NAME: SUBRATA SINHA
यह ईमेल पता spambots से संरक्षित किया जा रहा है. आप जावास्क्रिप्ट यह देखने के सक्षम होना चाहिए. , यह ईमेल पता spambots से संरक्षित किया जा रहा है. आप जावास्क्रिप्ट यह देखने के सक्षम होना चाहिए.
Council of National Academic Awards, UK at MRC Toxicology Unit, Carshalton, UK
All India Institute of Medical Sciences, New Delhi
All India Institute of Medical Sciences, New Delhi
Central Board of Secondary Education, New Delhi
Title of Thesis: The role of oncogenes in experimental rat liver cancer
Title of Thesis: Studies of plasma membrane specific antigen of thehuman placenta
Sir Dorabjee Tata Award for the best undergraduate in Biochemistry
First Division, Distinction in Physics, Chemistry & Mathematics
DETAILS OF EMPLOYMENT
Period of work
Department of Biochemistry, All India Institute of Medical Sciences, New Delhi
National Brain Research Centre(Autonomous institution of the Dept of Biotechnology) Manesar, Haryana
Additional charge Regional Centre of Biotechnology (another DBT institute)
Department of Biochemistry All India Institute of Medical Sciences, New Delhi
MRC Toxicology Unit, Carshalton, England [currently relocated to Leicester University(on leave from the Indian Councilof Medical Research)
India Council of Medical Research,
Talent Search Scheme (posted at the National Institute of Immunology, New Delhi).
All India Institute of Medical Sciences, New Delhi
Professor and Head, resumed charge after deputation
Professor and Head
Smith and Nephew Fellow and Non-Clinical-Scientist-1A Also registered for PhD
Junior Resident (Biochemistry)(Enrolled for M.D.)
Since 29 Dec 2017
on deputation from AIIMS 28 June 2010 to 28 Dec 2017
Nov 2015- Oct 2016
December 1998 till 28thJuly, 2010 (Head of Dept. since 2003)
July 1996 to November 1998
July 1992 to July 1996
May 1988 to July 1992
May 1984 to December 1986
January 1984 to till May 1988
on leave from May 1984 to December 1986
January 1980 to December
AWARDS AND HONOURS
Fellowships of academies and other bodies
- Fellow of the Indian National Science Academy, 2006 (Sectional Committee for Medical Sciences 2008 -11, Convener , Health Sciences 2015 -18 ), Vice President 2020-210)
- Fellow of the Indian Academy of Sciences, 2003 (member Sectional Committee for Medicine 2013, Convener of Committee 2015 -18)
- Indian Academy of Neurosciences 2011 (Dean of the Academy 2012-14, President, 2015-17)
- Fellow of the National Academy of Medical Sciences, 2007
- Fellow of National Academy of Sciences, 2005
- Member, Guha Research Conference, 2008
- J C Bose fellowship of the DST, 2016
- Awarded ICMR Senior Biomedical Fellowship, Indian Council of Medical Research for visit to CBER, FDA, USA, 2008
- Swarnajayanti fellowship of the Dept of Science and Technology (1998)
- Indian National Science Academy Exchange Fellowship for UK (1997)
Awards, Named Orations and Plenary Lectures
- Sun Pharma Award Medical Sciences – Basic research, for 2015
- Awarded the Vishwanath Memorial Lecture Award of the Indian National Science Academy 2015
- Awarded the V S Khanolkar Memorial Lecture of the National Academy of Medical Sciences for 2014
- Awarded the D N Prasad Memorial Lecture of the National Institute of Mental Health and Neurosciences, Bangalore, 2012
- Awarded the Seth G. S. Medical College & KEM Hospital Oration Award of the Association of Clinical Biochemists of India, 2013
- Chief Guest and Inaugural Lecturer for National Symposium on the theme “Neurosciences and Its Future Prospects” by Interdisciplinary Brain Research Centre(IBRC), Faculty of Medicine, Aligarh Muslim University, 2014.
- Inaugural Lecture, 2nd International Conference on Perspectives of Cell Signaling and Molecular Medicine, to 11 January, 2012, Bose Institure, Kolkata
- Inaugural Lecture, Brain Storming Meeting on Translational Research in Neuroscience, Sept 16-17,2011, Banaras Hindu University, Varanasi
- Chief Guest and Speaker, National Science Day celebrations, University of Hyderabad, 2006
- Awarded the Kodalivimad Oration of the Association of Medical Biochemists of India (2000).
