Dr. Jyotirmoy Banerjee

Designation: Associate Professor

Room No. 11, 5th Floor, Porta Cabin, Teaching Block, AIIMS, New delhi 

Email: यह ईमेल पता spambots से संरक्षित किया जा रहा है. आप जावास्क्रिप्ट यह देखने के सक्षम होना चाहिए. ;    यह ईमेल पता spambots से संरक्षित किया जा रहा है. आप जावास्क्रिप्ट यह देखने के सक्षम होना चाहिए.    Phone: 

Phone: 011-26549324

Recent Employment Details: Associate Professor, since 2020-present 

Research Interests: Ion-channel biophysics, Patch-clamp electrophysiology, Drug-resistant epilepsy, Synaptic transmission, Molecular neuroscience

Awards & Honors:

• Best Paper Award in Basic Neuroscience category at Indian Academy of Neurology (IAN) conference held at Raipur, September, 2018.

• Lalita & Ravindra Nath International Travel Fellowship from Indian Academy of Neurosciences (IAN) for the year 2016.

• Co-Editor of the Journal Neurology India.

• Reviewing Editor Frontiers Journals.

• Member Society for Neuroscience (SfN), USA.

• Life Member Indian Epilepsy Society (IES), India

• Member Neurological Society of India (NSI), India

• Life Member Indian Academy of Neurosciences (IAN), India

• Life Associate Member Indian Academy of Neurology, India

Recent Significant Publications:

(Pubmed Link: https://pubmed.ncbi.nlm.nih.gov/?term=banerjee+jyotirmoy&sort=date)

1. Dey S, Banerjee Dixit A, Tripathi M, Doddamani RS, Sharma MC, Lalwani S, Chandra PS, Banerjee J. Altered hippocampal kynurenine pathway metabolism contribute to hyperexcitability in human mesial temporal lobe epilepsy-hippocampal sclerosis. 2021, British Journal of Pharmacology; 178:3959-3976. doi: 10.1111/bph.15534.

2. Kumar S, Shanker OR, Kumari N, Tripathi M, Chandra PS, Dixit AB, Banerjee J. Neuromodulatory effects of SARS-CoV2 infection: Possible therapeutic targets. 2021, Expert Opinion on Therapeutic Targets; 25:509-519. doi: 10.1080/14728222.2021.1953475.

3. Banerjee J, Srivastava A, Sharma D, Dey S, Tripathi M, Sharma MC, et al. Differential regulation of glutamatergic activity in the hippocampus and anterior temporal lobe by cyclin dependent kinase 5 (Cdk5) in mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE-HS). 2021, Neuroscience Letters; 761: 136096. doi: 10.1016/j.neulet.2021.136096.

4. Dey S, Doddamani R, Dixit AB, Tripathi M, Sharma MC, Chandra PS, Banerjee J. Altered spontaneous glutamatergic and GABAergic activity in the peritumoral cortex of low-grade gliomas presenting with history of seizures. 2021, Frontiers in Neuroscience; 15:689769. doi:10.3389/fnins.2021.689769

5. Sharma D, Dixit AB, Dey S, Tripathi M, Doddamani R, Sharma MC, Lalwani S, Gurjar HK, Chandra PS, Banerjee J. Increased levels of α4-containing GABA_A receptors in focal cortical dysplasia: A possible cause of benzodiazepine resistance. 2021, Neurochemistry International; 148:105084. doi: 10.1016/j.neuint.2021.105084

6. Srivastava A, Kumar K, Banerjee J, Tripathi M, Dubey V, Sharma D, Yadav N, Sharma MC, Lalwani S, Doddamani R, Chandra PS, Dixit AB. Transcriptomic profiling of high- and low-spiking regions reveals novel epileptogenic mechanisms in focal cortical dysplasia type II patients. 2021, Molecular Brain; 14:120. doi: 10.1186/s13041-021-00832-4.

