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अखिल भारतीय आयुर्विज्ञान संस्थान, नई दिल्ली
All India Institute Of Medical Sciences, New Delhi

Dr. Sudip Sen

 

 

Address: Room No. 3027A,

                Department of Biochemistry,

                AIIMS, New Delhi - 110029

Phone: +91-11-2659-4945

Email id: This email address is being protected from spambots. You need JavaScript enabled to view it.

Academic Details:

Degree

Subject

University/ Institution

Year

Ph.D.

Biochemistry

AIIMS, New Delhi

2007

M.D.

Biochemistry

AIIMS, New Delhi

2002

M.B.B.S.

  N.A.

N.R.S. Medical College, Calcutta

1995

 

Positions held:

Position

Department

University/ Institution

Dates

Assistant Professor

Biochemistry

AIIMS, New Delhi

2012 – till date

Assistant Professor

Biochemistry

UCMS, Delhi

2009 – 2012

DST Fast Track Fellow

Biochemistry & Ophthalmology

AIIMS, New Delhi

2006 – 2009

Research Associate

Biochemistry

AIIMS, New Delhi

2005 – 2006

Senior Resident

Biochemistry

AIIMS, New Delhi

2002 – 2005

 

Notable Awards and Society Memberships:

  1.         Member of National Academy of Medical Sciences (MNAMS) 2014.
  2. Member of

a)      International Society for Stem Cell Research (ISSCR)

b)     American Association for Cancer Research (AACR)

c)      European Association for Cancer Research (EACR)

d)     Indian Association for Cancer Research (IACR)

e)      Delhi Medical Association

  1. Awarded merit award for “Best 5 abstracts in Translational Regenerative Medicine submitted from India” out of top 20 abstracts from India and USA, for paper entitled “Ocular surface reconstruction using oral mucosal stem cells: from bench to bedside” at International Health Science Innovation Conference held at Mumbai, India from 15th to 17th January, 2015 organized by Ohio State University (USA) and AIIMS, New Delhi.
  2. Granted International Travel Award by European Society for Medical Oncology (ESMO) to attend the ESMO Congress, 2008 held at Stockholm, Sweden from 12th – 16th September, 2008. 
  3. Awarded International Travel Fellowship by the organizers (St. Gallen Oncology Conferences, UICC, ESMO, EACR, International Society for Cancer Chemoprevention) to attend the conference on “Cancer Prevention” held at St Gallen, Switzerland from 6th – 8th March, 2008.
  4. Geeta Mittal Medal awarded by All India Institute of Medical Sciences, New Delhi, India in October, 2007 for “The Best Basic Research in Oncology” and Geeta Mittal Book Prize for being “The Best postgraduate student in Basic Research in Oncology” for the year 2006 by AIIMS, New Delhi, India.
  5. International Development and Education Award (IDEA) along with Extended travel award (ETA) granted by the American Society of Clinical Oncology (ASCO) to attend the 43rd Annual meeting in Chicago, Illinois from June 1–5, 2007 and to attend the contact program for Translational Research at the Department of Medicine, University of Colorado Health Science Center (UCHSC) at Denver, Colorado, USA.  
  6. Scholar-in-Training Award granted by American Association for Cancer Research (AACR) and AFLAC at the First AACR International Conference on “Molecular Diagnostics in Cancer Therapeutic Development: Maximizing Opportunities for Individualized Treatment” held at Chicago, Illinois, USA from September 12 – 15, 2006.
  7. Awarded travel fellowship by the Scientific Committee, International Society for Cancer Chemoprevention and European Society of Medical Oncology (ESMO) to attend the conference on “Cancer Prevention” held at St Gallen, Switzerland from 16th-18th February, 2006.
  8. Awarded travel fellowship by UNESCO to participate in the Miami Nature Biotechnology Winter Symposium held at Miami, Florida, USA from 31st January to 4th February, 2004.
  9. Awarded travel fellowship by International Society for Cancer Chemoprevention to attend the conference on “Controversies in Tumor Prevention and Genetics” held at St. Gallen, Switzerland from 12th-14th February, 2004.
  10. Scholar-in-Training Award granted by American Association for Cancer Research (AACR) and AFLAC at the First Annual Frontiers in Cancer Prevention Research Conference held at Boston, Massachusetts, USA from October 14 – 18, 2002. 
  11. Geeta Mittal Medal and Book Prize awarded by All India Institute of Medical Sciences (AIIMS), New Delhi, India in April 2002 for being “The Best postgraduate student in the field of Clinical Research in Oncology” for the year 2001.