PUBLICATIONS (Last 5 years)
Tumour Biology and genetics (last author as corresponding author unless otherwise indicated)
1. Prajapati B, Fatma M, Fatima M, Khan MT, Sinha S and Seth PK Identification of lncRNAs Associated With Neuroblastoma in Cross-Sectional Databases: Potential Biomarkers. Front. Mol. Neurosci. (2019) 12:293. doi: 10.3389/fnmol.2019.00293 Joint corresponding author
2. Prajapati B, Fatma M, Maddhesiya P, Sodhi MK, Fatima M, Dargar T, Bhagat R, Seth P,Sinha S.Identification and epigenetic analysis of divergent long non-coding RNAs in multilineage differentiation of human Neural Progenitor Cells.RNA Biol. 2019 Jan;16(1):13-24. doi: 10.1080/15476286.2018.1553482. Epub 2018 Dec 27
3. Devasenapathy S, Midha R, Naskar T, Mehta A, Prajapati B, Ummekulsum M, Sagar R, Singh NC, Sinha S. A pilot Indian family-based association study between dyslexia and Reelin pathway genes, DCDC2 and ROBO1, identifies modest association with a triallelic unit TAT in the gene RELN Asian J Psychiatr. 2018 Aug 25;37:121-129. doi: 10.1016/j.ajp.2018.08.020. [Epub ahead of print] PMID: 30199849
4.Jalota A, Kumar M, Das BC, Yadav AK, Chosdol K, Sinha S. A drug combination targeting hypoxia induced chemoresistance and stemness in glioma cells. Oncotarget. 2018 Apr 6;9(26):18351-18366. doi: 10.18632/oncotarget.24839. eCollection 2018 Apr 6. PMID: 29719610
5. Srivastava C, Irshad K, Dikshit B, Chattopadhyay P, Sarkar C, Gupta D K, Sinha S, Chosdol K. FAT1 modulates EMT and stemness genes expression in hypoxic glioblastoma.Int J Cancer. 2018 Feb 15;142(4):805-812. doi: 10.1002/ijc.31092. Epub 2017 Oct 17. PMID:28994107
6. Naskar T, Faruq M, Banerjee P, Khan M, Midha R, Kumari R, Devasenapathy S, Prajapati B, Sengupta S, Jain D, Mukerji M, Singh NC, Sinha S.Ancestral Variations of the PCDHG Gene Cluster Predispose to Dyslexia in a Multiplex Family. EBioMedicine. 2018 Feb;28:168-179. doi: 10.1016/j.ebiom.2017.12.031. Epub 2018 Jan 9.PMID: 29409727
7. Madan E, Dikshit B, Gowda SH, Srivastava C, Sarkar C, Chattopadhyay P, Sinha S, Chosdol K. FAT1 is a novel upstream regulator of HIF1α and invasion of high grade glioma. Int J Cancer. 2016 Dec 1;139(11):2570-82. doi: 10.1002/ijc.30386. Epub 2016 Aug 29Joint corresponding author
8. Jalota A, Kumar M, Das BC, Yadav AK, Chosdol K, Sinha S.Synergistic increase in efficacy of a combination of 2-deoxy-D-glucose and cisplatin in normoxia and hypoxia: switch from autophagy to apoptosis. Tumour Biol. 2016 Jun 15 doi: 10.1007/s13277-016-5089-8
9. Bhagat M, Palanichamy JK, RamalingamP,Mudassir M, Irshad K, Chosdol K, Sarkar C, SethP,Goswami S, Sinha S, Chattopadhyay P. HIF-2 mediates a marked increase in migration and stemnesscharacteristics in a subset of glioma cells under hypoxia by activatingan Oct-4/Sox-2-Mena (INV) axis. The International Journal of Biochemistry & Cell Biology 74 (2016) 60–71.
10. Kumar M, Mani P, Pratheesh P, Chandra S, Jeyakkodi M, Chattopadhyay P, Sarkar DP, Dagger and Sinha S Membrane fusion mediated targeted cytosolic drug delivery through scFv engineered Sendai viral envelopes Current Molecular Medicine 2015 15 386 – 400.
11. Khan I, Zakaria MK, Kumar M, Mani P, Chattopadhyay P, Sarkar DP, SinhaS. Erratum to: A novel placental like alkaline phosphatase promoter driven transcriptional silencing combined with single chain variable fragment antibody based virosomal delivery for neoplastic cell targeting. J Transl Med. 2015 Sep 14;13:300. doi: 10.1186/s12967-015-0643-5. No abstract available PMID: 26370128.