7. Banerjee J, Dey S, Dixit AB, Doddamani R, Sharma MC, Garg A, et al. GABA_A Receptor-Mediated Epileptogenicity in Focal Cortical Dysplasia (FCD) Depends on Age at Epilepsy Onset. 2020, Front Cell Neurosci; 14:562811. doi: 10.3389/fncel.2020.562811

8. Banerjee J, Dey S, Dixit AB, Tripathi M, Doddamani R, Sharma MC, et al. α7 nicotinic receptors contributes to glutamatergic activity in the hippocampus of patients with mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE-HS). 2020, J Neural Transmission; 127:1441-1446. doi: 10.1007/s00702-020-02239-2.

9. Banerjee J, Tripathi M, Chandra PS, Dixit AB. Do SARS-CoV2 viral proteins have neuromodulatory properties? 2020, Neurol India; 68:274-275. doi: 10.4103/0028-3886.283760.

10. Srivastava A, Dixit AB, Paul D, Tripathi M, Sarkar C, Chandra PS, Banerjee J (2017). Comparative analysis of cytokine/chemokine regulatory networks in patients with hippocampal sclerosis (HS) and focal cortical dysplasia (FCD). Scientific Reports (Nature), 7:15904. doi: 10.1038/s41598-017-16041-w.

11. Banerjee J, Dixit AB, Srivastava A, Ramanujam B, Kakkar A, Sarkar C, Tripathi M & Chandra PS (2017). Altered glutamatergic tone reveals two distinct resting state networks at the cellular level in hippocampal sclerosis. Scientific Reports (Nature), 7:319. doi: 10.1038/s41598-017-00358-7.

12. Dixit AB, Banerjee J, Srivastava A, Tripathi M, Sarkar C, Kakkar A, Jain M, Sarat Chandra P (2016). RNA-Seq analysis of hippocampal tissues reveals novel candidate genes for drug refractory epilepsy in patients with MTLE-HS. Genomics. 107, 178–188. doi: 10.1016/j.ygeno.2016.04.001

13. Dixit AB, Tripathi M, Chandra PS & Banerjee J. (2016)Molecular Biomarkers in Drug-Resistant Epilepsy: Facts & Possibilities. International Journal of Surgery, 36, 483-491.doi: 10.1016/j.ijsu.2015.08.029

14. Banerjee J, Dixit AB, Tripathi M, Sarkar C, Gupta YK & Chandra PS. (2015) Enhanced endogenous activation of NMDA receptors in pyramidal neurons of hippocampal tissues from patients with mesial temporal lobe epilepsy: a mechanism of hyper excitation. Epilepsy Research, 117: 11-16. doi: 10.1016/j.eplepsyres.2015.08.007

15. Banerjee J, Chandra PS, Kurwale N, & Tripathi M (2014) Epileptogenic networks and drug-resistant epilepsy: Present and future perspectives of epilepsy research- Utility for the epileptologist and the epilepsy surgeon. Annals of Indian Academy of Neurology,17: 134-140. doi: 10.4103/0972-2327.128688

16. Banerjee J, Alkondon M, Albuquerque EX & Periera EFR. (2013) Contribution of CA3 and CA1 pyramidal neurons to the tonic α7 nAChR-dependent glutamatergic input to CA1 pyramidal neurons. Neuroscience Letters,554: 167-171. doi: 10.1016/j.neulet.2013.08.025

17. Banerjee J, Tripathi M and Chandra PS (2013) Understanding Complexities of Synaptic Transmission in Medically Intractable Seizures:A Paradigm of Epilepsy Research. Indian Journal of Neurosurgery, 2, 71-76. doi: 10.4103/2277-9167.110229

18. Banerjee J, Alkondon M, & Albuquerque EX. (2012) Kynurenic acid inhibits glutamatergic transmission to CA1 pyramidal neurons via α7 nAChR-dependent and -independent mechanisms. Biochemical Pharmacology, 84:1078-1087. doi: 10.1016/j.bcp.2012.07.030

19. Banerjee J, Alkondon M, Periera EFR, & Albuquerque EX. (2012) Regulation of GABAergic inputs to CA1 pyramidal neurons by nicotinic receptors and kynurenic acid. Journal of Pharmacology and Experimental Therapeutics, 341: 500-509. doi: 10.1124/jpet.111.189860

Current Lab Members: Vivek Dubey, Yogesh Aggarwal, Shreesha Nambiar, Syeda Zaidi, Mahender Kumar.

