Prof. Shashi Wadhwa
She has the distinction of being honored with awards, the most
prestigious amongst them being the Shanti Swarup Bhatnagar
Her major research interests are developmental neurobiology, quantitative morphology and electron microscopy. Her laboratory has mainly focussed on studying the developing human brain. The human spinal cord, visual pathway, cerebellar nuclei and the autonomic innervation of human urinary bladder have been studied to highlight the critical time periods during which these regions are susceptible to alterations in the microenvironment of the fetus that could result in related developmental abnormalities of varying degrees. The studies have provided baseline data for comparison with pathological material and animal experiments as well as helped in better understanding of processes involved in the development of these regions at the molecular level.
Currently, her laboratory is investigating the effects of experience driven neural activity on developing chick auditory nuclei, higher auditory association area - mediorostral neostriatum hyperstriatum ventrale and the hippocampus. Stereological methods for quantitation, immunohistochemistry and Western blot procedures are being carried out to determine the quantitative morphological and neurochemical changes consequent to enhanced prenatal auditory stimulation. These studies are aimed to help understand the basis of better neonatal performance of the chicks in response to prenatal auditory cues. Such a paradigm may also help reduce the deficits in disorders related to language acquisition and learning in children as well as improve the learning capabilities of normal children.
Wadhwa S (2002) Training of postgraduates in Anatomy. The Nat. Med. J Ind.15: 161-163.
Wadhwa S, Nag TC, Jindal A, Kushwaha R, Mahapatra AK, Sarkar C (2003) Expression of the neurotrophin receptors Trk A and Trk B in the adult human astrocytoma and glioblastoma. J. Biosci. 28: 181-188.
Wadhwa S (2003) Quantitative stereology: The use of camera lucida for counting neurons by physical disector method in chick brainstem auditory nuclei. J. Postgrad. Med. 49: 376-378.
Ray SB Wadhwa S (1999) Mu opioid receptors in developing human spinal cord. J. Anat. 195: 11-18.
Wadhwa S, Phalguni Anand, Bhowmick D (1999) Quantitative study of plasticity in the auditory nuclei of chick under conditions of prenatal sound attenuation and overstimulation with species specific and music sound stimuli. Int. J. Devl. Neurosci. 17: 239-253.
Panicker H, Wadhwa S, Roy S (2002) Effect of prenatal sound stimulation on medio-rostral neostriatum/hyperstriatum ventrale of chick forebrain: A morphometric and immunohistochemical study. J. Chem. Neuroanat. 24: 127-135.
Alladi PA, Wadhwa S, Singh N (2002) Effect of prenatal auditory enrichment on developmental expression of synaptophysin and syntaxin in chick brainstem auditory nuclei. Neuroscience 114: 577-599.
Alladi PA, Roy TS, Singh N, Wadhwa S (2005) Developmentally regulated expression of c-Fos and c-Jun in the brainstem auditory nuclei of Gallus domesticus is modified by prenatal auditory enrichment. J. Neurobiol. 62: 92-105.
Alladi PA, Roy TS, Singh N, Wadhwa S (2005) Prenatal auditory enrichment with species specific calls and sitar music modulates expression of BCl-2 and Bax to alter programmed cell death in developing chick auditory nuclei. Int. J. Devl. Neurosci. 23: 363-373.
Ray B, Roy TS, Wadhwa S, Roy KK (2005) Development of human fetal cochlear nerve: a morphometric study. Hearing Res. 202: 74-86.
Membership of national / international bodies
and scientific societies