Dr. Krishna Kumar Inampudi
Dr. Pradeep Sharma
Designation |
Assistant Professor |
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Contact Number |
+91-11-26594608 |
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Research Interests |
Structural Biology ; Rational Structure based Drug Design ; Multidrug Resistant Bacterial Therapeutics |
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Awards and Honors
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INSA Young Scientist Award |
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DST Inspire Faculty Award |
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S V Talekar Medal for the best postgraduate of Department of Biophysics (AIIMS) |
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Ludo Frevel Crystallography Award, ICDD, USA |
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Summer Training Award at ESRF, Grenoble, France (European Commission) |
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Chaired, Society of Young Scientists, AIIMS, New Delhi (2009-10) |
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IUCr Travel award to attend IUCr meeting at Osaka, Japan |
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Awarded CSIR-Junior Research Fellowship |
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Awarded CSIR Senior Research Fellowship |
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Gold Medalist from Maharshi Dayanand University, Rohtak |
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Merit certificate awarded by Higher Education Department Haryana |
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National Merit Scholarship |
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Significant Publications
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Gupta A, Singh PK, Sharma P, Kaur P, Sharma S, Singh TP (2019) Structural and biochemical studies of phosphopantetheine adenylyltransferase from Acinetobacter baumannii with dephospho-coenzyme A and coenzyme A. Int J Biol Macromol. 8130: 35145-35151. |
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Gupta A, Singh PK, Iqbal N, Sharma P, Baraigya HR, Kaur P, Umar MS, Ahmad F, Sharma A, Owais M, Sharma S, Singh TP (2019) Structural and binding studies of phosphopantetheine adenylyl transferase from Acinetobacter baumannii. Biochim Biophys Acta Proteins Proteom. 1867:537-547. |
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Chaudhary A, Kumar V, Singh PK, Sharma P, Bairagya HR, Kaur P, Sharma S, Chauhan SS, Singh TP (2018) A glycoprotein from mammary gland secreted during involution promotes apoptosis: Structural and biological studies. Arch Biochem Biophys. 644:72-80. |
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Kaushik S, Iqbal N, Singh N, Sikarwar JS, Singh PK, Sharma P, Kaur P, Sharma S, Owais M, Singh TP (2018) Search of multiple hot spots on the surface of peptidyl-tRNA hydrolase: structural, binding and antibacterial studies. Biochem J.475:547-560. |
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Yadav SP, Singh PK, Sharma P, Iqbal N, Kaur P, Sharma S, Singh TP (2017) Structure and binding studies of proliferating cell nuclear antigen from Leishmania donovani. Biochim Biophys Acta Proteins Proteom. 1865:1395-1405. |
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Sirohi HV, Singh PK, Iqbal N, Sharma P, Singh AK, Kaur P, Sharma S, Singh TP (2017) Design of anti-thyroid drugs: Binding studies and structure determination of the complex of lactoperoxidase with 2-mercaptoimidazole at 2.30 Å resolution. Proteins. 85(10):1882-1890. |
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Iqbal N, Kumar M, Sharma P, Yadav SP, Kaur P, Sharma S, Singh TP (2017) Binding studies and structure determination of the recombinantly produced type-II 3-dehydroquinate dehydratase from Acinetobacter baumannii. Int J Biol Macromol.459-465. |
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Singh A, Kumar A, Gautam L, Sharma P, Sinha M, Bhushan A, Kaur P, Sharma S, Arora A, Singh TP (2014) Structural and binding studies of peptidyl-tRNA hydrolase from Pseudomonas aeruginosa provide a platform for the structure-based inhibitor design against peptidyl-tRNA hydrolase. Biochem J. 463(3):329-37. |
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Sharma P, Dube D, Sinha M, Yadav S, Kaur P, Sharma S, & Singh TP (2013) Structural insights into the dual strategy of recognition by peptidoglycan recognition protein, PGRP-S: Structure of the ternary complex of PGRP-S with lipopolysaccharide and stearic acid. Plos One. 8(1):e53756. doi: 10.1371. |