Designation

Assistant Professor

Email

Contact Number

+91-11-26594608

Research Interests

Structural Biology ; Rational Structure based Drug Design ; Multidrug Resistant Bacterial Therapeutics

Awards and Honors

INSA Young Scientist Award

DST Inspire Faculty Award  

S V Talekar Medal for the best postgraduate of Department of Biophysics (AIIMS)

Ludo Frevel Crystallography Award, ICDD, USA

Summer Training Award at ESRF, Grenoble, France (European Commission)

Chaired, Society of Young Scientists, AIIMS, New Delhi (2009-10)

IUCr Travel award to attend IUCr meeting at Osaka, Japan

Awarded CSIR-Junior Research Fellowship

Awarded CSIR Senior Research Fellowship

Gold Medalist from Maharshi Dayanand University, Rohtak

Merit certificate awarded by Higher Education Department Haryana

National Merit Scholarship

Significant Publications

Gupta A, Singh PK, Sharma P, Kaur P, Sharma S, Singh TP (2019) Structural and biochemical studies of phosphopantetheine adenylyltransferase from Acinetobacter baumannii with dephospho-coenzyme A and coenzyme A. Int J Biol Macromol. 8130: 35145-35151.

Gupta A, Singh PK, Iqbal N, Sharma P, Baraigya HR, Kaur P, Umar MS, Ahmad F, Sharma A, Owais M, Sharma S, Singh TP (2019) Structural and binding studies of phosphopantetheine adenylyl transferase from Acinetobacter baumannii. Biochim Biophys Acta Proteins Proteom. 1867:537-547.

Chaudhary A, Kumar V, Singh PK, Sharma P, Bairagya HR, Kaur P, Sharma S, Chauhan SS, Singh TP (2018) A glycoprotein from mammary gland secreted during involution promotes apoptosis: Structural and biological studies. Arch Biochem Biophys. 644:72-80.

Kaushik S, Iqbal N, Singh N, Sikarwar JS, Singh PK, Sharma P, Kaur P, Sharma S, Owais M, Singh TP (2018) Search of multiple hot spots on the surface of peptidyl-tRNA hydrolase: structural, binding and antibacterial studies. Biochem J.475:547-560.

Yadav SP, Singh PK, Sharma P, Iqbal N, Kaur P, Sharma S, Singh TP (2017) Structure and binding studies of proliferating cell nuclear antigen from Leishmania donovani. Biochim Biophys Acta Proteins Proteom. 1865:1395-1405.

Sirohi HV, Singh PK, Iqbal N, Sharma P, Singh AK, Kaur P, Sharma S, Singh TP (2017) Design of anti-thyroid drugs: Binding studies and structure determination of the complex of lactoperoxidase with 2-mercaptoimidazole at 2.30 Å resolution. Proteins. 85(10):1882-1890.

Iqbal N, Kumar M, Sharma P, Yadav SP, Kaur P, Sharma S, Singh TP (2017) Binding studies and structure determination of the recombinantly produced type-II 3-dehydroquinate dehydratase from Acinetobacter baumannii. Int J Biol Macromol.459-465.

Singh A, Kumar A, Gautam L, Sharma P, Sinha M, Bhushan A, Kaur P, Sharma S, Arora A, Singh TP (2014) Structural and binding studies of peptidyl-tRNA hydrolase from Pseudomonas aeruginosa provide a platform for the structure-based inhibitor design against peptidyl-tRNA hydrolase. Biochem J. 463(3):329-37.

Sharma P, Dube D, Sinha M, Yadav S, Kaur P, Sharma S, & Singh TP (2013) Structural insights into the dual strategy of recognition by peptidoglycan recognition protein, PGRP-S: Structure of the ternary complex of PGRP-S with lipopolysaccharide and stearic acid. Plos One. 8(1):e53756. doi: 10.1371.

Sharma P, Yamini S, Dube D, Singh A, Mal G, Pandey N, Sinha M, Singh AK, Dey S, Kaur P, Mitra DK, Sharma S, & Singh TP (2013) Structural Basis of the Binding of Fatty Acids to Peptidoglycan Recognition Protein, PGRP-S. Arch Biochem Biophys. 529(1):1-10. doi: 10.1016.

