Dr. Alpana Sharma
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All India Institute Of Medical Sciences, New Delhi
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Dr. Alpana Sharma

Address: Room No. 3015,

                Department of Biochemistry,

                AIIMS, New Delhi

Phone: +911126546665

Email id: This email address is being protected from spambots. You need JavaScript enabled to view it.

 

Academic Details:

Degree

Subject

University/ Institution

PhD

Biochemistry

JN Medical College, AMU, Aligarh

M.Phil.

Biochemistry

JN Med College,  AMU, Aligarh

M.Sc.

Biochemistry

Aligarh Muslim University

 

Positions held:

 

Position

Department

University/ Institution

Dates

Professor

Biochemistry

AIIMS, New Delhi

2014-till date

Additional Professor

Biochemistry

AIIMS, New Delhi

2010-2014

Associate Professor

Biochemistry

AIIMS, New Delhi

2007-2010

Assistant Professor

Biochemistry

AIIMS, New Delhi

2003-2007

Awards:

       AACR-NCI International Investigator Opportunity Grant Awarded by American Association for Cancer Research, Philadelphia, USA (Dec 2009)

       Indo French Fellowship awarded in the year 1985-86.     

       Lady Tata Memorial Trust fellowship, Bombay 1983-1985

       Travel grant from IGCS Prague , Czech Republic, 2010

       Elected Treasurer, Indian Immunology Society

       Elected Secretary, Indian Academy of Biomedical Sciences

Memberships:

1.    Active member of American Association for Cancer Research

2.    Member, International Gynaecological Cancer Society

3.    Member, National Academy of Medical Sciences, New Delhi

4.    Member, National Academy of Sciences, Allahabad

5.    Life membership of:

·      Indian Academy of Biomedical Sciences

·      Indian Immunology Society,

·      Indian Association for Cancer Research

·      Association of Clinical Biochemists of India

·      Free radical Society of India

 

Research Focus of the Lab

The primary goal of the lab is to understand major biological processes at the molecular level with the ultimate aim of alleviating human diseases and to explore the diagnostic/prognostic markers along with novel therapeutic targets/agents. Our research focuses on the importance of the bone marrow microenvironment in multiple myeloma, role of T cells in immune evasion by tumour cells in urinary bladder and cervical cancer and to explore the anti-cancer potential of natural products. Our lab also aims to decipher the immunopathogenesis of autoimmune skin disorders (PV and Vitiligo).

 

Our most recent Research Goals:

1.      To explore the potential mechanism of chemo-resistance in cervical cancer with a special focus on autophagy and its associated molecules.

2.      To elucidate the Hyaluronic acid signalling cascade and the role of RASSF1A in modulation of hippo pathway in Urothelial Carcinoma of Bladder

3.      To explore the role of shelterin complex and ECM proteins and their regulation by microRNA in Multiple Myeloma.

4.      To unravel the mechanisms involved with immune evasion employed in tumor sustenance.

5.      To study the role of γδ-T-cells and dendritic cells in immunopathogenesis of skin disorders.

 

 

List of Lab members (Including technicians and attendants)

Postdoctoral Fellows

  • Dr. Rehan Khan
  • Dr. Reeta Rai
  • Dr. Priyanka Verma
  • Dr. Chaman Saini

PhD Students

  • VivekAnand
  • Raman Kumar
  • MadhuramKhandelwal
  • Nidhi Gupta
  • Dayasagar Das
  • AyantikaTalukdar
  • Mohd. Tarique
  • K.V. Santosh Babu

M.Sc. Student

  • Ashu

Technicians/Attendants

  • Jaipal Singh Rana (Lab Technician)
  • Ashok Kumar (Project Attendant)

 

Positions Available -None

 

Key publications:

1.    Asothai R, Anand V, Das D, Antil PS, Khandpur S, Sharma VK, Sharma A. Distinctive Treg associated CCR4-CCL22 expression profile with altered frequency of Th17/Treg cell in the immunopathogenesis of Pemphigus Vulgaris. Immunobiology. 2015 Oct;220(10):1129-35.

2.    Gupta N, Khan R, Kumar R, Kumar L, Sharma A. Versican and its associated molecules: potential diagnostic markers for multiple myeloma. ClinChimActa. 2015 Mar 10;442:119-24.

3.    Khan R, Gupta N, Kumar R, Sharma M, Kumar L, Sharma A. Augmented expression of urokinase plasminogen activator and extracellular matrix proteins associates with multiple myeloma progression. ClinExp Metastasis. 2014 Jun;31(5):585-93.

4.    Chugh S, Anand V, Swaroop L, Sharma M, Seth A, Sharma A. Involvement of Th17 cells in patients of urothelial carcinoma of bladder. Hum Immunol. 2013 Oct;74(10):1258-62.

5.    Khan R, Sharma M, Kumar L, Husain SA, Sharma A. Interrelationship and expression profiling of cyclooxygenase and angiogenic factors in Indian patients with multiple myeloma. Ann Hematol. 2013 Jan;92(1):101-9.

6.    Bhagirath D, Abrol N, Khan R, Sharma M, Seth A, Sharma A. Expression of CD147, BIGH3 and Stathmin and their potential role as diagnostic marker in patients with urothelial carcinoma of the bladder. ClinChimActa. 2012 Oct 9;413(19-20):1641-6.

