundu S#*. Mathematical basis of predicting dominant function in protein sequences by a generic HMM-ANN algorithm. ActaBiotheor. 2018 Jun;66(2):135-148. doi: 10.1007/s10441-018-9327-x. Epub 2018 Apr 26. PubMed PMID: 29700659
  2. Kundu S*, Sharma R*. Origin, evolution, and divergence of plant class C GH9 endoglucanases. BMC Evol. Biol. 2018 May 30;18(1):79. doi:10.1186/s12862-018-1185-2. PubMed PMID: 29848310; PubMed Central PMCID:PMC5977491

2017

  1. Kundu S#*. Mathematical basis of improved protein subfamily classification by a HMM-based sequence filter. Math Biosci. 2017 Nov;293:75-80. doi:10.1016/j.mbs.2017.09.001. Epub 2017 Sep 13. PubMed PMID: 28916136

2016

  1. Kundu S*, Sharma R*. In silico Identification and Taxonomic Distribution of Plant Class C GH9 Endoglucanases. Front Plant Sci. 2016 Aug 12;7:1185. doi:10.3389/fpls.2016.01185. eCollection 2016. PMID: 27570528; PMCID: PMC4981690.
  2. Kundu S#*. Stochastic modelling suggests that an elevated superoxide anion-hydrogen peroxide ratio can drive extravascular phagocyte transmigration by lamellipodium formation. J Theor Biol. 2016 Oct 21;407:143-54. doi:10.1016/j.jtbi.2016.07.002. Epub 2016 Jul 2. PubMed PMID: 27380944.

2015

  1. Kundu S#*. Co-operative intermolecular kinetics of 2-oxoglutarate dependent dioxygenases may be essential for system-level regulation of plant cell physiology. Front Plant Sci. 2015 Jul 15;6:489. doi: 10.3389/fpls.2015.00489. eCollection 2015. PMID: 26236316; PMCID: PMC4502536.
  2. Kundu S#*. Unity in diversity, a systems approach to regulating plant cellphysiology by 2-oxoglutarate-dependent dioxygenases. Front Plant Sci. 2015 Mar 11;6:98. doi: 10.3389/fpls.2015.00098. eCollection 2015. PMID: 25814993; PMCID: PMC4356072.

2012

  1. Kundu S#*. Distribution and prediction of catalytic domains in 2-oxoglutarate dependent dioxygenases. BMC Res Notes. 2012 Aug 4;5:410. doi:10.1186/1756-0500-5-410. PMID: 22862831; PMCID: PMC3475032.

2011

  1. Kundu S*, Subodh S. Gradient sensing in vectorialchemotaxis – a novel role for Reactive Oxygen Species. International Journal of Trends in Medicine. 2011 1; 54-59.

2002

  1. Singh N, Khanna N, Sharma H, Kundu S, Azmi S. Insights into the molecular mechanism of apoptosis induced by TNF-alpha in mouse epidermal JB6-derived RT-101cells. BiochemBiophys Res Commun. 2002 Jul 5;295(1):24-30. PMID:12083761
 

(#) Single author; (*)Corresponding author

Positions held

Position

Subject/Work

University/Institution

Year

Assistant Professor

Biochemistry

All India Institute of Medical Sciences (AIIMS),
Ansari Nagar, New Delhi 110029

10/2019 -

Associate Professor

Biochemistry

Army College of Medical Sciences (ACMS),
Brar Square, Delhi Cantt., New Delhi – 110010

2015-2018

Dr. Baba SahebAmbedkar Medical College and Hospital (BSAMCH), Govt. of NCT of Delhi, Rohini, Delhi 110085 2018-2019

Assistant Professor

Biochemistry

Army College of Medical Sciences (ACMS),
Brar Square, Delhi Cantt.,New Delhi – 110010

2009-2014

Scientist ‘D’ (Medical)