Sharma P, Dube D, Sinha M, Dey S, Kaur P, Sharma S,& Singh TP (2012) Structural basis of heparin binding to camel peptidoglycan recognition protein-S. Int J Biochem Mol Biol. 3:86-94.

Sharma P, Dube D, Sinha M, Mishra B, Dey S, Mal G, Pathak KML, Kaur P, Mitra DK, Sharma S, & Singh TP (2011) Multi-ligand specificity of pathogen associated molecular pattern-binding site in peptidoglycan recognition protein. J Biol Chem 286:31723-30.

Sharma P, Dube D, Singh A, Mishra B, Singh N, Sinha M, Dey S, Kaur P, Mitra DK, Sharma S, & Singh TP (2011) Structural basis of recognition of pathogen associated molecular patterns and inhibition of proinflammatory cytokines by camel peptidoglycanrecognition protein. J Biol Chem 286, 16208-17.

Sharma P, Singh N, Sinha M, Sharma S, Perbandt M, Betzel C, Kaur P, Srinivasan A & Singh TP (2009) Tryptophan as a three-way switch in regulating the function of the secretory signalling glycoprotein (SPS-40) from mammary glands: structure of SPS-40 complexed with 2-methylpentane-2,4-diol at 1.6 Å resolution. Acta Cryst D 65, 375-8.

Sharma P, Singh N, Sinha M, Sharma S, Perbandt M, Betzel C, Kaur P, Srinivasan A & Singh TP (2008) Crystal structure of the peptidoglycan recognition protein at 1.8 Å resolution reveals dual strategy to combat infection through two independent functional homodimers. J Mol Biol 378, 923-32.    

Dr. Ethayathulla Abdul Samath

Additional Professor

R.No.3006, 3rd Floor Teaching Block
All India Institute of Medical Sciences
Ansari Nagar, New Delhi Email Id: यह ईमेल पता spambots से संरक्षित किया जा रहा है. आप जावास्क्रिप्ट यह देखने के सक्षम होना चाहिए.
Phone (O) +91- 11 26594816 / 26593351

Recent employment details

Additional Professor,since July 2020-Till date
Associate Professor, since July 2017-June 2020
Assistant Professor,since June 2014-June 2017

Research Interests

The research work is focused on TP53 tumor suppressor gene plays crucial role in suppression of cancer. But the mutation in p53 leads to tumour proliferation sometimes drug resistance cancer cells. The research focused on targeting mutant p53 with structure-based drug design to restore mutant p53 to functional like wild type. We do structure-based drug design by X-ray crystallography and for drug binding and functional studies we various biophysical techniques like ITC, CD, Fluorescence and cell based functional assay in p53 mutant cell lines.

The second major project in our lab is antimicrobial drug development against drug resistant bacterial pathogen. We work on bacterial cell division proteins particularly FtsZ and its associate proteins involved forming divisome protein complex assembly. We do structure-based drug design by X-ray crystallography, In silico drug screening and for drug binding studies we various biophysical techniques like ITC, CD, Fluorescence.

Any additional information  

Associate Professor (2017 - till date): Biophysics, AIIMS, New Delhi, India

Assistant Professor (2014 – 2017): Biophysics, AIIMS, New Delhi, India

Research Associate (2012-2014): Texas Tech University Health Science center, Texas, USA

Post doctoral Fellow (2007 - 2012):  University of California San Diego, California, USA.

Ph.D. (Biophysics, 2007: AllMS, New Delhi

Master of Science (Biophysics, 2002): University of Madras, Chennai

Bachelor of Science (Physics -2000): University of Madras, Chennai

Google scholar

https://scholar.google.com/citations?user=KZJOecsAAAAJ&hl=en

Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/?term=Ethayathulla+AS%5BAuthor%5D

RCSB:

http://www.rcsb.org/pdb/results/results.do?tabtoshow=Current&qrid=C3644177&startAt=0&newsortfield=Release%20Date%20Descending

Awards and Honors

Senior Research Fellowship awarded by CSIR, New Delhi, India.

Senior Research Fellowship in the project from DST, New Delhi, India.

Junior Research Fellowship in the project from DST, New Delhi, India.

Junior Research Fellowship in the project from DBT, New Delhi, India.

