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Professor MSc. (Chemistry), Ph.D. ( Medicinal Chemistry) , CChem FRSC (U.K).
Field of interest: Drug Addiction
A. Drug Analysis B. Neuro-Psychopharmacology (Preclinical) C. Abuse liability studies of psychotropic drugs D. Validity of drug use reporting and pattern of drug abuse among drug users E. Tobacco cessation programme
Total number of Publications till to date: 52Nos.
Paper presented in National and International Conferences and abstracts published: 43 Nos.
Details of publication from yr. 2000 onwards till to date:
1. Jain, R. Utility of Thin Layer Chromatography for Detection of Opioids and Benzodiazepines in a Clinical Setting., Addict. Behav, 25, 451-454 (2000).
2. Jain, R. Effects of Diazepam and Buprenorphine on Suppression of Withdrawal Syndrome in Rats. Ind. J. Pharmacol. 32; 63 (2000).
3. Ballakoor, K., Ray, R., Dube, S., Jain, R., Vaswani, M., Dhawan, A., An Experimental Study of Tolerance among Alcohol Dependent Individuals. Ind. J. Med Res. 113, 26-31 (2001).
4. Singh, R.K.L., Jain, R., Ray, R., Gupta, Y.K. Abuse Liability of Diazepam through Different Routes. Ind. J. Physiol. Pharmacol. 45, 181-190 (2001).
5.
Jain, R.,
Tripathi, B.M., Singh, R. Assessment of Drug Use: Comparison of
Reported Drug Use and Urinalysis. NMJI, 14, 146 (2001). 6. Jain, R., Dhawan, A., Kumar, R., Ray, R., Singh, R. Patients in Treatment Centres: Are they all Dependent. Ind. J. Psy. 43, 328-330 (2001).
7. Jain, R. Role Of Dopaminergic Drugs In Nicotine Tolerance: A Pre-Clinical Study. Ind. J. Psy. 43 (2001). 8. Jain, R., Varma. S., Mohan, D. Effect of Selective Dopaminergic Drugs in Nicotine Tolerant Rats. Drug. Alcohol. Depend. 63, S72 (2001). 9. Prasad, P.S, Ray, R. Jain, R., Chavan, B.S. Abuse Liability of Nitrazepam Among Experienced Drug Users. Ind. J. Pharmacol. 33; 357-362 (2001). 10. A. Dhawan, Jain, R., Maullick, P. Comparison of Accuracy of Self-report and Urinalysis Results in Opiate Dependent Subjects. Ind. J. Pharmacol. 34: 130-132 (2002). 11. Jain, R. A Pilot Study of the Consistency of Self- reported Drug Use and Urinalysis Results. Drug. Alcohol. Depend. 66, S84 (2002). 12. Jhingan, H.P., Jain, R., Desai N.G., Vaswani, M., Tripathi, B. M., Pandey, R.M. Validity of Self- Report of Recent Opiate Use in Treatment Setting. Ind. J. Med. Sci. 56: 495-500 (2002). 13. Jain, R., Ray, R. Blocking of Enhanced Sensitivity to Behavioral Effects of Naloxone Induced by Narcotic Agonists in Rats. Ind. J. Physiol. Pharmacol. 47: 407-414 (2003). 14. Jain , R., Mukherjee, K. Biological Basis of Nicotine Addiction. Ind. J. Pharmacol. 35: 281-289 (2003). 15. Jain, R. Self-reported Drug Use and Urinalysis Results. Ind. J. Physiol. Pharmacol. 48: 106-110 ( 2004). 16. Jain , R. Mukherjee, K., Mohan, D. Evidence for a role of nitric oxide in nicotine precipitated withdrawals in the rat. Nic. Tob. Res. 6: 873 (2004).
17. Jain , R.
Mukherjee, K. , Rajvir, S. Influence of sweet tasting solutions on
opioid
withdrawal. Brain. Res.
18.