7.    Khan R, Gupta S, Sharma A. Circulatory levels of T-cell cytokines (interleukin [IL]-2, IL-4, IL-17, and transforming growth factor-β) in patients with vitiligo. J Am AcadDermatol. 2012 Mar;66(3):510-1.

8.    Sharma M, Satyam A, Abhishek A, Khan R, Rajappa M, Sharma A. Molecular and circulatory expression of insulin growth factors in Indian females with advanced cervical cancer. Asian Pac J Cancer Prev. 2012;13(12):6475-9.

9.    Joshi S, Khan R, Sharma M, Kumar L, Sharma A. Angiopoietin-2: a potential novel diagnostic marker in multiple myeloma. ClinBiochem. 2011 Jun;44(8-9):590-5.

10.              Khatri R; Mukhopadhyay K; Verma KK; Sethuraman G; Sharma, A (2011) Genetic predisposition due to lower producers of IL-10 (-) 1082 G>A & (-) 819 C>Tloci but no endowment due to IFN-g (+) 874 A>T locus to Parthenium Dermatitis in Indian cohort. British J Dermatol .2011; 165:115-122.

Funding Source

  • Indian Council of Medical Research
  • Department of Biotechnology, Govt of India
  • Council of Scientific & Industrial Research
  • AIIMS, New Delhi

 

Research Group Members

 

1.    Dr. Rehan Khan, National, PDF, DST

    Dr. Rehan Khan has completed his PhD in Biosciences from JamiaMilliaIslamia, New Delhi. His doctoral thesis was on the Effect of Cinnamon Extract on Angiogenesis and Cyclooxygenase in Multiple Myeloma. The central theme of his overall research is the role of microenvironment in cancer progression and in case of Vitiligo; oxidative stress, autoimmunity, and neural hypothesis. He has also been involved with a search for non-invasive biomarker in urothelial carcinoma of bladder cancer using proteomics approach and in defining the role of genetic, epigenetic and immunological components in the pathogenesis of active Alopecia Areata. Currently, he is a National Post-Doctoral Fellow (DST) and is presently exploring the potential mechanism behind chemoresistance in cervical cancer. 

Mr. MohdTarique completed his M.Sc. in Biotechnology at JamiaHamdard University, New Delhi. After that he registered for PhD programme in the Department of Biochemistry, AIIMS. Currently, He is evaluating the mechanism of conversion of regulatory T cells towards IFN-γ secreting cells using in vitro cytokine. In addition to this he is also examining the functional interaction of B regs, Th17 cells and Tregs in leprosy patients. Work focus also turned towards analysis of gamma delta cells in leprosy patients. Recently, he unravelled the polymorphisms of 13 different cytokines genes in leprosy patients in patients associated with slow and fast progression of disease? (Cytokine.2015 May; 73(1):61-5.)

 

1.    Mr. Raman Kumar, Final Year PhD student

Mr. Raman Kumar completed his M.Sc. in Biochemistry from JamiaMilliaIslamia University, Delhi. He is working on Multiple Myeloma. His PhD title is “Exploring the role of shelterin complex and its associated molecules in Multiple Myeloma”.

 

 

2.    Mr. VivekAnand, PhD student

Mr. VivekAnand completed his M.Sc. in Biochemistry from Patna University and M.Tech. in Biotechnology from Anna University, Chennai. His area of interests are Immunology and Tumor biology. At present he is working on Hyaluronic acid signalling cascade in Urothelial Carcinoma of Bladder.

 

3.    Ms. MadhuramKhandelwal, Fourth Year PhD student

Ms. MadhuramKhandelwal completed her M.Sc. in Medical Biochemistry from Rajasthan University of Health and Sciences. She is working on Bladder Cancer. Her PhD title is “Role of RASSF1A in modulation of hippo pathway in Urothelial Carcinoma of Bladder”.

 

4.    Ms. Nidhi Gupta, Third Year PhD student

Ms. Nidhi Gupta completed her M.Sc. in Biochemistry from AIIMS, New Delhi. She is working on Multiple Myeloma. Her PhD title is “Exploring the role of Versican and its regulation by microRNA in Multiple Myeloma”.

 

5.    Mr. Dayasagar Das, Second Year PhD student

Mr. Dayasagar Das completed his M.Sc. in Medical Microbiology from Kasturba Medical College,Manipal University. His field of interest is Immunology and currently he is working on autoimmune blistering skin disease, Pemphigus Vulgaris. His PhD title is “Role of gamma delta T-cells in immunopathogenesis of Pemphigus Vulgaris”.

 

6.    Mr. Santosh Babu, First Year PhD student

Mr. Santosh Babu completed his M.Sc. in Medical Microbiology from Sikkim Manipal University. He is working on Vitiligo. His PhD title is “Role of gamma delta T-cells in immunopathogenesis of Vitiligo”.

7.    Ms. Ashu, Second Year M.Sc. student

Ms. Ashu is currently pursuing M.Sc Biochemistry from AIIMS. She has completed her graduation from University of Delhi in Biochemistry. Her M.Sc. title is “Role of dendritic cells in immunopathogenesis of Vitiligo”.

 

8.        Mr. Jaipal Singh Rana, Junior Lab Technologist

Presently, he is working as Junior Lab Technologist and joined AIIMS in 1988. He has 28 years of experience in research related activities such as supervision and maintenance of equipments. He helps in upkeep of culture room and culture work.

 

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