Prof. (Dr.) Kameshwar Prasad
MD, DM, MMSc, FRCP(Edin), FAMS
Head, Department of Neurology and Stroke Unit;
Chief, Neurosciences Centre & Director of Clinical Epidemiology,
All India Institute of Medical Sciences (AIIMS), New Delhi, India
Room No. 702, 7th Floor, Neurosciences Centre, AIIMS.
Phone (Office): +91 11 26594856; Fax: +91 11 26588663
OPD days: Tuesdays and Fridays
(For OPD appointments call: +91 11 26594656 or office)
Special Interests: Stroke, Vascular Dementia, Multiple Sclerosis, Stem Cells, Meningitis, Evidence-Based Medicine, Research Methodology
Dr. Kameshwar Prasad is Professor and Head of the Department of Neurology at All India Institute of Medical Sciences (AIIMS), New Delhi, India. He has more than 35 years of clinical, teaching and research experience and has published more than 270 papers (>125 in Stroke) in peer reviewed journals of national and international repute.
Dr. Prasad has been invited more than 30 times to teach in several international universities including Oxford (3 times), McMaster University, Canada (>10 times), National University, Singapore (7 times), Arabian Gulf University (10 times) and many others across India and the globe. He is a member of the World Stroke Organization Global Quality and Guidelines Working Group. He is also Editor and Reviewer of the International Cochrane Collaborative Stroke Review Group based in Edinburgh, UK.
The British Medical Journal invited him to be an editorial board member and the Chicago-based ‘Year Book’, American College of Physicians Journal, and Oxford-based journals have graded his research papers as high-quality and relevant with five- and six-star impact ratings.
He is Principal Investigator of the first of its kind Cohort study in India entitled “A population-based cohort study to unravel the causes of stroke and cognitive decline” in collaboration with the Rotterdam Study Group, Erasmus MC, The Netherlands. Under UK-India Education & Research Initiative, he has established the largest blood bio-repository of stroke in India, in collaboration with Imperial College, London, UK. He has been the national Coordinator of many International Stroke Trials viz. IST, STICH, ENOS etc. His Cochrane review of Surgery in Intracerebral hemorrhage was first to establish the role of surgery in the condition.
Dr. Prasad has been a member of the International Advisory Committee, Asia Pacific Forum for Quality improvement in Healthcare; Editorial Group of ‘Practical Neurology’ – a British Medical Journal publication; Editorial Group, Cochrane ARI Review Group, Australia; Infectious Diseases and ARI Review Group of International Cochrane Collaboration; and International Clinical Epidemiology Network. Dr. Prasad is member of the Editorial Board of several national and international journals including British Medical Journal, Practical Neurology etc. Dr. Prasad is also a referee for many national & international journals and organizations including British Medical Journal, Medical Research Council-UK, Wellcome Trust, Cochrane, Lancet Neurology, Stroke and many others.
Dr Prasad started Stroke clinic in 1995 and established the Stroke unit since its inception in 2001 at AIIMS, New Delhi. He has been associated with the Indian National Programme for Control and Prevention of Stroke since its inception. He has been a member of the core committee, technical advisory committee and various expert groups to the national programme and continues to be a member of its expert group. He is Chairman of the Scientific Advisory Board, Panel Area for Stroke Registry, Indian Council of Medical Research, and has been the Convenor of the National Stroke Management Guidelines (India).
Dr. Prasad coordinated the first multicentric national randomized study of role of bone marrow derived stem cell therapy in stroke, which is first of its kind study at global level published in the American Stroke Association Journal ‘Stroke’. He has also conducted a research trial on Mobilization of Stem Cells Using G-CSF for Acute Ischemic Stroke published in international journal “Stroke Research & Treatment”. He is also coordinating a project in which role of biomarkers for the prediction of stroke recovery is being studied. He has been the principal investigator of several stem cell studies in stroke model and genetics of stroke funded by Government of India.