Jain, R.,
Holtzman, S.G. Caffeine Induces Differential Cross-tolerance to the
Amphetamine-like Discrimination
19. Prasad,
HRY., Khaitan, BK., Ramam, R., Sharma, VK., Pandhi, RK., Agarwal, S.,
Dhawan, A., Jain, R.
20.
Jain, R.,
Varghese, S.T. Diagnostic usefulness of liver function tests in alcohol
and opoid dependent patients.
23.Jain, R.,
Tripathi, B.M., Varghese, S.T., Kumar, N., Kumar, M. Can you Trust
Self-reports among Injectable Drug 24. Singhal A., Tripathi BM., Pal HR, Jena R., Jain R. Subjective effects of additional doses of buprenorphine in patients on buprenorphine maintenance. Addict Behav. 32: 320-331 (2007). Chapter in Books 1. Jain, R., and Sherma, J. Planar Chromatography in Clinical Chemistry In: Encyclopedia of Analytical Chemistry Instrumentation And Applications, Meyer, R.A. (ed), John Wiley & Sons Ltd, Chichester, pp 1583-1603 (2000).
2. Ray, R. Jain, R. Mongia, M. and Kumar, R. Substance Abuse in Young People: Biological Considerations. In Mental Disorders in Children and Adolescents: Need and Strategies for Intervention, CBS Publishers, New Delhi, pp 82-87 (2005). 3. Jain, R, Role of Laboratory Services In: Lal R (Ed). Substance Abuse Disorder: Manual for Physicians, National Drug Dependence Treatment Centre, All India, Institute of Medical Sciences, New Delhi, 2005: pp127-137. 4. Jain, R. and Balhara, Y.P.S. Impact of Alcohol and Substance Abuse on Adolescent Brain: A Preclinical Perspective, Nova Science Publishers, Hauppauge, NY, USA. 2005, (in press).
Editor : and Author
2. Jain, R., and Shantanu De. Buprenorphine –
Pharmacology, Pharmacokinetics and Therapeutic Potential. In: 3. Jain, R., and Mukherjee, K. Biological Theories of Tobacco abuse. In: Proceedings of the workshop on assessment of tobacco as a gateway substance and information available on evidence relating to tobacco, alcohol and other forms of substance abuse (Eds. Dhawan A, Jain, R., Kumar, N.), New Delhi, India: Centre for Behavioral Sciences, AIIMS, sponsored by WHO India, & MOH & FW, GOI, pp. 33-38 (2004). Abstract Published from yr. 2000 onwards till to date: 1. Assessment of Drug Use: Comparision of Reported Drug Use and Urinalysis. R. Jain, B. M. Tripathi, (Abstract) in Annual National Conference of Indian Psychiatric Society, Cochin, (20-23 rd Jan. 2000). 2. Buprenorphine: Pharmacology, Pharmacokinetics and Theurapeutic Potential, R. Jain, (invited talk) in National workshop on Treatment of opiate Dependence Disorder with Special Focus on Maintenance Programme, De-addiction Centre, AIIMS, New Delhi, (17-18th April, 2000). 3. Role of Mass Spectrometry in Detection of Drugs of Abuse, R. Jain, (invited talk) in 9th ISMAS Workshop on Mass Spectrometry, Goa (12-16th Dec. 2000). 4. Role of Dopaminergic Drugs in Nicotine tolerance: A Pre-clinical Study, R. Jain, S. Varma, D. Mohan, (Abstract) in Annual Conference of Indian Psychiatric Society, Pune, (9-12th, Jan, 2001). 5. Assessment of Tolerance and Dependence: Pre-clinical Aspect, R. Jain (invited talk) in Annual Conference of Neuro-science, Lucknow (29-30th Jan. 2001). 6. Tolerance and Dependence: Preclinical Aspect, R.Jain (invited talk) in AIIMS - NIAAA Workshop on Substance Use Disorder, Drug Dependence Treatment Centre, AIIMS, New Delhi (6th March, 2001). 7. Enhanced Sensitivity to Behavioral Effects Of Naloxone. R. Jain, R.Ray in 6th NIDA / INVEST Meeting on Building International Research on Drug Abuse: Children and Youth at Risk at Scottsdale, Arizona, USA (June, 14-16th, 2001). 8. Effect of Selective Dopaminergic Drugs in Nicotine Tolerant Rats. Jain, R., Varma, S. Mohan D. R. Jain, in College on Problems of Drug Dependence, 63rd Annual Scientific Meeting, Scottsdale, Arizona, USA (June, 16-21st, 2001).