Program Officer

Indian Council of Medical Research (ICMR),
V. RamalingaswamiBhawan,

Ansari Nagar, New Delhi 110029

07-10/2019

Senior Level Consultant

Program Director

Information Technology Research Academy (ITRA),
Digital India Corporation (formerly Media Lab Asia),
Ministry of Electronics and Information Technology,

C-DOT campus, New Delhi 110030
2016-2017

Research Consultant

Computational Biology

India Research Labs (IRL) IBM 2002-2003

Research Associate/Fellow/Scientist

PostDoctoral work

International Center for Genetic Engineering and Biotechnology (ICGEB)

05-10/2014

National Institute of Immunology (NII) 2005-2008
ICMR-National Institute of Pathology (NIOP) 2003-2004
Indian Institute of Technology Delhi (IITD) 01-05/2002

Dr.Riyaz Ahmad Mir

Name of Faculty Member: Dr.Riyaz Ahmad Mir

Designation: Assistant Professor

Address: 3rd floor Dept. of Biochemistry(Room no 3027-B)

Official Phone:01126546514

Email id: यह ईमेल पता spambots से संरक्षित किया जा रहा है. आप जावास्क्रिप्ट यह देखने के सक्षम होना चाहिए.

Academic Details

Degree

Subject

University/ Institution

Year

B.Sc.

Zoology, Botany, Chemistry, English

University of Kashmir

Hazratbal Srinagar

2002

M.Sc.

Biochemistry

University of Kashmir

Hazratbal Srinagar

2004

Ph.D

Biochemistry

AIIMS New Delhi

2011

 

Positions held:

 

Position

Department

University/ Institution

Dates

Postdoc Research Associate

Genetics Cell Biology and Anatomy

University Of Nebraska Medical Center Omaha NE,USA

2011-2014

Senior Research Associate

Genetics Cell Biology and Anatomy

University Of Nebraska Medical Center Omaha NE,USA

2014-2016

Assistant Professor

Biochemistry

AIIMS New Delhi

Nov2016—present

 

Awards and Society Memberships

Carl Storm international Diversity Fellowship (2009).

Research Focus of the Lab

The research focus of my lab is to understand how molecular chaperones regulate cell cycle , and how this machinery is disrupted during cancer. Another area of my research is how oncoproteins disrupt chaperone function.

Positions Available

Candidates with their own fellowship are welcome to join my lab

Key publications

  1. MohdSaleem Dar, Paramjeet Singh, Riyaz A. Mir,Mohd Jamal Dar.(2017) “Βeta­cateninN­terminaldomain:An enigmatic region prone to cancer causing mutations” Mutation Research Reviews in Mutation Research 773 : 122-33.
  2. Olou AA, Sarkar A, Bele A, Gurumurthy CB, Mir RA, Ammons SA, Mirza S, Saleem I, Urano F, Band H, Band V.(2017) “Mammalian ECD protein is a novel negative regulator of the PERK arm of unfolded protein response.”Mol Cell Biol Epubahead of print.
  3. Riyaz A. Mir, Jeff Lovelace, Nicholas P. Schafer, Peter D. Simone, AdmirKellezi, Carol Kolar, GaelleSpagnol,Paul L. Sorgen, Hamid Band, Vimla Bandand Gloria  E.O.Borgstahl. (2016) “Biophysical characterization and modeling of human Ecdysoneless (ECD) protein supports a scaffolding function.” AIMS BIOPHYSICS 3 (1): 146-162
  4. Mir RA, Bele A, Mirza S, Srivastava S, Olou A, Ammons SA, Kim JH, Gurumurthy CB, Qiu F, Band H, Band V. (2015) “A novel interaction of ECD protein with R2TP complexcomponent RUVBL1 is required for the functional role of ECD in cell cycle progression”.Mol Cell Biol.36(6):886-99.
  5. 5.      Belle A, Mirza S, Zhang Y, Ahmad Mir R, Lin S, Kim JH, Gurumurthy CB, West W, Qiu F, Band H, Band V. (2015)“The cell cycle regulator ecdysoneless cooperates with H-Ras to promote oncogenic transformation of human mammary epithelial cells”.Cell Cycle.14(7)990-1000
  6. 6.      Chaturvedi NK, Mir RA, Band V, Joshi SS, Guda C (2014)“Experimental validation of predicted subcellular localizations of human proteins”. BMC Res Notes 7:992-997
  7. Romsha Kumar, VishwasTripathi, Syed M Andrabi, NeeraNath, Riyaz A Mir, Shyam S Chauhan, KalpanaLuthra.CXCR7 mediated Giα independent activation of ERK and Akt promotes cell survival and chemotaxis in T cells. (Cell Immunol.  2012; 272(2): 230-41)
  8. Riyaz A Mir, Shyam.S Chauhan.Down regulation of a matrix degrading cysteine protease cathepsin L, by acetaldehyde: role of C/EBPα (PloS One2011; 6(6): e20768).
  9. Shivani Mittal, Riyaz A Mir, and Shyam S. Chauhan. Upregulation of human cathepsin L expression by transcriptional regulatory mechanism. (Biol. Chem.2011; 392(5):405-13).
  10. Riyaz A Mir*, R Katara *, A AShukla, N Singh,Shyam.SChauhan.Wild   Type p53-Dependent Transcriptional up Regulation of Cathepsin L Expression is mediated by C/EBPα in Human Glioblastoma Cells. (Biol Chem. 2010; 391(9):1031-40) * Equal authorship.