 

Research Focus of the Lab

We are trying to solve the following problems:          

a)      What are the various differences between cancer stem cells (CSC) and bulk tumor cells? Can we use this knowledge to identify / target these highly chemo- & radio-resistant cancer stem cells.

b)     Take cues from differentiation of mesenchymal stem cells (MSCs) as they differentiate into osteoblasts and use them to identify ways to target different cancers. Looking at ways to accelerate this differentiation process to improve bone healing.

c)      Try to develop an in-vitro model using stem cells to help identify ways to prevent & treat cerebral palsy.

 

List of Lab members

Dr. Sujata Pathak (Research Officer)

Dr. Priyanka Khare (DST-SERB National Post-doctoral fellow)

Ph.D. students:

  1. Dr. Amarpreet Kaur
  2. Ms. Aditi Bhattacharya
  3. Dr. Sandeep K. Agrawal
  4. Mr. DevanjanDey
  5. Dr. Janvie Manhas

M.D. students:

  1. Dr. Pradeep Jingar

Staff:

  1. Mr. Pramod Kumar (Lab attendant)
  2. Mr. Avdesh Kumar (Project staff)

Lab alumni:

  1. Dr. Sandeep K. Agrawal (MD student)
  2. Dr. Janvie Manhas (MD student)
  3. Ms. NupurKhera (MSc student)
  4. Ms. SumedhaSaluja (MSc student)

 

Positions Available: Currently, no positions are available.

 

Key publications:

  1. Manhas J, Bhattacharya A, Agrawal SK, Gupta B, Das P, Deo SV, Pal S, Sen S.  Characterization of cancer stem cells from different grades of human colorectal cancer. Tumour Biol, 2016 Aug 9. [Epub ahead of print] PubMed PMID: 27507615.
  2. Loying P, Manhas J, Sen S, Bose B. Autoregulation and heterogeneity in expression of human Cripto-1.  PLoS One, 2015; 10(2): e0116748.
  3. Sen S, Sharma S, Gupta A, Gupta N, Singh H, Roychoudhury A, Mohanty S, Sen S, Nag TC, Tandon R. Molecular characterization of explant cultured human oral mucosal epithelial cells. Invest Ophthalmol Vis Sci., 2011; 52(13): 9548-54.
  4. Sen S, Ateeq B, Sharma H, Datta P, Datta GuptaS, Bal S, Kumar A and Singh N.  Molecular profiling of genes in squamous cell lung carcinoma in Asian Indians.  Life Sciences, 2008; 82(13-14): 772-779.
  5. Kar R, Sen S, Singh A, Sharma H, Kumar S, Datta Gupta S and Singh N.  Role of apoptotic regulators in human epithelial ovarian cancer.  Cancer Biology and Therapy, 2007; 6 (7): 1101-1105. 

Thankful for intramural and extramural funding from various funding agencies.

 

1.Dr. Sandeep K Agrawal, MD, Senior Resident & PhD Scholar

Dr. Sandeep K Agrawal completed his MBBS from Gandhi Medical College, Bhopal in 2011 and MD in Biochemistry from AIIMS, New Delhi in 2015 and currently working as a Senior Resident and PhD Scholar. During his MD, Dr. Agrawal worked on the effect of Mycophenolate mofetil on mucin expression by oral mucosal epithelial cells, for its application as a graft material for corneal reconstruction by cultured oral mucosal epithelial transplantation (COMET) in patients of severe bilateral limbal stem cell deficiency. His current area of research includes elucidation of link between osteoblastic differentiation of human bone marrow derived mesenchymal stem cells and their tumorigenic potential. He is a life member of Association of Clinical Biochemists of India (ACBI) since 2014 and a member of Australian Society for Stem Cell Research (ASSCR) since 2015. He received international travel award from ASSCR in 2015 and Best Poster award in ACBICON, 2014.