9. Evidence for an Involvement of D2 Dopamine Receptor in Mediating Nicotine Tolerance in Rats R. Jain, S. Varma, D. Mohan in Annual Meeting of Society for Research & Tobacco (SRNT) at Savannah, Georgia, USA, dated (February 20 – 23, 2002).
10. Clinical Utility of Drug Abuse Testing : Self Report
Vs. Urinalysis.
R. Jain,
in 9th
Asian Pacific Congress of Clinical 11.A Pilot Study on the Consistency of Self-Reported Drug Use and Urinalysis. R. Jain, in College on Problems of Drug Dependence, 64th Annual Scientific Meeting, Quebec City, Canada(June, 8-13, 2002). 12. Comparison of Patient self-Reports and Urinalysis in the Community outreach Clinic, R. Jain, B. S. Chavan in 7th NIDA / INVEST Meeting on Building International Research on Drug Abuse: Treatment Innovations, Quebec City, Canada (June, 13-15th, 2002). 13. Biological Theories of Tobacco Abuse , R. Jain in workshop on Assessment of Tobacco as a Gateway substance and Information on evidence relating to Tobacco, Alcohol and other Forms of Substance Abuse, All India Institute of medical Sciences, New Delhi (Sept, 4-5th, 2002). 14. Effects of Dopaminergic Drugs in Nicotine Tolerant Rats, R. Jain, S. Varma, D. Mohan, in 2nd World Assembly on Tobacco Counters Health, New Delhi, India (Sept., 29th- 3rd Oct 2002).
15. Self-Reported
Drug use Among Injectable Drug Users, R. Jain, B. M. Tripathi, S.
Singh, N. Kumar, M. Kumar in 16. Role of liver Function Tests in Assessment of Alcoholics and Opioid Addicts. R. Jain., R. Singh in 2003 NIDA International Forum, Building International Research: Emerging Trends and patterns in Drug Abuse Around the World. Miami, Florida (June, 13-19th, 2003). 17. Moderate Drinking-Preclinical Aspects. R. Jain (invited talk) In National Workshop on Responsible Drinking- Review of Evidence and Formulation of Recommendations, National Drug Dependence Treatment Centre, AIIMS, New Delhi (Sept, 1-2nd, 2003). 18. Evidence for a Role of Nitric Oxide in Nicotine Precipitated Withdrawal in the Rat. R. Jain., K. Mukherjee, D. Mohan in Fifth European Conference of the Society for Research on Nicotine and Tobacco at Padua, Italy (Nov, 18- 24th, 2003).
19. Tobacco and Nicotine Related Studies at National Drug Dependence Treatment Centre, AIIMS : An overview. R. Jain., in Fifth European Conference of the Society for Research on Nicotine and Tobacco at Padua, Italy (Nov, 18- 24th, 2003).
20. Influence of Sweet tasting solution in morphine withdrawal - A pilot study R. Jain., K. Mukherjee., in XXXVI Annual Conference of Indian Pharmacological Society, New Delhi ( Dec, 5-7th, 2003).
