Dr. Archana Singh
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All India Institute Of Medical Sciences, New Delhi
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Dr. Archana Singh

 

 

Sitting: Sudhasini Panda, Dr. Archana Singh, Mrs. Purinma Gola, Standing: Dr. Diravayaseelan M, Krishna kumarSahu, Seth Mohd. Ansari, Dr. Ambrish Tiwari 

 

Address: Room no. 3022,

                Dept. of Biochemistry,

                AIIMS, New Delhi.

Phone: 011-26593467

Email id: This email address is being protected from spambots. You need JavaScript enabled to view it. , This email address is being protected from spambots. You need JavaScript enabled to view it.

 

Academic Details:

Degree

Subject

University/ Institution

Year

M.B.B.S.

Bachelor of medicine and surgery

Maulana Azad Medical College, Delhi University

1998-2003

M.D.

Biochemistry

Lady Hardinge Medical College, Delhi University

2005-2008

 

Positions held:

Position

Department

University/ Institution

Dates

Senior resident

Biochemistry

Lady Hardinge Medical college

27 May 2008 - 30 Dec 2009

Assistant Professor

Biochemistry

University College of Medical Sciences

31 Dec 2009 - 13 June 2014

Assistant Professor

Biochemistry

All India Institute of Medical Sciences

14 June 2014 -till present

 

Notable Awards and Society Memberships:

Life member of the Association of the Medical Biochemist of India (AMBI), Association of the Clinical Biochemists of India (ACBI), Indian Society for Atherosclerosis Research (ISAR), Indian Immunology Society

Executive Member of AMBI Delhi Chapter and ISAR Delhi chapter.

Trained on medical laboratories quality management system and   internal audit as per IS/ISO 15189 from National Institute of training for standardization, Bureau of Indian Standards, Noida, Delhi.

Work on various aspects of complicated pregnancy has won three awards namely Dr. C Sita Devi Award for best paper twice at Association of Clinical biochemists of India in 2010 and 2013 and International Federation of Clinical Chemistry Roche Travel Scholarship to attend and present poster at Asian Pacific Federation of Clinical Biochemistry 2013, Bali, Indonesia 2013.

Resource person (course writer and Editor) in development of course material for Bachelor in Medical Laboratory Technology (BMLT) for IGNOU.

Research Focus of the Lab:

In the past, she has been working on various aspects of women health, to understand mainly genetic and Immunological aspect of pre-eclampsia and intra uterine growth restriction, also involving development of new treatment modalities with respect to nitric oxide. She and her team have published about seven original studies so far on this aspect. Her work on various aspect of complicated pregnancy has won three awards as mentioned above. 

Presently, she is working on biochemical, genetic and immunological host factors of tuberculosis in understanding disease pathophysiology and development of diagnostic biomarkers for identification of latent TB among household contacts. She is also involved in development of new adjuvant therapy in treatment of pulmonary TB.

Ongoing Research Project:

Tuberculosis

 -To study the expression of nitric oxide and inducible nitric oxide synthase (iNOS) and their correlation with iNOS gene polymorphic variants in tuberculosis patients and controls (M.D. thesis Supervisor) (ICMR PG thesis grant)

-Study of vitamin D receptor (VDR) and Cathelicidin expression and their correlation with Fok I polymorphism in tuberculosis (Msc thesis Supervisor) (PI, Science and engineering Research board, DST YS extramural grant)

-Serum hepcidin levels: it’s correlation with ferroportin expression and localization and thus iron export in pathophysiology of pulmonary tuberculosis (PI, IMRG)

-Expression of Vitamin D Binding Protein (VDBP) and plasma concentration of Vitamin D in pulmonary tuberculosis (Supervisor STS) (STS ICMR)

 Pregnancy induced hypertension

- Placental growth factor as a predictive and prognostic marker for development of pre-eclampsia in high risk patients (Co-Investigator) (IMRG)

Others

-Role of Vascular Endothelial Growth Factor’ – in management of Recurrent Respiratory

 

Papillomatosis (Co-Investigator) (IMRG)

-Correlation of Hepatic Artery Resistive Index with Portal Pressure and Serum Nitric Oxide Levels in Patients with Extra Hepatic Portal Vein Obstruction (Co-Investigator) (IMRG)

List of Lab members (Including technicians and attendants)

  1. 1.      Sudhasini  Panda (ex MSc and present PhD student)
  2. 2.      Dr. Ambrish Tiwari (MD student)
  3. 3.      Dr. Diravyaseelan M (MD student)
  4. 4.      Krishna Kumar Sahu (MSc student)
  5. 5.      Purnima Gola (Senior Laboratory Technologist)
  6. 6.      Seth Mohd Ansari ( Attendant, DST project)

Positions Available: Interested in taking JRF/research trainees/ MBBS summer fellows as and when funds are available.