 

Dr. Pramod Kumar Gautam

New Page 4

Name of Faculty Member: Dr. Pramod Kumar Gautam

Designation: Assistant Professor

Address: Room No 3027-B, Teaching block, Department of Biochemistry, 
                All India Institute of Medical Sciences, Ansari Nagar, New Delhi-110029

Official Phone: 011-26546514

Email id: यह ईमेल पता spambots से संरक्षित किया जा रहा है. आप जावास्क्रिप्ट यह देखने के सक्षम होना चाहिए. ; यह ईमेल पता spambots से संरक्षित किया जा रहा है. आप जावास्क्रिप्ट यह देखने के सक्षम होना चाहिए.

Skype id -Pramod_kumar_gautam

https://www.researchgate.net/profile/Pramod_Gautam3

Short Biography

Academic Details

Degree

Subject

University/ Institution

Year

B.Sc.

Chemistry, Botany, Zoology

D. D. U. Gorakhpur University, Gorakhpur

2004

M.Sc.

Biochemistry

V.B.S.PU. Jaunpur

2006

Ph.D.

Biochemistry

Banaras Hindu University

2014

 

 

Positions held:

Position

Department

University/ Institution

Dates

Assistant Professor

Biochemistry

AIIMS, New Delhi

December2016-present

Post Doc Fellow

Biochemistry

Banaras Hindu University, Varanasi

2014-2016

 

GRANTS AND FELLOWSHIPS:

  • 2016-DST Research Grant (ongoing)

Award/Honors

  • Best Poster Presentation Awarded, International Symposium on Cancer Biology, Nov 14-16, 2011, National Institute of Immunology, New Delhi, India.
  •  DST Inspire Faculty award in the year 2016

 

Membership of Society

  • Life Member of The Science Advisory Board
  • Life member of the Indian Immunology Society
  • Member of the International Society of Exercise and Immunology
  •  Member of the American Academy of Allergy, Asthma & Immunology (AAAI).
  • Member of the Clinical Immunological Society.

o   Life Member of Cancer Immunotherapy (CIMT), Germany

    Editorial Board Membership

  • RED FLOWER PUBLICATION Ltd In the 2016
  • Member of Editorial Board of IRA publication form 2016

 

Research Focus of the Lab

  • Modulating and targeting HSP70 in lymphoma
  • Implication of Nanoparticles-Peptide Complex in Cancer Therapy
    • Targeting Stem cell for immunotherapy
    • Developing HSP based diagnostic Kit for Pre-stage of diagnosis of diseases.
    • Targeting cell  based ( Mɸ/DCs/NK cell/Treg)  immunotherapy

 

Positions Available

We are seeking applications from motivated, goal-oriented individuals with excellent academic background and having their own fellowships. Candidates with experience in Immunology/ Cancer Biology/Immunotherapy/ Drug delivery are encouraged to contact and send their CV along with a cover letter at  यह ईमेल पता spambots से संरक्षित किया जा रहा है. आप जावास्क्रिप्ट यह देखने के सक्षम होना चाहिए.