21. Effect of Nitric Oxide Synthase Inhibitors in Nicotine Precipitated Withdrawal Rats. R. Jain., K. Mukherjee., In World Assembly on Tobacco Counters Health, New Delhi ( March, 7-11th, 2004). 22. Role of sweet tasting solution in opiate withdrawal. R. Jain., K. Mukherjee., In Satellite Meeting of 2004 NIDA international Forum: Progress through Collaboration , San Juan, Puerto Rico (June 11-14th , 2004). 23. Effects of the NMDA receptor antagonists (Ketamine) to the operant decrement produced by naloxone in morphine - treated rat. R. Jain., In 66th Annual Scientific Meeting of College on Problem of Drug dependence, San Juan, Puerto Rico (June 12- 17th, 2004). 24. Effect of nitric oxide synthase inhibitors in nicotine dependent rats Society for Research on Nicotine and Tobacco’s: R. Jain. In 11th Annual Meeting held jointly with the 7th SRNT European Conference’ (20-23 rd March, 2005) at Prague ‘Czech Republic’. 25. Drunken Driving. R. Jain (invited talk). In. Workshop on Road Rage: A study of Aggressive behavior and intervention strategies Deptt. of Psychiatry, AIIMS, New Delhi. (May 4rth, 2005). 26. Role of laboratory in Primary Health Care. R. Jain (invited talk). In. Workshop on Managing Alcohol Abuse in Primary Care Setting: A study of Aggressive behavior and intervention strategies, National Drug Dependence Treatment Centre, AIIMS, New Delhi. (June 17th-18th, 2005). 27. Comparison of the effects of nitric oxide synthase inhibitors in nicotine dependent rats. R. Jain, K. Mukherjee, D. Mohan . In Satellite meeting of 2005 NIDA International Forum: Linking Drug Abuse and HIV/AIDS in conjuction with 67-th Annual Scientific meeting of College on Problem of Drug Dependence (CPDD) (June17th-23rd, 2005), Orlando, Florida, USA.
Number of Projects: Chief Investigator:
1.
R.
Jain.,
D. Mohan. Role of Dopamine in Experimentally Induced Nicotine
Tolerant Rats (Council of Scientific
2. R. Jain., R. Ray. Blocking of Enhanced Sensitivity to Behavioral Effects of Naloxone Induced by Narcotic Agonists in Rats (All India Institute of Medical Sciences, funded ( 1999- 2000, completed). 3. R. Jain., D. Mohan. Role of Nitric Oxide Synthase Inhibitors In Modifying Nicotine Withdrawals in Rats (Council of Scientific and Industrial Research, Govt. Of India, funded (2001- 2005, completed). 4. R. Jain. Effects of the NMDA Receptor Antagonist (Ketamine) to the Operant Decrement Produced by Naloxone in Morphine-treated Rats. (All India Institute of Medical Sciences, funded (2002- 2003, completed). Co-Investigator: 1. D. Mohan., R. Jain., H. Pal. Health Status of Workers with Chronic Opioid Exposure at Govt. Opium and Alkaloid Factory, Ghazipur, U.P., (Ministry of Finance, Govt. of India, funded 1998-2001, completed). 2. D. Mohan., R. Jain., H. Pal. Identification and Management of Alcohol Use Related Disorders in Districts Hospital in Goa. ( WHO India , Ministry of Health, Govt. of India, funded, 2002- completed). 3. A. Dhawan., R. Jain., A. Chopra. To test the effectiveness of Oral Substitution with Buprenorphine and to establish a protocol for Oral Substitution with Buprenorphine. (UNODC, 2005-ongoing). Non Funded Research Projects: Chief investigator: 1. R. Jain, A. Dhawan. Concordance between Self-reported Drug Use and Urinalysis in Opioid Dependent Subject on Maintenance in the Community (1999-2000, completed). 2. R. Jain. A comparative Evaluation of Efficacy of Diazepam and Buprenorphine In Suppression of Opioid Withdrawal Signs in the Rats (1999- 2000, completed). 3. R. Jain. Influence of Sweet Tasting Solutions in Morphine Withdrawal - A pilot study ( 2003- completed). 4. R. Jain. Effect of Nitric Oxide Synthase Inhibitor to the Operant Decrement Produced by Naloxone In morphine Treated Rats (2004-2005, completed). 5. R. Jain Role of Sweet tasting Solutions in modifying the Opioid Withdrawals in rats (2004-completed). 6. R. Jain. Effect of Nitric Oxide Synthase Inhibitor 7-NI on Sensitization to the Operant Decrement Produced by Naloxone in Morphine Treated Rats (2006-ongoing) Co-Investigator 1. A. Dhawan, R. Jain. Concordance between Self-Reported Drug Use and Urinalysis in Out patient Opioid Dependence subjects (1998-1999, completed). 2. S. Malhotra ., R. Jain. Current Pattern of Naltrexone Maintenance and Patient Compliance (2003 –2004, completed).