Dr. Prasad has also made outstanding contributions in the field of Evidence-Based Medicine (EBM). He has been associated with EBM since its inception 1992. He has received master degree in health research methodology and clinical epidemiology with emphasis on EBM from the McMaster University, Canada in 1993. He has worked with and is part of the First (pioneer) International Working Group on EBM established at McMaster. He has contributed three chapters as a co-author in the world famous JAMA (Journal of American Medical Association) Book on “Users’ Guide to Medical Literature” published by McGraw-Hill. He has conducted several workshops on Research Methodology and Evidence Based Medicine in India and abroad. He is the founding Secretary of the International Society for Evidence-Based Health care. He is also Chairman of the research methodology courses for UG/PG students being conducted at AIIMS, New Delhi.
He has authored a book “Fundamentals of Evidence-Based Medicine”, which has been reviewed as the best recommended book in the field by the Journal of American Medical Association in December 2006. He has been the Editor-in-Chief of “Bickerstaff’s Neurological Examination in Clinical Practice”, 7th edn. He has also authored a Book on Stem Cell in Hindi titled “Stem Cell – Sankshep me sabhi aavashyak jaankari” for general public.
Dr. Prasad is a Fellow of Royal College of Physicians (Edinburgh), Fellow of National Academy of Medical Sciences (India), and Editor of Edinburgh-based Cochrane Stroke Group. He has also received several awards and honours from national and international organizations including the prestigious civilian honour “Padmashree” from the President of India.
He has also been Chief Guide to several UG/PG and Ph.D. students (currently 8). Presently, he is working in the area of Stem Cell transplantation in Multiple sclerosis and Stroke.
1.The International Stroke Trial (IST): a randomised trial of aspirin, subcutaneous heparin, both, or neither among 19435 patients with acute ischaemic stroke. International Stroke Trial Collaborative Group. Lancet. 1997 May 31;349(9065):1569-81. (cited by 916)
2.van de Beek D, de Gans J, McIntyre P, Prasad K. Corticosteroids for acute bacterial meningitis. Cochrane Database Syst Rev 2007;24:CD004405. (cited by 154)
3.van de Beek D, de Gans J, McIntyre P, Prasad KSteroids in adults with acute bacterial meningitis: a systematic review. Lancet Infect Dis. 2004 Mar;4(3):139-43. (cited by 106)
4.Prasad K, Singh M. Corticosteroids for managing tuberculous meningitis. Cochrane Database Syst Rev. 2008 23;(1):CD002244.PMID: 18254003. (cited by 77)
5.Ahuja GK, Mohan KK, Prasad K, Behari M. Diagnostic criteria for tuberculous meningitis and their validation. Tubercle and Lung Disease 1994;75: 149-152. (cited by 69)
6.Prasad K. The Glasgow Coma Scale : A critical appraisal of its clinimetric properties. J ClinEpid 1996: 49: 755-763. (cited by 47)
7.Ahuja GK, Behari M, Prasad K, Goulatia RK, Jailkhani B. Disappearing CT Lesions in epilepsy: Is tuberculosis or cysticercosis the cause? J NeurolNeurosurgPsy 1989;52:915‑916.(cited by 44)
8.Prasad K, Al-Roomi K, Krishnan PR, Sequeira R. Anticonvulsant therapy for status epilepticus. Cochrane Database Syst Rev 2005;CD003723. (cited by 43)
9.Hamdy H, Prasad K, Anderson MB, Scherpbier A, Williams R, Zwierstra R, Cuddihy H. BEME systematic review: predictive values of measurements obtained in medical schools and future performance in medical practice. Med Teach 2006;28:103-16. (cited by 40)
10.Marais S, Thwaites G, Schoeman JF, Török ME, Misra UK, Prasad K, Donald PR, Wilkinson RJ, Marais BJ. Tuberculous meningitis: a uniform case definition for use in clinical research. Lancet Infect Dis. 2010;10:803-12.(cited by 34)