 Key publications

  1. Gautam PK, Deepak P, Kumar S, Acharya A. Role of macrophage in tumor microenvironment: prospect in cancer immunotherapy. Euro. J. Inflammation. (2013) 10(1): 1-14.
  2. Gautam PK, Maurya BN, Kumar S, Deepak P, Kumar S Jr, Tomar MS, Acharya A Progressive growth of a murine T cell lymphoma alters population kinetics and cell viability of macrophages in a tumor-bearing host. Tumor Biol.  (2013). 34:827–836.
  3. Kumar S, Deepak P, Kumar S, Gautam PK, Acharya A.  A benzophenanthridine alkaloid, chelerythrine induces apoptosis in vitro in a Dalton’s Lymphoma.. J Cancer Res Ther. (2013) 9(4):693-700.
  4. P. K. Gautam & Arbind Acharya. Morphological effects of autologous hsp70 on peritoneal macrophages in a murine T cell lymphoma. Tumor Biol., (2013). 34:3407–3415.
  5. Pramod K. Gautam & Arbind Acharya Suppressed expression of homotypic multinucleation, extracellular domains of CD172α (SIRP-α) and CD47 (IAP) receptor in TAMs up-regulated by Hsp70-peptide complex in Dalton’s lymphoma.. Scan J Immunol.,(2014). 80; 22-35.
  6. Pramod Kumar Gautam & Arbind Acharya. Antigenic Hsp70–peptide upregulate altered cell surface MHC class I expression in TAMs and increases anti-tumor function in Dalton’s lymphoma bearing mice.  Tumor Biol., (2015). 36:2023–2032.
  7. Pramod K. Gautam & Arbind Acharya Antigenic Hsp70-peptide upregulate altered suppressed expression of docking receptor ICAM-1 in TAMs increases in Dalton's lymphoma bearing mice.. IJRST., (2015)., 5(III) :86-105.
  8. Pramod K. Gautam & Arbind Acharya Suppressed expression of CD80 (b7.1) and CD86 (b7.2) receptors in tams up-regulated by autologous hsp70– peptide complex in dalton’s lymphoma bearing balb/c mice IJRST., (2015)., 5(III):106-127.
  9. Pramod Kumar Gautam, Sanjay Kumar, Arbind Acharya. Non-mammalian Animals as Experimental Models for Modern Scientific Research. IJAREAS. (2015). 67-76.
  10. Sanjay Kumar, Pramod Kumar Gautam, Munendra Singh Tomar, Arbind Acharya. CD28 mediated T cell responses is upregulated by exogenous application of autologous hsp70-peptide complex intumor bearing mice. Immunol Res (2016) 64:313–323.

Ongoing projects:

  1. Role of Macrophage in the regulation of Bone and Blood forming stem cell and progenitor cells migration and development” (DST Funded)2017-07-31

Dr. Rakhee Yadav

Name of Faculty Member: Dr. Rakhee Yadav

Designation: Assistant Professor

Address: Room No. 3027B, Department of Biochemistry, Third Floor, Main Teaching Block, AIIMS, New Delhi-110029

Official Phone: 011-26546514

Email id: यह ईमेल पता spambots से संरक्षित किया जा रहा है. आप जावास्क्रिप्ट यह देखने के सक्षम होना चाहिए.