Thesis supervised as MD/PhD
a) Chief Guide for Postgraduate Medical Students M.D. Thesis - Seven b) Co-guide for Postgraduate Medical Students M.D. Thesis-Six c) Co-guide for Ph.D Student Thesis-One Significant Events: Awards and Honors:
a)
Was nominated
by Government of India, under United Nations Fund for Drug Abuse Control
Programme (UNDCP) and had five months advance training in ‘Analytical’
Methods of Body Fluid Analysis from September, 1990 to January, 1991 at
Institute of Legal Medicine, Forensic Toxicology Laboratory University
of Padova, Italy. During this period, was awarded United Nations
Fellowship. b) Recipient of National Institute on Drug Abuse NIDA INVEST FELLOWSHIP, US Govt. at Deptt. of Pharmacology, School of Medicine, Atlanta, Georgia 30322-3090 for a period of 13 months (1996-1997).
d) Recipient of National Institute on Drug Abuse (NIDA) international travel awards for presenting research papers in NIDA International conferences, USA (1999-2004, 2006). e) Recipient of Travel award to attend NIH Stigma and Global Health Conference at Bethesda, Maryland, USA (Sept. 2001). f) Recipient of Society for Research & Tobacco (SRNT) Global Network Travel award 2002 and 2003. g) Chaired the session "Glutamate -What's all the Excitement?” session in College on Problems of Drug Dependence, (CPDD), USA meeting on 15th June, San Juan, Puerto Rico , USA. h) Appointed as steering committee member of International Drugs of Abuse Research Society (IDARS) in Oct, 2004.
i) Recipient of WHO/NIDA/CPDD International traveling Fellowship award for participating and presenting paper in Satellite meeting of 2005 NIDA International Forum: Linking Drug Abuse and HIV/AIDS in conjuction with 67-th Annual Scientific meeting of College on Problem of Drug Dependence (CPDD) (June17th-23rd, 2005), Orlando, Florida, USA. j) Recipient of Distinguished International Scientist Collaboration Award (DISCA), National Institute on Drug Abuse, US, Govt. USA for the year 2006 from (1/6/06-31/8/06). at 5500 Nathan Shock Drive, John Hopkins Bayview Campus, Baltimore, MD, 22124, USA. Others: 1. Planned and Established the Drug Abuse Testing Laboratory at De-Addiction Centre of All India Institute of Medical Sciences, New Delhi, India. This is the first time such a laboratory has been established in the country. The laboratory started functioning in June 1989.
2.Officer- Incharge of Drug Abuse Testing laboratory at the National Drug Dependence Treatment Centre, AIIMS. Drug Tests in body fluid includes (screening and confirmation) for: opioids (morphine, heroin, codeine, dextropropoxyphene, pentazocine, buprenorphine), benzodiazepines (diazepam, oxazepam, chlordiazepoxide), Barbiturates, cannabinoids, anitihistaminics (pheniramine, promethazine) and cocaine.
3. Apart from post graduate teaching also imparting training of Drug Abuse Testing in body fluids to Laboratory personnel’s, Doctors, Nurses of various States of the country. 4. Planned and Established a ‘Pre-clinical Behavior Laboratory in the department, for carrying out pre-clinical studies. The laboratory started functioning in 1994. 5. Membership of Scientific Societies: National: Four ; International: Five 6. Chief Coordinator for organising National workshop on Treatment of Opiate Dependence Disorder with Special Focus on Maintenance Programme, De- addiction Centre, AIIMS, New Delhi, (17-18th April, 2000).
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