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Departments

Department of Ocular Pharmacology Research Contributions

Malachite Green Toxicity

First reported the Ocular toxicity of Malachite green in Holi color (Hindustan times March 2006)- J Hazard Mater. 2007
 
 

Ocular drug disposition studies in progress

 

Indian Solar Ultraviolet Radiation Assessment Project- ISUVRA under WHO-INTERSUN Project

Corneal angiogenesis model for screening antiangiogenis compounds
Ocular drug disposition studies using concentric microdialysis probe
CADD experiments with Androgen receptors
CADD experiment to design ocular specific FQ
Department of Ocular Pharmacology & Pharmacy

DST-FIST Sponsored Department

In Charge: Dr.T.Velpandian - Additional Professor
 
Faculty
 Dr. Nabanita Halder, Assist. Professor
 
 
PhD Scholars
Santosh Patnaik
Madhu Nath
Hanuman Prasad,
Ankita Kotnala
Moksha Lakshmi
Ujjwal
 

 HIGHLIGHTS

 1.  DST-FIST Sponsored High Precision Bioanalytical Facility to quantify any small molecule/drug level in various biological samples by LC-MS-MS. 

2. Advanced Drug Development Facility for Ocular Neovascular Diseases (ADD-FOND) to study drugs in the experimental models of diabetic retinopathy, ARMD etc. 

3. Novel Ocular Drug Delivery Laboratory (NODDL) for the development of newer drug formulations and delivery systems (created as per GLP & GMP norms). 

4. In –Vitro cell culture facility to study the functional importance of ocular barriers in diabetic retinopathy and to screen drugs for various ocular pathological conditions.

5. GLP compliant drugs dispensing facility for RPC ward and OPDs.

6. GLP compliant corneal preservative media (M.K.Media) dispensing facility that supplies to Govt. eye banks in 19 states of India.

Areas of Interest: Drug Delivery, Drug barriers, Topical drugs, Drug Transporters, Pharmacokinetics, Quantitative structure property relationship (QSPR) , Inflammation and angiogenesis.

New Drug Discovery: Patents Filed from the Department is 6

Publications

1. Arora B, Narayanasamy A, Nirmal J, Halder N, Patnaik S, Ravi AK, Velpandian. Development and validation of a LC-MS/MS method for homocysteine thiolactone in plasma and evaluation of its stability in plasma samples. T.J Chromatogr B Analyt Technol Biomed Life Sci. 2014 Jan 1;944:49-54.  

      2.                2. Velpandian T, Kotnala A, Halder N, Ravi AK, Vikneswari A, Sihota R. Stability of Latanoprost in Generic Formulations Using Controlled Degradation and Patient Usage Simulation Studies. (Current Eye Res 2014 In press) 

3. Kumar N, Bhatnagar S, Velpandian T, Patnaik S, Menon G, Mehta M, Kashyap K, Singh V, Surajpal. Randomized Controlled Trial in Advance Stage Breast Cancer Patients for the Effectiveness on Stress Marker and Pain through Sudarshan Kriya and Pranayam. Indian J Palliat Care. 2013 Sep;19(3):180-5. 

4. Kyadari M, Fatma T, Azad R, Velpandian T. Evaluation of antiangiogenic and antiproliferative potential of the organic extract of green algae Chlorella pyrenoidosa. Indian J Pharmacol. 2013 Nov-Dec;45(6):569-74. 

5. Sinha S, Raghunandan P, Chandrashekhar R, Sharma SK, Kumar S, Dhooria S, Ekka M, Velpandian T, Ranjan S, Ahmad H, Samantaray JC, Venkatesh S, Rewari BB, Khan NH, Pandey RM. Nevirapine versus efavirenz-based antiretroviral therapy regimens in antiretroviral-naive patients with HIV and tuberculosis infections in India: a pilot study. BMC Infect Dis. 2013 Oct 17;13:482. 

6. Sharma N, Chacko J, Velpandian T, Titiyal JS, Sinha R, Satpathy G, Tandon R,Vajpayee RB. Author reply: To PMID 23246119. Ophthalmology. 2013, Sep;120(9):e63-4 

7. Nirmal J, Sirohiwal A, Singh SB, Biswas NR, Thavaraj V, Azad RV, Velpandian T. Role of organic cation transporters in the ocular disposition of its intravenously injected substrate in rabbits: implications for ocular drug therapy. Exp Eye Res. 2013 Nov;116:27-35. 