Short Biography (use template provided)

Academic Details

Degree

Subject

University/ Institution

Year

MBBS

 

Pt. BD Sharma PGIMS, MD University, Rohtak, Haryana

1998-2003

MD

Biochemistry

PGIMS, Rohtak, Pt BD Sharma University of Health Sciences, Rohatk, Haryana

2008-2011

 

Positions held

 

Position

Department

University/ Institution

Dates

Senior Resident

Biochemistry

VMMC and Safdarjung Hospital, New Delhi

08/08/2011- 12/01/2014

Assistant Professor

Biochemistry

SGT Medical College and Hospital; SGT University, Gurgaon (Haryana)

16/01/2014- 09/11/2016

Assistant Professor

Biochemistry

AIIMS, New Delhi

21/11/2016 onwards

 

Notable Awards and Society Memberships

  • Permanent member of AMBI (Association of Medical biochemists of India)
  • Life member of the International Forum of Teachers (IFT) of the UNESCO Chair in Bioethics (Haifa).
  • Trained on Medical Laboratories Quality Management System and Internal Audit as per ISO:15189 at National Institute of Training for Standardization, Bureau of Indian Standards.

Research Focus of the Lab

Presently the area of my interest is to elucidate the underlying cellular mechanisms contributing towards the chronic inflammatory state via the activation of an array of overlapping metabolic and inflammatory cross-talks in the adipose tissue of the obese individuals.

Obesity is a major problem worldwide that increases the risk for a wide range of diseases like diabetes and cardiovascular diseases. The reason why obesity is so closely associated with inflammation and insulin resistance is not completely understood.

An increased Endoplasmic Reticulum (ER) stress in obese individuals may be one of the underlying causes of the inflammatory state and insulin resistance in this metabolically dynamic and complex tissue. So, my current projects cater towards exploring the role of ER stress in obesity induced adipose tissue dysfunction and inflammation

Positions Available (Add a note if you are interested in taking JRF/SRF/Research trainees/MBBS summer fellows)

Applications from motivated, goal-oriented individuals with excellent academic background and experience in molecular biology and immunology having their own fellowships are welcome.

Key publications

  1. Bansal SK, Yadav R. A study of the extended lipid profile including Oxidized LDL, Small dense LDL, Lipoprotein (a) and Apolipoproteinsin the assessment of cardiovascular risk in hypothyroid patients. Journal of Clinical and Diagnostic Research 2016; 10(6): BC04-BC08.
  2. Yadav R, Bansal SK, Karunanand B, Pasha EH, Kumar B, Shastry SP. Association of Thyroid Disorders with the Hormones of Anterior Pituitary in Female Infertility. Annals of Pathology and Laboratory Medicine 2016; 3(4): A340-A346.
  3. Bansal SK, Yadav R, Tanwar R, Chitkara A, Khurana N. Non-Conventional Lipid Parameters for the Assessment of Cardiovascular Risk in Type 2 Diabetes Mellitus Patients in North India. Indian Journal of Health Sciences and Care 2016; 3(2): 49-54.
  4. Ghalaut VS, Yadav R, Dahiya K, Abrol P, Ghalaut PS, Dhankhar R. Levels Of Homocysteine, Folic Acid And Vitamin B12In Patients With Paediatric Acute Lymphoblastic Leukaemia. Australasian Medical Journal 2012; 5(4): 245-246.
  5. Yadav R, Verma SK, Bhartiya JP, Nandkeoliar MK. Changing Trends In Diagnostic Criteria Of Diabetes Mellitus: An Overview. Int  J Pharma Bio Sci 2013 Apr;4(2): 434-444.
  6. Yadav R, Verma SK, Bhartiya JP, Nandkeoliar MK. The Evaluation OfSerum Amylase In The Patients Of Type 2 Diabetes Mellitus, With A Possible Correlation With The Pancreatic Functions. J Clin Diagnostic Res. 2013;7(7):1291-1294.
  7. Yadav R, Bansal SK, Karunanand B, Yadav BK, Arora J. A Comparative Study of Methods of Estimation of LDL-Cholesterol: Direct vs Friedewald’s Formula and Their Impact on Risk Assessment for Coronary Artery Diseases. Indian Journal of Health Sciences and Care 2015;2(1):30-5.
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