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अखिल भारतीय आयुर्विज्ञान संस्थान, नई दिल्ली
All India Institute Of Medical Sciences, New Delhi

Dr. Shyam S. Chauhan

 

From left to right: Mr Iqbal, Mr Manoj, Mr Siddharth, Mr Vikas, Dr Anurag, Ms Prerana, Dr Mansi, Ms Garima, Dr Fatima, Dr Vinod, Dr Prajwal, in centre Prof S S Chauhan

 

Address:  Room No 3012, Teaching block,
                Department of Biochemistry,
                All India Institute of Medical Sciences
                Ansari Nagar, New Delhi-110029

Phone: 26589617; 26594483; 26593272

Email id: This email address is being protected from spambots. You need JavaScript enabled to view it.

 

Academic Details:

Degree

Subject

University/ Institution

Year

B.Sc.

Chemistry, Botany, Zoology

University of Delhi

1979

M.Sc.

Biochemistry

Kurukshetra University

1982

Ph.D.

Medical Biochemistry

V.P. Chest Institute, University of Delhi

1988

Positions held:

Position

Department

University/ Institution

Dates

Postdoctoral Fellow

Department of
Biochemistry & Biophysics

University of Pennsylvania, School of Medicine, Philadelphia, PA, USA

May 11, 1987 to December 15, 1988.

Visiting Fellow

Laboratory of Molecular Biology

National Cancer Institute,
NIH, Bethesda, MD, USA

 

December 16, 1988 to March 31, 1990.

Visiting Associate

Laboratory of Cell Biology

National Cancer Institute,
NIH, Bethesda, MD, USA

April 1990-May 26, 1992.

Assistant Professor

Department of Biochemistry

All India Institute of Medical Sciences, New Delhi-110029

May1992- July 1996

Associate Professor

Department of Biochemistry

All India Institute of Medical Sciences, New Delhi-110029

July1996- July 2000

Additional Professor

Department of Biochemistry

All India Institute of Medical Sciences, New Delhi-110029

July 2000- Sept. 2005

Professor

Department of Biochemistry

All India Institute of Medical Sciences, New Delhi-110029

Sept. 2005- Jan.2016

Professor and Head

Department of Biochemistry

All India Institute of Medical Sciences, New Delhi-110029

Feb.2016- till date

 

Notable Awards and Society Memberships

1.    Delivered Prof. T.N. Pattabhiraman Oration 2015, during 42nd Annual meeting of Association of Clinical Biochemists of India held from November 25-27, 2015 at Postgraduate Institute of Medical Education and Research, Chandigarh.

2.    Delivered Mrs. and Dr. G.P. Talwar Oration in 31st National Annual Conference of Association of Clinical Biochemists of India held from December 1-4, 2004 at Belgaum.

3.   Awarded Fogarty International Research Fellowship to work as a visiting scientist at National Cancer Institute, NIH, Bethesda, MD, USA, (September 1999-October, 2000).

4.    Awarded Federation of Immunological Societies of Asia-Oceania (FIMA) bursary ($1000) for attending Advanced Immunology Training Course Cum Symposium held   at Beijing, China from October20-25, 1996.

 

Membership of Professional bodies:

  • Association of Clinical Biochemists of India - Life Member
  • Society of Biological Chemists (India) - Life Member
  • Indian Association for Cancer Research - Life Member
  • Indian Immunology Society - Life Member
  • International Society for Heart Research (Indian Section) - Life Member

 

Research Focus of the Lab:

Cathepsins, a heterogeneous group of lysosomal proteases are ubiquitously present in the nature. They are involved in physiological functions such as degradation and turnover of intracellular proteins, neo-vascularization, antigen presentation, pro hormone activation, sperm maturation, embryo implantation, cell growth and tissue homeostasis etc. These functions are altered in many pathological conditions including cancer and other ECM related pathologies. These proteases are overexpressed in malignancy and silencing their expression lead to:  impaired pro-hormone and pro-enzyme activation, immune defects, osteoporosis, epidermal hyperplasia, abnormal bone development and dilated cardiomyopathy. These observations underscore the importance of their controlled expression for various life processes. Therefore, the major focus of my laboratory is to understand the molecular mechanism(s) responsible regulation of these proteases particularly cathepsin L and B in several malignancies including gliomas, leukemia and gall bladder carcinoma with the objective of using it as a therapeutic target. Another major focus of our laboratory is to identify the biomarkers for early detection of gall bladder and oral cancer using high-throughput genomic and proteomic approach. We are also studying the molecular mechanism underlying the upregulation of RNA binding protein hnRNPD in the pathogenesis of oral cancer. PTEN mutations are preferentially found in human glioblastoma, with reported frequencies ranging from 15% to 40%. So there is an ongoing investigation in the lab to understand the clinical significance of PTEN regulated genes in human primary glioblastoma cells in relation to p53 status and understand their potential utility as prognostic markers and therapeutic targets.

 

List of Lab members

S.No.

Name

Post

1

Dr. Vinod Kumar

CSIR-Pool officer

2

Dr. Nishat Fatima

DST-women Scientist

3

Dr. Mansi Manchanda

Research Associate

4

Ms. Garima Pandey

PhD Student

5

Mr. SiddharthMehra

PhD Student

6

Ms.Prerna Jain

PhD Student

7

Mr. Anurag Kumar

MD Student

8

Mr. Prajwal A

MD Student

9

Mr. Vikas Kumar

Research Assistant

10

Mr. Manoj Kumar

Lab Attendant

11

Mr. Md. Iqbal

Lab Attendant

Positions Available: None

 

Key publications :

1.    Prajapati, S. C., Singh, R., and Chauhan, S. S.:  Human dipeptidyl peptidase III regulates G-protein coupled receptor-dependent Ca2+ concentration in human embryonic kidney 293T cells. Biological Chemistry. 397: 563-569, 2016.

2.    Kumar, M., Mehra, S., Thakar, A., Shukla, N.K., Roychoudhary, A., Sharma, M.C., Ralhan, R. and Chauhan, S.S.:End Binding 1 (EB1) overexpression in oral lesions and cancer: A biomarker of tumor progression and poor prognosis.Clin. Chim. Acta. 459:45-52, 2016.

3.    Chauhan, S.S., Kaur, J., Kumar, M., Matta, A., Srivastava, G., Alyass, A., Assi, J., Leong, I., MacMillan, C., Witterick, I., Colgan, T.J., Shukla, N.K., Thakar, A., Sharma, M.C., Siu, K.W., Walfish, P.G., and  Ralhan R.: Prognostic molecular signature for head and neck squamous cell carcinoma. Oncogenesis. 2015 Apr 20;4:e147. doi: 10.1038/oncsis.2015.7.

4.    Kumar, M., Srivastava, G., Kaur, J., Assi, J., Alyass, A., Leong, I., MacMillan, C., Witterick, I., Shukla, N.K., Thakar, A., Duggal, R., Roychoudhury, A., Sharma, M.C., Walfish, P.G., Chauhan, S.S. and  Ralhan R.: Prognostic significance of cytoplasmic S100A2 over expression in oral cancer patients.  J Transl. Med., 13: 8, 2015.

5.    Singh, R., Sharma, M.C., Sarkar, C., Singh, M. and Chauhan, S.S.: Transcription factor C/EBP-β mediates down regulation Dipeptidyl peptidase III by interleukin 6 in glioblastoma cells. FEBS J.281: 1629-1641, 2014.

6.    Samaiya, M., Bakhshi, S., Shukla, A.A., Kumar, L and Chauhan S.S.: Epigenetic regulation of cathepsin L expression in chronic myeloid leukemia. J. Cell. Mol. Med. 15: 2189-2199, 2011.

7.    Mir, R.A. and Chauhan S.S.: Down regulation of matrix degrading cysteine protease cathepsin L by acetaldehyde: role of C/EBP α PloS One 6(6): e20768, 2011

8.    Katara, R., Mir, R.A., Shukla, A.A., Singh, N. and Chauhan, S.S.: Wild type p53-dependent transcriptional up regulation of cathepsin L expression is mediated by C/EBPα in human glioblastoma cells. Biol. Chem., 39: 1031-1040, 2010.