2.Dr. Pradeep Jingar (MD Student)

 

Dr. Pradeep Jingar completed his MBBS from All India Institute of Medical Sciences, New Delhi in 2013. He has worked as Junior Resident in E.H.S (Dept. Of Family Medicine) for 5 months. He also had one year clinical experience as Junior Resident in the Dept. Of Geriatric Medicine, AIIMS New Delhi. He joined Department of Biochemistry in January 2015 as MD student. He is doing his MD Thesis under guidance of Dr. Sudip Sen. His current area of research is in Osteogenesis of Human Bone Marrow derived Mesenchymal Stem Cells (MSCs)

 

3.Ms. Aditi Bhattacharya- PhD student

Aditihas done her MSc. in Molecular Biology from Manipal University, Karnataka. During her dissertation, she studied the effects of nanoparticles in breast cancer cell lines. She has briefly worked in the Stem Cell Facility as a JRF, a part of CTVS of AIIMS, where she worked on cardiogenic differentiation of mesenchymal stem cells and also learnt in-vivo imaging of animals. Aditi is currently working as a PhD student (SRF) with Dr. Sudip Sen where she is characterizing and studying the gene Cripto-1 in colorectal cancer cell lines and also isolating and studying cancer stem cells in colorectal cancer tissue samples.

 

4.Dr. Janvie Manhas, MD - PhD Scholar

Dr. Janvie completed her M.D in Biochemistry from AIIMS, New Delhi and MBBS from Government Medical College, Srinagar. Her research aims to understand the biological mechanisms involved in metastasis and progression of colorectal cancer. Currently, she is analysing the role of cancer stem cells to find critical targets for clinical intervention in colorectal cancer using high throughput gene expression arrays. She has been awarded many national & international awards for her research work including the BoehringerIngelheimFonds (BIF) award, European association of cancer research (EACR) best poster presentation award, MOKAD Young Investigator Award, Proffered paper presentation and fellowship at the European cancer congress (ECC) 2015, Prof. L. M. Shrivastava Gold Medal Award for Best Oral Presentation.

 

Research publications:

  1. 1.      Characterisation of Cancer stem cells from different grades of human colorectal cancer.

J. Manhas, A. Bhattacharya, S.K. Agrawal, P. Das, S. Pal, SVS Deo, S. Sen.Tumor Biology, 2016. Manuscript in Press

2. Understanding aggressive colorectal cancer by gene expression analysis of cancer  stem cells. Abstract J. Manhas, A. Bhattacharya, S.K. Agrawal, M. Bhat, D. Ghosh, P. Das, S. Pal, SVS Deo, S. Sen. European Journal of Cancer, 2015, Issue 51, Page S1.

3. Autoregulation and heterogeneity in expression of Human Cripto-1

PojulLoying, Janvie Manhas, Sudip Sen, Biplab Bose. (Dec 2014), PLoS One.

 

5.Mr. Pramodkumar (Lab Attendant)

He is working as Medical Laboratory Attendant in Biochemistry Department since 1997. He has 19 years of experience in Research Lab. U.G Lab, Culture Lab, Radio Activity washing, Blood sampling patient care, I.R.Room equipment maintenance, Autoclaving, Baking, Cromic Acid making, currently handling Deparmently responsibility 

 

 

 

6.Mr. Avdheshkumar (Lab Attendant)

 

He joined as Lab Attendant in Project from 4/9/2008 Department of Biochemistry (AIIMS). He has 8 Years Experience in Research Lab Work. His nature of duties are like Blood sample WBC & Serum separate. Preparing Buffer for PhD and M.Sc student. He is currently handling responsibility of Bacteria Culture Lab Autoclaving and washing of equipments,Tips parking and maintaining cleaning of culture lab.

 

 

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