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अखिल भारतीय आयुर्विज्ञान संस्थान, नई दिल्ली
All India Institute Of Medical Sciences, New Delhi

Dr Mayank Singh

Name - Dr Mayank Singh

Designation- Associate Professor

Department- Medical Oncology (Lab) Dr BRAIRCH AIIMS New Delhi

Contact Information

Address- Department of Medical Oncology (Lab) Room no 411, 4th Dr B.R.A.I.R.C.H AIIMS Ansari Nagar, New Delhi 110029

Email-   This email address is being protected from spambots. You need JavaScript enabled to view it. , This email address is being protected from spambots. You need JavaScript enabled to view it.

 

Area of Expertise-

  • Immunotherapy and its application in Cancer therapeutics.

  • Ubiquitin/Deubiquitin signaling and its application in cancer therapeutics.

  • Role of Histone Acetyl Transferases in inducing epigenetic modification in cancer microenvironment and its application in cancer and cancer stem cell Biology.

  • Liquid Biopsy and its application as a diagnostic tool.



Research Experience-

  • Assistant Professor Medical Oncology (Lab) Dr BRAIRCH AIIMS Delhi (2017-2020)

  • Senior Post doctorate researcher associate at Department of Radiation oncology, Comprehensive cancer center Ohio state university Columbus Ohio (2015-2017)

  • Post doctorate research associate at Cleveland clinic Lerner Research Institute Cleveland Ohio United states (2015)

  • Postdoctoral Research Associate at UTSW (University of Texas South Western) Medical Center in Dallas Texas USA (2009-2012)

  • Postdoctoral Research Associate at Penn state Herhey Medical center, Hershey   Pennsylvania USA (2009)



Awards-

  • American Association for Cancer Research (AACR) Avon foundation Scholar in training Awardee at AACR 100th Annual Meeting, Denver ,Colorado 2009.

  • American association for cancer research (AACR) Scholar in training Awardee at AACR Translational Cancer Medicine 2008, Monterey CA, July 2008.

  • American Association for Cancer Research (AACR) Avon foundation Scholar in training Awardee at AACR special conference Advances in cancer research from laboratory to clinic Dead Sea, Jordan, March 2008.

  • Awarded CSIR NET SRF fellowship from Council of scientific and industrial research (CSIR) (2006-2009).

  • Awarded CSIR NET JRF fellowship from Council of scientific and industrial research (CSIR) (2004-2006).

  • Awarded GATE fellowship from Govt of India (2003).



Ongoing grants (Extramural and Intramural) sanctioned as PI (03)

 







Completed Project as PI (01)

 

S. No.

Title of the project

Funding agency

Duration (years)

1

Validation of USP37 as a prognostic

and diagnostic marker in Osteosarcoma

AIIMS

2

 

Selected Publications

 

  1. Stromberg BR, Singh M, Torres AE, Burrows AC, Pal D, Insinna C, Rhee Y, Dickson AS, Westlake CJ, Summers MK. The deubiquitinating enzyme USP37 enhances CHK1 activity to promote the cellular response to replication stress. J Biol Chem. 2021 Sep 10;297(4):101184. doi: 10.1016/j.jbc.2021.101184. Epub ahead of print. PMID: 34509474; PMCID: PMC8487067. (Shared First Authorship)



  1. Sharma A, Singh M, Chauhan R, Malik PS, Khurana S, Mathur S, Kumar S, Sreenivas V, Kumar L. Pazopanib based oral metronomic therapy for platinum resistant/refractory epithelial ovarian cancer: A phase II, open label, randomized, controlled trial. Gynecol Oncol. 2021 Aug;162(2):382-388. doi: 10.1016/j.ygyno.2021.05.025. Epub 2021 Jun 2. PMID: 34088513.



  1. Singh M, Prasad CP, Shankar A. Publication Charges Associated with Quality Open Access (OA) Publishing and Its Impact on Low Middle Income Countries (LMICs), Time to Reframe Research Policies. Asian Pac J Cancer Prev. 2021 Sep 1;22(9):2743-2747. doi: 10.31557/APJCP.2021.22.9.2743. PMID: 34582641. (Corresponding author)



  1. Nisar S, Yousuf P, Masoodi T, Wani NA, Hashem S, Singh M, Sageena G, Mishra D, Kumar R, Haris M, Bhat AA, Macha MA. Chemokine-Cytokine Networks in the Head and Neck Tumor Microenvironment. Int J Mol Sci. 2021 Apr 27;22(9):4584. doi: 10.3390/ijms22094584. PMID: 33925575; PMCID: PMC8123862.