9.    Shukla A. A. Jain M, Chauhan,S. S.: Ets-1/Elk-1 a critical mediator of   dipeptidyl peptidase-III transcription in human glioblastoma cells. FEBS J., 277: 1861-1875, 2010.

10.    Arora, S. and Chauhan, S.S.: Identification and characterization of a novel human   cathepsin L splice variant. Gene, 293: 123-131, 2002.

 

Research in my laboratory has been funded by DBT, DST, CSIR , DRDO  and Indo-Canadian research grants.

 

1.Dr. Vinod Kumar, Pool Scientist

He is currently working on “Investigation on B-Raf mutations in breast cancer”. Dr. Kumar has completed his DST Young Scientist project in my group before joining CSIR Pool Scientist. He is MSc Biotechnology from Punjabi University, Patiala and PhD from Jawaharlal Nehru University, New Delhi. He has Post Doctoral experience from International Centre for Genetic Engineering and Biotechnology, New Delhi and National Institute of Immunology, New Delhi.

 

2.Dr. Nishat Fatima (PhD Biotechnology), is currently working as a Scientist and Principal Investigator (DST-WOS-A) in the field of Epigenetics involved during cancer and other pathogenesis. Dr. Fatima has authored four International articles (one as a corresponding author), one WIPO publication (as an inventor), two book chapters, and also has a granted patent (both as an assignee and inventor). Her research experience is mainly in the area of epigenetics, reproductive biology, molecular biology, nano-drug delivery system, and translational research. She has post-doctoral experience as a Research Associate in Clinical Trial at Dr. R. M. L. Hospital, New Delhi along with other industrial experience.

 

3.Dr. Mansi Manchanda has recently completed her PhD and is now doing her postdoctoral training under my supervision. She is working on the “Regulation of cathepsin B and L by hepatotoxic agents”. Her research expertise and experience is in the area of molecular biology, hepatotoxicity and translational research.

 

4.Ms. Garima Pandey, final year PhD student (Senior research fellow, CSIR)

 She is currently working on the diagnostic/prognostic significance of cysteine cathepsins in pediatric acute myeloid leukemia (AML). She has completed her M.Sc. in Life Sciences from SLS, JNU, New Delhi.

 

5.Mr. Siddharth Mehra , Final year PhD student (Senior Research fellow, UGC)

Mr. SiddharthMehra has completed his M.Sc. in Biochemistry from All India Institute of Medical Sciences New Delhi in the year 2012. Currently he is a fourth year PhD student working on the Clinical significance of Cysteine Proteases in Human Gallbladder cancer.

 

6.Ms. Prerna Jain, PhD Scholar

She has completed her M.Sc in Department of Biochemistry, All India Institute of Medical sciences. She is registered PhD       student working on molecular mechanisms of differential regulation of cathepsin B in breast cancer cells with different metastatic potential.

 

7.Dr. Anurag Kumar, Junior Resident

He is a final year MD student. He has done his MBBS from MGIMS Wardha, Maharashtra. Currently he is working on glioma.

 

8.Mr. Vikas Kumar, completed his M.Sc. from our lab in 2016. He has done his B.Sc.(H) Biochemistry from Sri Venkateswara college, University of Delhi. Currently he is working on head and neck cancer.

 

9.Dr. Prajwal.A, Junior Resident

He is a 2nd year MD student. He has completed his MBBS from P.E.S institute of Medical Sciences and Research, Kuppam, Andhra pradesh. He is presently working on head and neck cancer.

 

10.Mr Manoj Kumar, Lab Attendant. He has been associated with the lab for last 8 years.

 

11.Mr Iqbal, Lab Attendant.  He has been associated with the lab for last 1 year.

 

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All India Institute of Medical Sciences

Ansari Nagar, New Delhi - 110029

Board Number : +91-11-26588500 / 26588700

Fax : +91-11-26588663 / 26588641

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