12. Kumar M, Khan I, Sinha S. Nature of immobilization surface affects antibody specificity to placental alkaline phosphatase. J Immunoassay Immunochem. 2015;36(4):405-13. doi: 10.1080/15321819.2014.973117 PMID: 25321174
13. Kassab MA, Mudassir M, Singh A, N M, Bhagat M, Palanichamy JK, Ramalingam P, Chosdol K, Sinha S, Chattopadhyay P. Gene Silencing and Activation of Human Papillomavirus 18 Is Modulated by Sense Promoter Associated RNA in Bidirectionally Transcribed Long Control Region.PLoS One. 2015 Jun 5;10(6)
14. Irshad K, Mohapatra S.K., Srivastava C, Garg H, Mishra S, Dikshit B, Sarkar C, Gupta D, Sarat PC, Chattopadhyay P, Sinha S*;Chosdol K. A combined gene signature of hypoxia and Notch pathway in human glioblastoma and its prognostic relevance". PLOS One 2015 March 3 DOI:10.1371/journal.pone.0118201. eCollection 2015.PMID:25734817.Joint corresponding author
15. Shahi MH, Zazpe I, Afzal M, Sinha S, Rebhun RB, Meléndez B, Rey JA, CastresanaJS.Epigenetic regulation of human hedgehog interacting protein in glioma cell lines and primary tumorsamples.Tumour Biol. 2015 Apr;36(4):2383-91. doi: 10.1007/s13277-014-2846-4. Epub 2014 Nov 22.
16. Zakaria M, Khan I, Mani P, Chattopadhyay P, Sarkar DP, Sinha S. Combination of hepatocyte specific delivery and transformation dependent expression of shRNA inducing transcriptional gene silencing of c-Myc promoter in hepatocellular carcinoma cells. BMC Cancer 2014, 14:582 (10 August 2014)
17. Ramalingam P, Palanichamy JK, Singh A, Das P, Bhagat M, Kassab MA, Sinha S, Chattopadhyay P.Biogenesis of intronic miRNAs located in clusters by independent transcription and alternative splicing. RNA. 2014 Jan; 20(1):76-87. doi: 10.1261/rna.041814.113. Epub 2013 Nov 13.
18. Dikshit B, Irshad K, Madan E, Aggarwal N, Sarkar C, Chandra PS, Gupta DK, Chattopadhyay P, Sinha S, Chosdol K. FAT1 acts as an upstream regulator of oncogenic and inflammatory pathways, via PDCD4, in glioma cells.Oncogene. 2013 Aug 15;32(33):3798-808. Joint corresponding author
IMMUNOLOGY AND INFECTIOUS DISEASE BIOLOGY
19. Isolation and Characterization of Cross-Neutralizing Human Anti-V3 Single-Chain Variable Fragments (scFvs) Against HIV-1 from an Antigen Preselected Phage Library. Kumar R, Kumari R, Khan L, Sankhyan A, Parray HA, Tiwari A, Wig N, Sinha S, Luthra K. ApplBiochemBiotechnol. 2018 Aug 28. doi: 10.1007/s12010-018-2862-8. [Epub ahead of print] PMID: 30151637
20. Kumar S, Kumar R, Khan L, Makhdoomi MA, Thiruvengadam R, Mohata M, Agarwal M, Lodha R, Kabra SK, Sinha S, Luthra K.CD4-Binding Site Directed Cross-Neutralizing scFvMonoclonals from HIV-1 Subtype C Infected Indian Children.Front Immunol. 2017 Nov 15;8:1568. doi: 10.3389/fimmu.2017.01568. e Collection 2017. PMID; 2918785
21. Khan L, Kumar R, Thiruvengadam R, Parray HA, Makhdoomi MA, Kumar S, Aggarwal H, Mohata M, Hussain AW, Das R, Varadarajan R, Bhattacharya J, Vajpayee M, Murugavel KG, Solomon S, Sinha S, Luthra K. Cross-neutralizing anti-HIV-1 human single chain variable fragments(scFvs) against CD4 binding site and N332 glycan identified from a recombinant phage library. Sci Rep. 2017 Mar 23;7:45163. doi: 10.1038/srep45163
22. Sankhyan A, Sharma C, Dutta D, Sharma T, Chosdol K, Wakita T, Watashi W, Awasthi A, Acharya SK, Khanna N, Tiwari A and Sinha S. Inhibition of preS1-hepatocyte interaction by an array of recombinant human antibodies from naturally recovered individuals. Scientific Reports 2016 6: 21240 doi: 10.1038/srep21240.
