main
 

Departments 

Dept. of Medical Ophthalmology, Retina  & Uvea (Unit-I)
Dept. of Vitreoretinal Diseases & Trauma (Unit-II)

Dept. of Cornea & Refractive  Surgery (Unit-III)
Dept. of Cornea, Ocular Surface Disorders & Glaucoma (Unit-IV)
Dept. of  Pediatric  Ophthalmology & Oculoplasty (Unit-V)
Dept. of Squint, Neuro-ophthalmology & Glaucoma (Unit-VI)
Anesthesia and Radiology
Dept. of Community Ophthalmology
Dept. of Ocular Biochemistry
Dept. of Ocular Microbiology
Dept. of Ocular Pathology
Dept. of Ocular Pharmacy Pharmacology & Toxicology___

Department of Ocular Pharmacology Research Contributions

Malachite Green Toxicity
First reported the Ocular toxicity of Malachite green in Holi color (Hindustan times March 2006)- J Hazard Mater. 2007
 
 

Ocular drug disposition studies in progress
 

Indian Solar Ultraviolet Radiation Assessment Project- ISUVRA under WHO-INTERSUN Project
Corneal angiogenesis model for screening antiangiogenis compounds
Ocular drug disposition studies using concentric microdialysis probe
CADD experiments with Androgen receptors
CADD experiment to design ocular specific FQ
Department of Ocular Pharmacology & Pharmacy

DST-FIST Sponsored Department

In Charge: Dr.T.Velpandian - Assistant Professor
 
Faculty
              To be filled shortly
 
Dr. Alok Kumar Ravi    -  Project Investigator
Dr. S.Senthil Kumari    -  CSIR, Research Associate
 
PhD Scholars
Charu Sharma
J.Nirmal
Smrita
A.R.Vijaya Kumar
Pankaj Gupta
 
 
 

For the past 15 years, Ocular Pharmacology Department of Dr. R. P. Centre has been involved in developing newer drugs for eye, evaluating their intraocular penetration in animals and human and also to study their efficacy in animal models.     The Ocular Pharmacy in this Department is unique of its kind in India as it caters the drug requirements of Dr. R. P. Centre and render free drug service to poor and needy patients. Our Pharmacy manufacturing division has contributed well in bringing out many newer drug formulations for the first time in the world for various ophthalmic pathologies viz. Norfloxacin eye drops 0.3% for bacterial keratitis, Silver Sulphadiazine for ocular keratomycosis, Centbucridine for corneal anaesthesia, etc.

The bio-analytical facility in the department was established especially for drug evaluation in 1983 and many studies have been conducted through it  so far as evidenced from the national and international publications. In 2004, the Department developed an exclusive advanced Bio-analytical laboratory to more extensively support ocular drug research. In ‘Holi 2006’, the department made a landmark investigation about the presence of toxic dyes in the dry color powders (gulals) which gained lot of public interest. Recently, Ocular Pharmacology Department has been recognized as a DST-FIST sponsored department for the provision of High Precision Analytical Instrument for Bio-analytical work (liquid chromatography coupled tandem mass spectroscopy with triple quadrupole LC/MS/MS).

This active dispensing pharmacy extensively supports the research interests of the Ophthalmologist of Dr. R. P. Centre on all their new research initiatives. Apart from Dr. R. P. Centre it supports research in other Departments of AIIMS in preparing extemporaneous formulations. Presently this department is having 5 PhD scholars working for their thesis work in different eye research areas and having number of publications in the peer reviewed journals of international repute.   

Main Research Areas

- Ocular drug transporters modulating intraocular kinetics of drugs

- Developing algorithm for the trans-corneal penetration of drugs

- Retinal angiogenesis

- Postmenupausal dry eye

Major Facilities

-Computer Aided Drug Design Laboratory

-Experimental Ocular Pharmacology Lab

-High Precision Bio-analytical Facility (LC-MS/MS)

-High Sterile Pharmaceutical Laboratory 

 Important Publications

1:  Velpandian T, Narayanan K, Nag TC, Ravi AK, Gupta SK.  Retinal toxicity of intravitreally injected plain and liposome formulation of fluconazole in rabbit eye. Indian J Ophthalmol. 2006 Dec;54(4):237-40.  PMID: 17090874 [PubMed - indexed for MEDLINE]

 

2:  Velpandian T, Saha K, Ravi AK, Kumari SS, Biswas NR, Ghose S.   Ocular hazards of the colors used during the festival-of-colors (Holi) in India--malachite green toxicity. J Hazard Mater. 2007 Jan 10;139(2) :204-8.  Epub 2006 Jun 23.  PMID: 16904259 [PubMed - in process]

 

3:  Velpandian T, Bankoti R, Humayun S, Ravi AK, Kumari SS, Biswas NR. Comparative evaluation of possible ocular photochemical toxicity of fluoroquinolones meant for ocular use in experimental models. Indian J Exp Biol. 2006 May;44(5):387-91. PMID: 16708892 [PubMed - indexed for MEDLINE]

 

4:  Velpandian T, Ravi AK, Kumari SS, Biswas NR, Tewari HK, Ghose S. Protection from ultraviolet radiation by spectacle lenses available in India: a comparative study. Natl Med J India. 2005 Sep-Oct;18(5):242-4. PMID: 16433136 [PubMed - indexed for MEDLINE]

 

5:  Mathur R, Gupta SK, Singh N, Mathur S, Kochupillai V, Velpandian T. Evaluation of the effect of Withania somnifera root extracts on cell cycle and angiogenesis. J Ethnopharmacol. 2006 May 24;105(3):336-41. Epub 2006 Jan 10. PMID: 16412596 [PubMed - indexed for MEDLINE]

 

6:  Vedantham V, Lalitha P, Velpandian T, Ghose S, Mahalakshmi R, Ramasamy K.  Vitreous and aqueous penetration of orally administered moxifloxacin in humans. Eye. 2006 Nov;20 (11): 1273-8. Epub 2006 Sep 30. PMID: 16200061 [PubMed - indexed for MEDLINE]

 

7:  Velpandian T, Saluja V, Ravi AK, Kumari SS, Mathur R, Ranjan N, Ghose S.  Evaluation of the stability of extemporaneously prepared ophthalmic formulation of  mitomycin C. J Ocul Pharmacol Ther. 2005 Jun;21(3):217-22. PMID: 15969639 [PubMed - indexed for MEDLINE]

 

8:  Velpandian T, Mathur R, Agarwal NK, Arora B, Kumar L, Gupta SK.  Development and validation of a simple liquid chromatographic method with ultraviolet detection for the determination of imatinib in biological samples. J Chromatogr B Analyt Technol Biomed Life Sci. 2004 May 25;804(2):431-4. PMID: 15081939 [PubMed - indexed for MEDLINE]

 

9:  Jaiswal J, Gupta SK, Dash SC, Tiwari SC, Mehta SN, Gupta YK, Velpandian T. Neoral monitoring by limited sampling area under the concentration time curve in stable indian renal transplant recipients. Transplant Proc. 2003 Jun;35(4):1298-9. PMID: 12826142 [PubMed - indexed for MEDLINE]

 

10:  Talwar D, Kulkarni A, Azad R, Gupta SK, Velpandian T, Sharma Y, Rajpal, Biswas NR. Intraocular ciprofloxacin levels after oral administration in silicone oil-filled eyes. Invest Ophthalmol Vis Sci. 2003 Feb;44(2):505-9.  PMID: 12556375 [PubMed - indexed for MEDLINE]