11.Prasad K, Browman G, Shrivastava A, Menon Geetha. Surgery in primary supratentorialintracerebral hematoma: a meta-analysis of randomised trials. ActaNeurologicaScandinavica 1997;95:103-110. (cited by 32)
12.Kumarvelu S, Prasad K, Khosla A, Behari M, Ahuja GK. Randomized controlled trial of dexamethasone in tuberculous meningitis. Tubercle and Lung Disease 1994;75: 203-207. (cited by 26)
13.Prasad K, Mendelow AD, Gregson B. Surgery for primary supratentorialintracerebralhaemorrhage. Cochrane Database Syst Rev. 2008 Oct 8;(cited by 4):CD000200. Review. (cited by 24)
14.Salinas R, Counsell C, Prasad K, Gelband H, Garner P. Treating neurocysticercosis: a systematic review of randomized, controlled trials. Tropical Medicine and International Health 1999;4:713-718. (cited by 23)
15.Singh RR, Prasad K, Kumar A, Mishra A, Padam Kumar R, Malviya AN. Cerebellar ataxia in systemic lupus erythematosus: Three case reports Ann Rh Dis 1988;47:954‑956. (cited by 23)
16.SrivastavaAK, Prasad K. A study of factors delaying hospital arrival of patients with acute stroke. NeurolIndia. 2001;49:272-6. (cited by 22)
17.Padma MV, SinghMB, Bhatia R, Srivastava A, Tripathi M, Shukla G, Goyal V, Singh S, Prasad K, Behari M. Hyperacute thrombolysis with IV rtPA of acute ischemic stroke: Efficacy and safety profile of 54 patients at a tertiary referral center in a developing country. Neurol India 2007;55:46-9. (cited by 21)
18.Hamdy H, Prasad K, Williams R, Qader F. Reliability and validity of the Direct Observation Clinical Encounter Examination. Medical Education 2003;37:205-12. (cited by 18)
19.Luthra K., Prasad K, Kumar P., Dwivedi M., Pandey R., Das N. Apolipoprotein E gene polymorphism in cerebrovascular disease: a case-control study. Clin. Genet. 2002;62:39-44. (cited by 18)
20.Prasad K, Haines T. Dexamethasone therapy in acute bacterial meningitis: how strong is the evidence for routine use? J NeurolNeurosurg Psych 1995;59: 31-37 in the 1997 Year Book of Infectious Diseases. (cited by 16)
21.Prasad K, Krishnan PR, Al-Roomi K, Sequeira R. Anticonvulsant Therapy for Status Epilepticus. Br J ClinPharmacol. 2007;63(cited by 6):640-7. (cited by 15)
22.Srivastava AK, Khanna N. Sardana V., Gaekwad S., Prasad K., Behari M. Cerebral venous thrombosis in ulcerative colitis. NeurolIndia. 2002;50:215-7. (cited by 15)
23.Tripathi M, Vibha D, Choudhary N, Prasad K, Srivastava MV, Bhatia R, Chandra SP. Management of refractory status epilepticus at a tertiary care centre in a developing country. Seizure. 2010;19:109-11. (cited by 12)
1.Prasad K, Sharma A, Garg A, Mohanty S, Bhatnagar S, Johri S, Singh KK, Nair V, Sarkar RS, Gorthi SP, Hassan KM, Prabhakar S, Marwaha N, Khandelwal N, Misra UK, Kalita J, Nityanand S; for InveST Study Group. Intravenous autologous bone marrow mononuclear stem cell therapy for ischemic stroke: a multicentric, randomized trial. Stroke. 2014;45(12):3618-24.
2.Raj K, Bhatia R, Prasad K, Padma Srivastava MV, Vishnubhatla S, Singh MB. Seasonal differences and circadian variation in stroke occurrence and stroke subtypes. J Stroke Cerebrovasc Dis. 2015;24:10-6.
3.Alper BS, Malone-Moses M, McLellan JS, Prasad K, Manheimer E. Thrombolysis in acute ischaemic stroke: time for a rethink? BMJ. 2015 Mar 17;350:h1075.
4.Kumar A, Prasad M, Kathuria P, Nair P, Pandit AK, Sahu JK, Prasad K. Low Socioeconomic Status is an Independent Risk Factor for Ischemic Stroke: A Case-Control Study in North Indian Population. Neuroepidemiology. 2015;44(3):138-143.
5.Kumar A, Pandit AK, Vivekanandhan S, Srivastava MV, Tripathi M, Prasad K. Association between beta-1 adrenergic receptor gene polymorphism and ischemic stroke in North Indian population: A case control study. J Neurol Sci. 2015 Jan 15;348(1-2):201-5.