23. Kumar R, Basu A, Sinha S, Das M, Tripathi P, Jain A, Kumar C, Atam V, Khan S and Singh AS. Role of oral minocycline in acute encephalitis syndrome in India – a randomized controlled trial. BMC Infectious Diseases 2016 doi:10.1186/s12879-016-1385-6.
24.Kulshreshtha P, Tiwari A, Priyanka, Joon S, Sinha S, Bhatnagar R. Investigation of a panel of monoclonal antibodies and polyclonal sera against anthrax toxins resulted in identification of an anti-lethal factor antibody with disease-enhancing characteristics.MolImmunol. 2015 Sep 9. pii: S0161-5890(15)30027-4. doi: 10.1016/j.molimm.2015.07.019.
25. Singh A, Palanichamy JK, Ramalingam P, Kassab MA, Bhagat M, Andrabi R, Luthra K, Sinha S, Chattopadhyay P. Long-term suppression of HIV-1C virus production in human peripheral blood mononuclear cells by LTR heterochromatization with a short double-stranded RNA. J AntimicrobChemother. 2014 Feb;69(2):404-15. doi: 10.1093/jac/dkt348. Epub 2013 Sep 10
26. Kumar R, Andrabi R, Tiwari A, Sankaran S. P, Wig N, Dutta D, Sankhyan A, Khan L, Sinha S, Luthra K. A novel strategy for efficient production of anti-V3 human scFvs against HIV-1 clade C, BMC Biotechnology Online Publication, 15 November 2012; doi:10.1186/1472-6750-12-87 (joint corresponding author)
1. A recombinant mouse-human Chimaeric Fab against Hepatitis B surface antigen. B Bose, Navin Khanna, S K Acharya and S Sinha ( PCT filed, national phase granted in South Africa No 2009/04338 on 26 May 2010, Indian Patent No 251904 (2704/DEL/2006) Dated 18/12/2006, granted on 16/04/2012 and others are in progress).- Jointly by Dept. of Biotechnology, AIIMS and ICGEB. Indian Patent Granted on
2. A humanized high Affinity Recombinant antibody against Hepatitis B surface antigen. A Tiwari, Navin Khanna, S K Acharya and S Sinha. For India: Publication number: IN2008DE190, Filing Date:Jan 23, 2008, Original published format:IN DE01902008; International Application No: PCT/IN2008/000796, International Filing Date: Dec 2, 20086: Publication number: US 2011/0046354 A1 . Filing date: Dec 2, 2008, Current U.S. Classification: 530/387.3; US Patent granted For Europe:Publication number: EP2250198 A1, Publication date: Nov 17, 2011; Filing Date:Dec 2, 2008, European Classification: C07K 16/08A12 Jointly by Dept. of Biotechnology, AIIMS and ICGEB
3. A novel small interfering RNA (siRNA) targeting the Human Papilloma Virus – 16 enhancer region leading to down regulation of the expression of viral oncogenic mRNA’s E6 & E7 in a human Papilloma Virus – 16 (HPV-16) positive cervical carcinoma cell line, and its novel genomic target. (Patent No. 263597 dt 5/11/14; Indian Patent Application No. 2746/Del/2008 dt. 4/12/2008, DBT and AIIMS) J Palanichamy, S Sinha, P Chattopadhyay.
4. A novel small interfering RNA (siRNA) directed against ME lal binding region in the P2 promoter of proto-oncogene c-myc results in its transcriptional gene silencing. M Mehndiratta, S. Sinha. P Chattopadhyay. (Patent No, 263225 dt 15/10/14; Indian Patent Application No, 2747/Del/2008 dt 4/12/2008, DBT and AIIMS).”
5. Use of the FAT1 gene and its products, including RNA, protein and the derivatives of the same, as suitable molecule/s for either inflammation or cancer and the associated phenotype and the processes linking the same and also as a biomarker for the above processes. K Chosdol, B Dikshit and S Sinha (Indian patent filed, 45/DEL/2012PCT filed on 5 Jan 2012, PCT/IB2013/050086, filed on 4 Jan 2013).(Jointly by DBT, AIIMS and NBRC). US Patent granted 2017
6. Placental Like Alkaline Phosphatase (PLAP) Promoter Mediated Cell Targeting S Sinha, I Khan, K Ahmad, K Chosdol and P Chattopadhyay. (Provisional Indian Patent No 1400/DEL/2013. Filed on 10 May, 2013, PCT/IB2014/061350 dated May 10, 2014, US Patent Granted - Application No.: 14/722,361 filed on September 03, 2015 (jointly by DBT, AIIMS and NBRC). US Patent granted, 2018