  1. Lone SN, Bhat AA, Wani NA, Karedath T, Hashem S, Nisar S, Singh M, Bagga P, Das BC, Bedognetti D, Reddy R, Frenneaux MP, El-Rifai W, Siddiqi MA, Haris M, Macha MA. miRNAs as novel immunoregulators in cancer. Semin Cell Dev Biol. 2021 Apr 26:S1084-9521(21)00086-0. doi: 10.1016/j.semcdb.2021.04.013 PMID: 33926791.



  1. Nisar S, Bhat AA, Singh M, Karedath T, Rizwan A, Hashem S, Bagga P, Reddy R, Jamal F, Uddin S, Chand G, Bedognetti D, El-Rifai W, Frenneaux MP, Macha MA, Ahmed I and Haris M (2021) Insights Into the Role of CircRNAs: Biogenesis, Characterization, Functional, and Clinical Impact in Human Malignancies. Front. Cell Dev. Biol. 9:617281. doi: 10.3389/fcell.2021.617281 (Shared First Authorship)



  1. Cytokine-Chemokine Network Driven Metastasis in Esophageal Cancer; Promising Avenue for Targeted Therapy. Ajaz Ahmad Bhat, Sabah Nisar, Selma Maacha, Tatiana Carneiro-Lobo, Sabah Akhtar, Kodappully Sivaraman Siveen, Nisar Ahmad Wani, Arshi Rizwan, Puneet Bagga, Mayank Singh, Ravinder Reddy, Shahab Uddin, Jean-Charles Grivel, Gyan Chand, Michael P Frenneaux, Mushtaq A Siddiqi, Davide Bedognetti, Wael El-Rifai, Muzafar A. Macha, Mohammad Haris, Mol Cancer. 2021 Jan 4;20(1):2. doi: 10.1186/s12943-020-01294-3.



  1. Non-invasive biomarkers for monitoring the immunotherapeutic response to cancer. Sabah Nisar, Ajaz Ahmad Bhat, Sheema Hashem, Santosh Kumar Yadav, Arshi Rizwan, Mayank Singh, Puneet Bagga, Muzafar A Macha, Michael P Frenneaux, Ravinder Reddy, Mohammad Haris, J Transl Med. 2020 Dec 9;18(1):471. doi: 10.1186/s12967-020-02656-7.



  1. Histone Acetyltransferase MOF Orchestrates Outcomes at the Crossroad of Oncogenesis, DNA Damage Response, Proliferation, and Stem Cell Development. Mayank Singh, Albino Bacolla, Shilpi Chaudhary, Clayton R. Hunt, Shruti Pandita, Ravi Chauhan, Ashna Gupta, John A. Tainer, Tej K. Pandita. Molecular and Cellular Biology Aug 2020, 40 (18) e00232-20; DOI: 10.1128/MCB.00232-20 (Corresponding author)



  1. The Therapeutic and Preventive Efficacy of Curcumin and Its Derivatives in Esophageal Cancer. Komal Komal, Shilpi Chaudhary, Preeti Yadav, Raja Parmanik, Mayank Singh.Asian Pac J Cancer Prev. 2019 May 25;20(5):1329-1337. (Corresponding Author)



  1. Environmental and occupational determinants of lung cancer. Abhishek Shankar, Anusha Dubey, Deepak Saini, Mayank Singh, Chandra Prakash Prasad, Shubham Roy, Sachidanand Jee Bharati, Minakshi Rinki, Navneet Singh, Tulika Seth, Meghal Khanna,Niharika Sethi, Sunil Kumar, Bhawna Sirohi, Anant Mohan, Randeep Guleria, Goura Kishor Rath. Transl Lung Cancer Res 2019;8(Suppl 1):S31-S49

 

  1. Shankar A, Saini D, Dubey A, Roy S, Bharati SJ, Singh N, Khanna M, Prasad CP, Singh M, Kumar S, Sirohi B, Seth T, Rinki M, Mohan A, Guleria R, Rath GK. Feasibility of lung cancer screening in developing countries: challenges, opportunities and way forward. Transl Lung Cancer Res 2019;8(Suppl 1):S106-S121. doi: 10.21037/tlcr.2019.03.03



  1. Cancer research in India: Challenges & opportunities. M Singh, CP Prasad, TD Singh, L Kumar. Indian J Med Res. 2018 Oct;148(4):362-365.



  1. Targeting Inflammation in Ovarian Cancer Through Natural Antioxidants, Potential Therapeutic and Preventive Implications. M Singh, A Shankar, KS Dhiman, R Kotecha, GK Rath. Asian Pac J Cancer Prev. 2018 Oct 26;19(10):2687-2690.