6.ENOS Trial Investigators, Bath PM, Woodhouse L, Scutt P, Krishnan K, Wardlaw JM, Bereczki D, Sprigg N, Berge E, Beridze M, Caso V, Chen C, Christensen H, Collins R, El Etribi A, Laska AC, Lees KR, Ozturk S, Phillips S, Pocock S, de Silva HA, Szatmari S, Utton S. Efficacy of nitric oxide, with or without continuing antihypertensive treatment, for management of high blood pressure in acute stroke (ENOS): a partial-factorial randomised controlled trial. Lancet. 2015 Feb 14;385(9968):617-28.
7.Sharma A, Prasad K, Padma MV, Tripathi M, Bhatia R, Singh MB, Sharma A. Prevalence of triggering factors in acute stroke: hospital-based observational cross-sectional study. J Stroke Cerebrovasc Dis. 2015 Feb;24(2):337-47.
8.Raj K, Bhatia R, Prasad K, Srivastava MV, Vishnubhatla S, Singh MB. Seasonal differences and circadian variation in stroke occurrence and stroke subtypes. J Stroke Cerebrovasc Dis. 2015 Jan;24(1):10-6.
9.Sharma A, Prasad K, Padma MV, Tripathi M, Bhatia R, Singh MB, Sharma A. Prevalence of Triggering Factors in Acute Stroke: Hospital-Based Observational Cross-sectional Study. J Stroke Cerebrovasc Dis. 2014 Nov 22. pii: S1052-3057(14)00437-6.
10.Dash D, Bhashin A, Pandit AK, Tripathi M, Bhatia R, Prasad K, Padma MV. Risk factors and etiologies of ischemic strokes in young patients: a tertiary hospital study in north India. J Stroke. 2014 Sep;16(3):173-7.
11.ENOS Investigators. Baseline characteristics of the 4011 patients recruited into the ‘Efficacy of Nitric Oxide in Stroke’ (ENOS) trial. Int J Stroke. 2014;9(6):711-20.
12.Karlupia N, Manley NC, Prasad K, Schäfer R, Steinberg GK. Intra-arterial transplantation of human umbilical cord blood mononuclear cells is more efficacious and safer compared with umbilical cord mesenchymal stromal cells in a rodent stroke model. Stem Cell Res Ther. 2014;5:45.
13.Rai VK, Bhatia R, Prasad K, Padma Srivastava MV, Singh S, Rai N, Suri A. Long-term outcome of decompressive hemicraniectomy in patients with malignant middle cerebral artery infarction: a prospective observational study. Neurol India. 2014;62:26-31.
14.Kumar A, Prasad K, Tripathi M, Padma Srivastava MV, Vivekanadhan S. Association of genetic polymorphisms at beta-adrenergic receptor with risk of intracerebral hemorrhagic stroke in North Indian population: a case control study. Neurol India. 2014;62:183-8.
15.Gupta P, Prasad K, Kumar A, Kumar P, Bhatia R, Tripathi M. Clinical predictors and outcome of patients of acute stroke requiring ventilatory support: a prospective hospital based cohort study. J Neurol Sci. 2014;337:14-7.
16.Murad MH, Montori VM, Ioannidis JP, Jaeschke R, Devereaux PJ, Prasad K, Neumann I, Carrasco-Labra A, Agoritsas T, Hatala R, Meade MO, Wyer P, Cook DJ, Guyatt G. How to read a systematic review and meta-analysis and apply the results to patient care: users' guides to the medical literature. JAMA 2014;312:171-9.
17.Kumar A, Tripathi M, Srivastava MV, Vivekanandhan S, Prasad K. Relationship between polymorphisms in beta -2 adrenergic receptor gene and ischemic stroke in North Indian Population: a hospital based case control study. BMC Res Notes 2014;7:396.
18.Kumar A, Vivekanandhan S, Srivastava A, Tripathi M, Padma Srivastava MV, Saini N, Kumar P, Prasad K. Association between angiotensin converting enzyme gene insertion/deletion polymorphism and ischemic stroke in north Indian population: a case-control study and meta-analysis. Neurol Res. 2014 Feb 12:1743132814Y0000000335. [Epub ahead of print].