Default Theme
AIIMS NEW
-
अखिल भारतीय आयुर्विज्ञान संस्थान, नई दिल्ली
All India Institute Of Medical Sciences, New Delhi

Dr. Parthaprasad Chattopadhyay

Address:   Room No. 4007, Dept. of Biochemistry,

                 Convergence Block, 4th Floor,

                 All India Institute of Medical Sciences,

                 New Delhi 110029, India

Phone: 011-26549238

Email id: This email address is being protected from spambots. You need JavaScript enabled to view it.

Academic Details:

Degree

Subject

University/ Institution

Year

Ph.D.

Biochemistry

AIIMS

1996

MD

Biochemistry

AIIMS

1991

MBBS

 

Calcutta University

1986

 Positions held:

 

Position

Department

University/ Institution

Dates

Professor

Biochemistry

All India Institute of Medical Sciences,

New Delhi,

India

01/07/2011 – till date

Additional Professor

01/07/2007 – 30/6/2011

Associate Professor

01/07/2003 – 30/6/2007

Assistant Professor

24/01/1997 – 30/6/2003

CSIR Research Associate

18/02/1995 – 23/01/1997

Senior Demonstrator

18/02/1992 – 17/02/1995

Junior Demonstrator

01/01/1989 – 31/12/1991

  

Research Focus of the Lab

 1.Interaction between nanoparticles and cancer cells in vitro under hypoxic conditions and its effect on cancer stemness and invasiveness

 2.Development of HIV-1C host cell targeted anti-retroviral therapeutics using CCR5 and CXCR4 ligands on nanoparticles

After graduating in Medicine from Calcutta University, I completed my post-graduation (MD) in Biochemistry followed by PhD from All India Institute of Medical Sciences. I joined the Faculty of this Institute in 1997 while working on the promoter status of c-myc and heterozygosity status of 17p13 chromosomal region (p53 and HIC1 loci) in human glial tumors.

Initially I also collaborated on work on intra-tumor genetic heterogeneity, p53 expression and DNA repair enzymes in glioblastomas. Later on I developed interest in the study of effect of reactive oxygen species on cancer chemotherapeutic cytoxicity in context of p53 status.

My lab has also studied transcriptional gene silencing of c-myc, HPV-16 & 18 E6 & E7 proteins as well as HIV-1C by using promoter targeting short double stranded RNA. Development of targeted therapeutics using alpha-fetoprotein and Placental like Alkaline Phosphatase to target these transcription gene silencing dsRNAs to tumor cells has also been undertaken in collaboration with Prof. Subrata Sinha of National Brain Research Centre, Manesar and Prof. D.P. Sarkar of Delhi University South Campus.

We are now working on nanoparticle based targeted transcriptional gene silencing of HIV-1C by promoter directed short double stranded RNA packaged in PLGA nanoparticles with HIV host cell specific ligands on their surface.

Since hypoxia is a frequent occurrence in solid tumors including gliomas and is a cause for derangement of ROS metabolism in cancer cells, my lab investigated the effect of hypoxia on the action of various drugs on cancer cell lines. Oct4 and Sox2 are genes that we have found to be induced by hypoxia and, hence, we have also worked on the effect of hypoxia on cancer cell stemness and invasiveness with special reference to p53 and HIC1 expression.

Presently, we are investigating the uptake of nonoparticles by cancer cells under hypoxia and the effect of these particles on stemness and invasiveness of the cancer cells.

 List of Lab members (Including technicians and attendants)

 Dr Mohita Bhagat- Postdoctoral Fellow

  1. Dr Lubna Wasim- Postdoctoral Fellow
  2. Madeeha Mudassir- PhD Scholar
  3. Neha Singh- PhD Scholar
  4. Dr Gaurav Baidya- Junior Resident
  5. Dr Surbhi Gupta- Junior Resident
  6. Dr Rameshvar Tiwary- Junior Resident
  7. Dr Suman Saha- Junior Resident
  8. PA: Shri Manoj Singh
  9. Lab Technician: Mr Pappu Prasad, B.Sc (MLT)

Positions Available: None

Key publications

  1. 1.    Bhagat M, Palanichamy JK, Ramalingam P, Mudassir M, Irshad K, Chosdol K, Sarkar C, Seth P, Goswami S, Sinha S, Chattopadhyay P. (2016) HIF-2α mediates a marked increase in migration and stemness characteristics in a subset of glioma cells under hypoxia by activating an Oct-4/Sox-2-Mena (INV) axis. Int J Biochem Cell Biol. 74:60.
  2. 2.    Kassab MA, Mudassir M, Singh A, N M, Bhagat M, Palanichamy JK, Ramalingam P, Chosdol K, Sinha S, Chattopadhyay P. (2015) Gene Silencing and Activation of Human Papillomavirus 18 Is Modulated by Sense Promoter Associated RNA in Bidirectionally Transcribed Long Control Region. PLoS One. 10: e0128416
  3. 3.    Khan I, Zakaria MK, Kumar M, Mani P, Chattopadhyay P, Sarkar DP, Sinha S. (2015). A novel placental like alkaline phosphatase promoter driven transcriptional silencing combined with single chain variable fragment antibody based virosomal delivery for neoplastic cell targeting. J Transl Med. 13:254
  4. 4.    Zakaria MK, Khan I, Mani P, Chattopadhyay P, Sarkar DP, Sinha S. (2014). Combination of hepatocyte specific delivery and transformation dependent expression of shRNA inducing transcriptional gene silencing of c-Myc promoter in hepatocellular carcinoma cells. BMC Cancer 14:582
  5. 5.    Ramalingam P, Palanichamy JK, Singh A, Das P, Bhagat M, Kassab MA, Sinha S, Chattopadhyay P  (2014) Biogenesis of intronic miRNAs located in clusters by independent transcription and alternative splicing. RNA 20: 76.
  6. 6.    Singh A, Palanichamy JK, Ramalingam P, Kassab MA, Bhagat M, Andrabi R, Luthra K, Sinha S, Chattopadhyay P. (2014). Long-term suppression of HIV-1C virus production in human peripheral blood mononuclear cells by LTR heterochromatization with a short double-stranded RNA. J AntimicrobChemother. 69:404
  7. 7.    Mehndiratta M, Palanichamy JK, Pal A, Bhagat M, Singh A, Sinha S, Chattopadhyay P. (2011) CpGhypermethylation of the C-myc promoter by dsRNA results in growth suppression. Mol Pharm. 8:2302
  8. 8.    Palanichamy JK, Mehndiratta M, Bhagat M, Ramalingam P, Das B, Das P, Sinha S, Chattopadhyay P  (2010) Silencing of integrated human papillomavirus-16 oncogenes by small interfering RNA-mediated heterochromatization
  9. 9.    Pal A, Srivastava T, Sharma MK, Mehndiratta M, Das P, Sinha S, Chattopadhyay P. (2010) Aberrant methylation and associated transcriptional mobilization of Alu elements contributes to genomic instability in hypoxia. J Cell Mol Med. 14:2646.

 

My lab is presently supported by extra-mural funding from Department of Biotechnology and Department of Science & Technology, Govt. of India

 

 

Contact Us

All India Institute of Medical Sciences

Ansari Nagar, New Delhi - 110029

Board Number : +91-11-26588500 / 26588700

Fax : +91-11-26588663 / 26588641

AIIMS Exam Section Helpline numbers ( Click Here)

Important E-mail Addresses at AIIMS

Top of Page