Key publications

* Communicating Author

  1. 1.    Archana Singh*,Deepika Sharma, ChitraRaghunandan, JayashreeBhattacharjee.“Role of inflammatory cytokines and eNOS gene Polymorphism in pathophysiology of pre-eclampsia” . American Journal of Reproductive Immunology 2010 ;  63 (3):244-25
  2. 2.    Deepika Sharma, Archana Singh, Shubha S. Trivedi, JayashreeBhattacharjee“ Role of Endothelin and Inflammatory Cytokines in Pre-eclampsia – A Pilot North   Indian Study ” .American Journal of Reproductive Immunology 2010 ; 65(4):428-32.
  3. 3.    Tanuj Chawla, Deepika Sharma, Archana Singh* “Role of the renin angiotensin system in diabetic nephropathy”. World J Diabetes. 2010; 1(5): 141-145.
  4. 4.    Deepika Sharma, Parulgoyal, Archana Singh, Shubha S. Trivedi, JayashreeBhattacharjee. “Intergenotypic variation of oxidative stress marker of eNOS (Glu298Asp) gene polymorphism in preeclampsia”. Anatolian Journal of Obstetrics &Gynecology2010 ; 3:2 : ISSN 1308-8254
  5. 5.    Deepika Sharma, Archana Singh, Shubha S. Trivedi, JayashreeBhattacharjee. Intergenotypic Variation of Nitric Oxide and Inflammatory Markers in Preeclampsia in North Indian Population. Human Immunology 2011  ;72  (5): 436-439
  6. 6.    Deepika Sharma, S. A. Hussain, N  Akhter, Archana Singh, Shubha S. Trivedi, JayashreeBhattacharjee. Endothelial nitric oxide synthase (eNOS) gene Glu298Asp polymorphism and expression in North Indian preeclampticwomen.Pregnancy Hypertension: An International Journal of Women’s Cardiovascular Health2013; 4(1): 65-69
  7. 7.    Siddhamsetty AK, Verma SK, Kohli A, Verma A, Puri D, Singh A. Exploring time of death from potassium, sodium, chloride, glucose & calcium analysis of postmortem synovial fluid in semiarid climate. Journal of forensic legal medicine.Nov 2014;28:11-4.
  8. 8.    Archana Singh*, chitraraghunandanand  JayashreeBhattacharjee. Endothelin: link between the primary placental causes and the secondary systemic endothelial dysfunction in pathophysiology of pre-eclampsia.Obstetrics and Gynecology International Journal. June 2015; 2(3):online
  9. 9.    Shalini Singh, Archana Singh*,  Deepika Sharma, Abha Singh, M. K. Narula and  JayashreeBhattacharjee. Effect of L-Arginine on Nitric Oxide Levels in  Intrauterine  Growth Restriction and its Correlation with Fetal Outcome. Indian Journal of Clinical Biochemistry. July 2015; 30(3): 298-304.
    1. 10.  Ashok kumarAhirwar, Anju Jain, Archana singh, BinitaGoswami, M K Bhatnagar and Jayashreebhattacharjee. The study of markers of endothelial dysfunction in metabolic syndrome. HormmolBiolClin Invest Dec 2015; 24(3):131-6.

Project Financial Support received:

-          From ICMR(STS) (twice) (Indian Council of Medical Research) (one ongoing)

-          From ICMR for PG thesis of my student (ongoing)

-          DST-YS (for a period of three year) (Science and engineering Research board, Deptt of Science and Technology, Govt. of India) (ongoing)

-          Intramural research grant from parent institute  (thrice) (two as co –investigator and one as PI) (ongoing)

Patient Care: Presently, In - charge of clinical chemistry laboratory, Department of Biochemistry, All India Institute of Medical sciences, Delhi

 

1. Sudhasini Panda, PhD scholar

Sudhasini completed her B.Sc. in Biochemistry from Deshbandhu College, University of Delhi in 2014. She has completed her M.Sc. in Biochemistry from All India Institute of Medical Sciences, New Delhi in the year 2016. During her M.Sc. Dissertation, she studied the role of some of the host factors like vitamin D, Vitamin D receptor and its associated molecules in Pulmonary tuberculosis. Currently she is first year PhD. student under the guidance of Dr. Archana Singh.

 

2. Dr. Ambrish Tiwari, Junior Resident

 

Ambrish completed his MBBS from Ganesh Shankar Vidyarthi Memorial Medical College, Kanpur in 2012. He is a final year MD student under the guidance of Dr. Archana Singh. His MD dissertation focuses on role of  Nitric Oxide and its associated molecules in the pathophysiology of Pulmonary Tuberculosis.

 

3. Dr.Diravyaseelan M, Junior Resident

Diravyaseelan completed his MBBS from A.C.S. Medical college, chennai in 2014. He is first year MD student under the guidance of Dr. Archana Singh.He is working on role of Iron regulatory proteins mainly hepcidin in pathophysiology of Pulmonary Tuberculosis.

 

4. Krishna Kumar Sahu, M.Sc. scholar

Krishna Kumar completed  his B Sc in Biotechnology at Science College, Patna in 2015.He is a first year M sc student under the guidance of Dr.Archana Singh. He is working on role of Iron regulatory proteins focusing on ferroportin in pathophysiology of Pulmonary Tuberculosis.

 

5.Isha Singh, MBBS IInd Year student

 Isha is IInd year MBBS student in Aiims . she is working on Vitamin D binding protein in pathophysiology of  Pulmonary Tuberculosis.

  

6. Mrs. Purnima Gola, Senior Medical Lab Technician

 

Purnima Gola completed her B.Sc from Delhi university. She has 12 year experience in lab work in Biochemistry department of Aiims. Her nature of duties are like standardization  and estimation of various analytes via ELISA and colorimetric assay kit, Data handling and management of research samples, maintaining log book ,machine maintenance, Stock reagents, processing and keeping records of bills and other office paper work.

 

7. Seth Mohamad Ansari, Lab Attendant

 

Seth Mohamad Ansari is a certified phlebotomist and has 6 year working experience in laboratory setting in dept. of Biochemistry, Aiims. He is skilled in preparing solutions, labels tubes, specimen containers,collecting specimens and performing simple tests. Able to performs routine technical and clerical functions, operate simple lab equipment and Knows sterilization techniques

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