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Sharma P, Yamini S, Dube D, Singh A, Mal G, Pandey N, Sinha M, Singh AK, Dey S, Kaur P, Mitra DK, Sharma S, & Singh TP (2013) Structural Basis of the Binding of Fatty Acids to Peptidoglycan Recognition Protein, PGRP-S. Arch Biochem Biophys. 529(1):1-10. doi: 10.1016. |
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Sharma P, Dube D, Sinha M, Dey S, Kaur P, Sharma S,& Singh TP (2012) Structural basis of heparin binding to camel peptidoglycan recognition protein-S. Int J Biochem Mol Biol. 3:86-94. |
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Sharma P, Dube D, Sinha M, Mishra B, Dey S, Mal G, Pathak KML, Kaur P, Mitra DK, Sharma S, & Singh TP (2011) Multi-ligand specificity of pathogen associated molecular pattern-binding site in peptidoglycan recognition protein. J Biol Chem 286:31723-30. |
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Sharma P, Dube D, Singh A, Mishra B, Singh N, Sinha M, Dey S, Kaur P, Mitra DK, Sharma S, & Singh TP (2011) Structural basis of recognition of pathogen associated molecular patterns and inhibition of proinflammatory cytokines by camel peptidoglycanrecognition protein. J Biol Chem 286, 16208-17. |
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Sharma P, Singh N, Sinha M, Sharma S, Perbandt M, Betzel C, Kaur P, Srinivasan A & Singh TP (2009) Tryptophan as a three-way switch in regulating the function of the secretory signalling glycoprotein (SPS-40) from mammary glands: structure of SPS-40 complexed with 2-methylpentane-2,4-diol at 1.6 Å resolution. Acta Cryst D 65, 375-8. |
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Sharma P, Singh N, Sinha M, Sharma S, Perbandt M, Betzel C, Kaur P, Srinivasan A & Singh TP (2008) Crystal structure of the peptidoglycan recognition protein at 1.8 Å resolution reveals dual strategy to combat infection through two independent functional homodimers. J Mol Biol 378, 923-32. |
Dr. Ethayathulla Abdul Samath |
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Additional Professor R.No.3006, 3rd Floor Teaching Block
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Recent employment details |
Additional Professor,since July 2020-Till date |
Research Interests |
The research work is focused on TP53 tumor suppressor gene plays crucial role in suppression of cancer. But the mutation in p53 leads to tumour proliferation sometimes drug resistance cancer cells. The research focused on targeting mutant p53 with structure-based drug design to restore mutant p53 to functional like wild type. We do structure-based drug design by X-ray crystallography and for drug binding and functional studies we various biophysical techniques like ITC, CD, Fluorescence and cell based functional assay in p53 mutant cell lines. The second major project in our lab is antimicrobial drug development against drug resistant bacterial pathogen. We work on bacterial cell division proteins particularly FtsZ and its associate proteins involved forming divisome protein complex assembly. We do structure-based drug design by X-ray crystallography, In silico drug screening and for drug binding studies we various biophysical techniques like ITC, CD, Fluorescence. |
Any additional information |
Associate Professor (2017 - till date): Biophysics, AIIMS, New Delhi, India Assistant Professor (2014 – 2017): Biophysics, AIIMS, New Delhi, India Research Associate (2012-2014): Texas Tech University Health Science center, Texas, USA Post doctoral Fellow (2007 - 2012): University of California San Diego, California, USA. Ph.D. (Biophysics, 2007: AllMS, New Delhi Master of Science (Biophysics, 2002): University of Madras, Chennai Bachelor of Science (Physics -2000): University of Madras, Chennai Google scholar https://scholar.google.com/citations?user=KZJOecsAAAAJ&hl=en Pubmed https://www.ncbi.nlm.nih.gov/pubmed/?term=Ethayathulla+AS%5BAuthor%5D RCSB:
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Awards and Honors |
Senior Research Fellowship awarded by CSIR, New Delhi, India. Senior Research Fellowship in the project from DST, New Delhi, India. Junior Research Fellowship in the project from DST, New Delhi, India. Junior Research Fellowship in the project from DBT, New Delhi, India. |
Recent Publications
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M.Sc. Biophysics Syllabus |
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M.Sc. Biophysics Syllabus |
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अखिल भारतीय आयुर्विज्ञान संस्थान
अंसारी नगर, नई दिल्ली - 110029
+91-11-26588500 / 26588700
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