8. Nirmal J, Singh SB, Biswas NR, Thavaraj V, Azad RV, Velpandian T. Potential pharmacokinetic role of organic cation transporters in modulating the transcorneal penetration of its substrates administered topically. Eye (Lond). 2013 Oct;27(10):1196-203. 

9. Kumar S, Jain S, Velpandian T, Petrovich Gerasimenko Y, D Avelev V, Behari J,Behari M, Mathur R. Exposure to extremely low-frequency magnetic field restores spinal cord injury-induced tonic pain and its related neurotransmitter concentration in the brain. Electromagn Biol Med. 2013 Dec;32(4):471-83. 

10. Pushker N, Tejwani LK, Bajaj MS, Khurana S, Velpandian T, Chandra M. Role of oral corticosteroids in orbital cellulitis. Am J Ophthalmol. 2013 Jul;156(1):178-183.

11. Velpandian T, Gupta P, Ravi AK, Sharma HP, Biswas NR. Evaluation of pharmacological activities and assessment of intraocular penetration of an ayurvedic polyherbal eye drop (Itone™) in experimental models. BMC Complement Altern Med. 2013 Jan 2;13:1. 

12. Sharma N, Chacko J, Velpandian T, Titiyal JS, Sinha R, Satpathy G, Tandon R, Vajpayee RB. Comparative evaluation of topical versus intrastromal voriconazole as an adjunct to natamycin in recalcitrant fungal keratitis. Ophthalmology. 2013 Apr;120(4):677-81. 

13. Sonali N, Tripathi M, Sagar R, Velpandian T, Subbiah V. Clinical effectiveness of rivastigmine monotherapy and combination therapy in Alzheimer's patients. CNS Neurosci Ther. 2013 Feb;19(2):91-7.  

14. Velpandian, Thirumurthy; Nirmal, Jayabalan; Arora, Beauty; Ravi, Alok Kumar; Kotnala, Ankita. Understanding the Charge Issues in Mono and di-Quaternary Ammonium Compounds for Their Determination by LC/ESI-MS/MS. Analytical Letters, 2012,  45 (16), 2367-2376. 

15. Velpandian T, Gupta P, Ravi AK, Sharma HP, Biswas NR. Evaluation of pharmacological activities and assessment of intraocular penetration of anayurvedic polyherbal eye drop (Itone™) in experimental models. BMC Complement Altern Med. 2013 Jan 2;13:1.  

16. Sonali N, Tripathi M, Sagar R, Velpandian T, Subbiah V. Clinical effectiveness of rivastigmine monotherapy and combination therapy in Alzheimer's patients. CNS Neurosci Ther. 2013 Feb;19(2):91-7.  

17. Nirmal J, Velpandian T, Singh SB, Biswas NR, Azad R, Thavaraj V, Mittal G, Bhatnagar A, Ghose S. Evaluation of the functional importance of organic cation transporters on the ocular disposition of its intravitreally injected substrate in rabbits. Curr Eye Res. 2012 Dec;37(12):1127-35.  

18. Sharma N, Singh D, Sobti A, Agarwal P, Velpandian T, Titiyal JS, Ghose S. Course and outcome of accidental sodium hydroxide ocular injury. Am J Ophthalmol. 2012 Oct;154(4):740-749.e2. doi: 10.1016/j.ajo.2012.04.018. Epub 2012 Jul 27.

19. Panda A, Jain M, Vanathi M, Velpandian T, Khokhar S, Dada T. Topical autologous platelet-rich plasma eyedrops for acute corneal chemical injury. Cornea. 2012 Sep;31(9):989-93. 

20. Premkumar M, Gupta N, Singh T, Velpandian T. Cobalamin and folic Acid status in relation to the etiopathogenesis of pancytopenia in adults at a tertiary care centre in north India. Anaemia. 2012;2012:707402.  

19. Rajvardhan Azad, Neelima Aron, Madhu Nath, Parijat Chandra, Shoryavardhan Azad, Thirumurthy Velpandian. “Targeting various pharmacological pathways in retionopathy of prematuiry (ROP)-An experimental approach. Current Eye Research (under review).