Recent Publications

1. Yadav P, Kumar M, Bansal R, Kaur P, Ethayathulla AS. Structure model of ferrochelatase from Salmonella Typhi elucidating metalation mechanism. Int J Biol Macromol. 2019 Apr 15;127:585-593.
2. Bansal R, Haque MA, Yadav P, Gupta D, Ethayathulla AS, Hassan MI, Kaur P. Estimation of structure and stability of MurE ligase from Salmonella enterica serovar Typhi. Int J Biol Macromol. 2018 Apr 1;109:375-382.
3. Gupta D, Sachdeva E, Haque MA, Rahman S, Bansal R, Ethayathulla AS, Hassan MI, Kaur P.Effect of chemical denaturants on the conformational stability of GyrB subunit of DNA gyrase from Salmonella enterica serovar Typhi.Int J Biol Macromol. 2017 May 9;103:165-174.
4. Khan MI, Gupta AK, Kumar DR, Kumar M, Ethayathulla AS, Hariprasad G.Molecular modeling of Gly80 and Ser80 variants of human group IID phospholipase A2 and their receptor complexes: potential basis for weight loss in chronic obstructive pulmonary disease.J Mol Model. 2016 Sep;22(9):232.
5. Ramos A, Tse PW, Wang J, Ethayathulla AS, Viadiu H. Sequence Variation in the Response Element Determines Binding by the Transcription Factor p73. Biochemistry. 2015 Dec 1;54(47):6961-72.
6. Tikhonova EB, Ethayathulla AS, Su Y, Hariharan P, Xie S, Guan L. A transcription blocker isolated from a designed repeat protein combinatorial library by in vivo functional screen. Sci Rep. 2015 Jan 28;5:8070.
7. Amin A, Ethayathulla AS, Guan L. Suppression of conformation-compromised mutants of Salmonella entericaserovar Typhimurium MelB. J Bacteriol. 2014;196(17):3134-9.
8. Ethayathulla AS, Yousef MS, Amin A, Leblanc G, Kaback HR, Guan L. Structure-based mechanism for Na(+)/melibiose symport by MelB. Nat Commun. 2014;5:3009.
9. Ciribilli Y, Monti P, Bisio A, Nguyen T, Ethayathulla AS, Ramos A, Foggetti G, Menichini P, Menendez D, Resnick M, Viadiu H, Fronza G, Inga A. Transactivation specificity is conserved among p53 family proteins and depends on a response element sequence code. Nucleic Acids Res. 2013 Oct;41(18):8637-53.
10. Ethayathulla AS, Nguyen HT, Viadiu H. Crystal Structures of the DNA-binding Domain Tetramer of the p53 Tumor Suppressor Family Member p73 Bound to Different Full-site Response Elements. J Biol Chem. 2013; 288(7):4744-54.
11. Ethayathulla AS, Tse P, Monti P, Nguyen S, Inga A, Fronza G, Viadiu H. Structure of p73 DNA-Binding Domain Tetramer Modulates p73 Transactivation. Proc Natl Acad Sci U S A. 2012 Apr 17;109(16):6066-71.
12. Soni BR, Hasan MI, Parmar A, Ethayathulla AS, Kumar RP, Singh NK, Sinha M, Kaur P, Yadav S, Sharma S, Madamwar D, Singh TP. Structure of the novel 14kDa fragment of alpha-subunit of phycoerythrin from the starving cyanobacterium Phormidium tenue. J Struct Biol. 2010 171(3):247-55. 
13. Mishra P, Prem Kumar R, Ethayathulla AS, Singh N, Sharma S, Perbandt M, Betzel C, Kaur P, Srinivasan A, Bhakuni V, Singh TP. Polysaccharide binding sites in hyaluronate lyase--crystal structures of native phage-encoded hyaluronate lyase and its complexes with ascorbic acid and lactose. FEBS J. 2009 276(12):3392-402.
14. Ethayathulla AS, Bessho Y, Shinkai A, Padmanabhan B, Singh TP, Kaur P, Yokoyama S. Purification, crystallization and preliminary X-ray diffraction analysis of the putative ABC transporter ATP-binding protein from Thermotoga maritima. Acta Crystallogr Sect F. 2008 (64) 498-500.