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अखिल भारतीय आयुर्विज्ञान संस्थान, नई दिल्ली
All India Institute Of Medical Sciences, New Delhi

Introduction

 

The major focus of the department includes the three-dimensional structure determinations of protein molecules for establishing the structure-function relationships to gain detailed insights into their biological roles and use the relevant protein structures as targets for designing new drug molecules using rational structure-based approach. In our labs, the new proteins are isolated from natural sources using tools of protein chemistry as well as produced by over expressing them using molecular biology techniques.

The structures are determined at atomic details using X-ray crystallographic methods. After successful structure determinations the structures are analyzed in great details to reveal new protein folds and for establishing functional mechanisms. The insights into protein dynamics and folding are also unraveled.

The department is also involved in the identification and characterization of new proteins by using methods of proteomics. The precise-ligand interactions are carried using binding studies. The design of new structurally specific peptides are prepared and then synthesized using both manual and automated methods. 

 

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