  1. MOF suppresses replication stress and contribute to resolution of stalled replication forks. Singh DK, Pandita RK, Singh M, Chakraborty S, Hambarde S, Ramnarain D, Charaka V, Ahmed KM, Hunt CR, Pandita TK. Mol Cell Biol. 2018 Jan 3. pii: MCB.00484-17. doi: 10.1128/MCB.00484-17.



  1. MOF phosphorylation by ATM regulates 53BP1-mediated DSB repair pathway choice. Arun Gupta, Clayton R. Hunt, Muralidhar L. Hegde, Sharmistha Chakraborty, Durga Udayakumar, Nobuo Horikoshi, Mayank Singh, Deepti B. Ramnarain, Walter N. Hittelman, Sarita Namjoshi, Aroumougame Asaithamby, Tapas K. Hazra, Thomas Ludwig, Raj K. Pandita, Jessica K. Tyler, and Tej K. Pandita. Cell Reports (cell press). 2014 Jul 10;8(1):177-89. doi: 10.1016/j.celrep.2014.05.044. Epub 2014 Jun 19.



  1. Lamin A/C Depletion Enhances DNA Damage-Induced Stalled Replication Fork Arrest. Mayank Singh, Clayton R. Hunt, Raj K. Pandita, Rakesh Kumar, Chin-Rang Yang, Nobuo Horikoshi, Robert Bachoo, Sara Sarag, Michael D. Story, Jerry W. Shay, Simon N. Powell, Arun Gupta, Jessie Jeffery, Shruti Pandita, Benjamin P. C. Chen, Dorothee Deckbar, Markus, Qin Yang, Kum Kum Khanna, Howard J. Worman, Tej K. Pandita. Molecular and Cellular Biology. 2013 Mar;33(6):1210-22. doi: 10.1128/MCB.01676-12. Epub 2013 Jan 14.

 

  1. T-cell-specific deletion of Mof blocks their differentiation and results in genomic instability in mice. Gupta A, Hunt CR, Pandita RK, Pae J, Komal komal , Singh M, Shay JW, Kumar R, Ariizumi K, Horikoshi N, Hittelman WN, Guha C, Ludwig T, Pandita TK. Mutagenesis. 2013 May; 28(3):263-70.

 



  1. Human exonuclease 5 is a novel sliding exonuclease required for genome stability. Sparks JL, Kumar R, Mayank Singh, Wold MS, Pandita TK,Burgers PM. Journal of Biological Chemistry. 2012 Dec 14;287(51):42773-83.



  1. Chromatin modifications and the DNA damage response to ionizing radiation. Kumar R, Horikoshi N, Mayank Singh, Gupta A, Misra HS, Albuquerque K, Hunt CR, Pandita TK. Frontiers in Oncology. 2012;2:214.



  1. Bhadra MP, Horikoshi N, Pushpavallipvalli SN, Sarkar A, Bag I, Krishnan A, Lucchesi JC, Kumar R, Yang Q, Pandita RK, Singh M, Bhadra U, Eissenberg JC, Pandita TK. The role of MOF in the ionizing radiation response is conserved in Drosophila melanogaster. Chromosoma. 2011 Nov 10.ISSN : 0009-5915

  2. SinghM,SinghNCurcumincounteractstheproliferativeeffectofestradiolinhumancervicalcarcinomacell lines. Molecular and Cellular Biochemistry, 2011 Jan;347(1-2):1-11. ISSN: 0300-8177.

 

  1. Singh M, Singh N Molecular mechanism of curcumin induced cytotoxicityin cervical carcinoma cell lines. Molecular and Cellular Biochemistry,2009 May;325(1-2):107-19. ISSN: 0300-8177

 

  1. Singh M, Singh N Induction of apoptosis byhydrogen peroxide in HPV 16 positive human cervical cancer cells: involvement ofmitochondrial pathway. Molecular and Cellular Biochemistry, 310: 57-65, 2008. ISSN: 0300-8177

 

  1. Singh M, Sharma H, Singh N. Hydrogen peroxide induces apoptosis in HeLa cells through mitochondrial pathway. Mitochondrion,7: 367-373, 2007.ISSN: 1567-7249

 

 

Orc id: https://orcid.org/0000-0003-0728-1936

Links

Google Scholar- https://scholar.google.co.in/citations?user=5odRRS4AAAAJ&hl=en

Pub Medhttps://www.ncbi.nlm.nih.gov/pubmed/?term=mayank+singh

Research Gate- https://www.researchgate.net/profile/Mayank_Singh32/publications

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