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अखिल भारतीय आयुर्विज्ञान संस्थान, नई दिल्ली
All India Institute Of Medical Sciences, New Delhi

Dr. Pradeep Sharma

Dr. Pradeep Sharma

 

Designation

Assistant Professor

Email

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Contact Number

+91-11-26594608 ; +91-11-26593201

Research Interests

Structural Biology ; Rational Structure based Drug Design ; Multidrug Resistant Bacterial Therapeutics

Awards and Honors

 

 

 

 

 

 

 

 

INSA Young Scientist Award

DST Inspire Faculty Award  

S V Talekar Medal for the best postgraduate of Department of Biophysics (AIIMS)

Ludo Frevel Crystallography Award, ICDD, USA

Summer Training Award at ESRF, Grenoble, France (European Commission)

Chaired, Society of Young Scientists, AIIMS, New Delhi (2009-10)

IUCr Travel award to attend IUCr meeting at Osaka, Japan

Awarded CSIR-Junior Research Fellowship

Awarded CSIR Senior Research Fellowship

Gold Medalist from Maharshi Dayanand University, Rohtak

Merit certificate awarded by Higher Education Department Haryana

National Merit Scholarship

Significant Publications

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

  

 

 

 

 

 

 

 

 

 

 

Gupta A, Singh PK, Sharma P, Kaur P, Sharma S, Singh TP (2019) Structural and biochemical studies of phosphopantetheine adenylyltransferase from Acinetobacter baumannii with dephospho-coenzyme A and coenzyme A. Int J Biol Macromol. 8130: 35145-35151.

Gupta A, Singh PK, Iqbal N, Sharma P, Baraigya HR, Kaur P, Umar MS, Ahmad F, Sharma A, Owais M, Sharma S, Singh TP (2019) Structural and binding studies of phosphopantetheine adenylyl transferase from Acinetobacter baumannii. Biochim Biophys Acta Proteins Proteom. 1867:537-547.

Chaudhary A, Kumar V, Singh PK, Sharma P, Bairagya HR, Kaur P, Sharma S, Chauhan SS, Singh TP (2018) A glycoprotein from mammary gland secreted during involution promotes apoptosis: Structural and biological studies. Arch Biochem Biophys. 644:72-80.

Kaushik S, Iqbal N, Singh N, Sikarwar JS, Singh PK, Sharma P, Kaur P, Sharma S, Owais M, Singh TP (2018) Search of multiple hot spots on the surface of peptidyl-tRNA hydrolase: structural, binding and antibacterial studies. Biochem J.475:547-560.

Yadav SP, Singh PK, Sharma P, Iqbal N, Kaur P, Sharma S, Singh TP (2017) Structure and binding studies of proliferating cell nuclear antigen from Leishmania donovani. Biochim Biophys Acta Proteins Proteom. 1865:1395-1405.

Sirohi HV, Singh PK, Iqbal N, Sharma P, Singh AK, Kaur P, Sharma S, Singh TP (2017) Design of anti-thyroid drugs: Binding studies and structure determination of the complex of lactoperoxidase with 2-mercaptoimidazole at 2.30 Å resolution. Proteins. 85(10):1882-1890.

Iqbal N, Kumar M, Sharma P, Yadav SP, Kaur P, Sharma S, Singh TP (2017) Binding studies and structure determination of the recombinantly produced type-II 3-dehydroquinate dehydratase from Acinetobacter baumannii. Int J Biol Macromol.459-465.

Singh A, Kumar A, Gautam L, Sharma P, Sinha M, Bhushan A, Kaur P, Sharma S, Arora A, Singh TP (2014) Structural and binding studies of peptidyl-tRNA hydrolase from Pseudomonas aeruginosa provide a platform for the structure-based inhibitor design against peptidyl-tRNA hydrolase. Biochem J. 463(3):329-37.

Sharma P, Dube D, Sinha M, Yadav S, Kaur P, Sharma S, & Singh TP (2013) Structural insights into the dual strategy of recognition by peptidoglycan recognition protein, PGRP-S: Structure of the ternary complex of PGRP-S with lipopolysaccharide and stearic acid. Plos One. 8(1):e53756. doi: 10.1371.

Sharma P, Yamini S, Dube D, Singh A, Mal G, Pandey N, Sinha M, Singh AK, Dey S, Kaur P, Mitra DK, Sharma S, & Singh TP (2013) Structural Basis of the Binding of Fatty Acids to Peptidoglycan Recognition Protein, PGRP-S. Arch Biochem Biophys. 529(1):1-10. doi: 10.1016.

Sharma P, Dube D, Sinha M, Dey S, Kaur P, Sharma S,& Singh TP (2012) Structural basis of heparin binding to camel peptidoglycan recognition protein-S. Int J Biochem Mol Biol. 3:86-94.

Sharma P, Dube D, Sinha M, Mishra B, Dey S, Mal G, Pathak KML, Kaur P, Mitra DK, Sharma S, & Singh TP (2011) Multi-ligand specificity of pathogen associated molecular pattern-binding site in peptidoglycan recognition protein. J Biol Chem 286:31723-30.

Sharma P, Dube D, Singh A, Mishra B, Singh N, Sinha M, Dey S, Kaur P, Mitra DK, Sharma S, & Singh TP (2011) Structural basis of recognition of pathogen associated molecular patterns and inhibition of proinflammatory cytokines by camel peptidoglycanrecognition protein. J Biol Chem 286, 16208-17.

Sharma P, Singh N, Sinha M, Sharma S, Perbandt M, Betzel C, Kaur P, Srinivasan A & Singh TP (2009) Tryptophan as a three-way switch in regulating the function of the secretory signalling glycoprotein (SPS-40) from mammary glands: structure of SPS-40 complexed with 2-methylpentane-2,4-diol at 1.6 Å resolution. Acta Cryst D 65, 375-8.

Sharma P, Singh N, Sinha M, Sharma S, Perbandt M, Betzel C, Kaur P, Srinivasan A & Singh TP (2008) Crystal structure of the peptidoglycan recognition protein at 1.8 Å resolution reveals dual strategy to combat infection through two independent functional homodimers. J Mol Biol 378, 923-32.    

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