Kidney Transplantation at AIIMS

 

The Department of Nephrology along with department of Surgery at AIIMS provides kidney transplantation of patients suffering from End Stage Kidney Disease as per the Certificate of Registration granted by appropriate authorities, since 1972. We follow the Transplantation of Human Organs Rules, 1995 and the subsequent amendments (as and when amended). The procedure for kidney transplantation at AIIMS is as under:

 

I. Registration of Patient for Transplantation

 

Patients with kidney disease have to come to the renal clinic, AIIMS, run by the department of Nephrology. Initial evaluation is done to know the cause of kidney disease, its severity, its reversibility (if any) and co-existing conditions (co-morbidities).  Subsequently patients are advised renal replacement therapy (RRT) if they have End Stage Kidney Disease (ESKD) i.e. when patient cannot be maintained on medical treatment alone (Chronic Kidney Disease Stage 5).  RRT consists of hemodialysis, Chronic Ambulatory Peritoneal Dialysis (CAPD) and/or Kidney transplantation.  It is patient and family decision, whether they want life-long dialysis (Either hemodialysis or CAPD) or kidney transplant. Medically, patient is advised kidney transplant ONLY once he/she is fit for transplant. Every patient of ESKD may not be fit for kidney transplant. Some important contraindications for transplantation include:

 

1)      Advanced Coronary artery disease or Cerebrovascular disease

2)      Active infection

3)      Pre-existing Malignancy

 

In case of any coexisting conditions, they are treated appropriately before consideration for kidney transplantation. Other investigations needed for transplantation are also carried out.  If patient e has any other associated illness, then that illness is investigated in detail and appropriately treated on its own merit, before kidney transplant may be possible. Thus, even though patient want kidney transplant and donor is available and tested, there may be waiting for transplant to solve these issues first before kidney transplant is done.

It is important to note that all registration and work-up of patient of kidney transplant is done by the department of nephrology.

 II. Donor Registration for Transplantation

 

Patients of ESKD are counseled to bring donor for registration as per existing laws of the country.  After checking blood group compatibility, complete physical examination is done.  This is followed by basic laboratory investigations to assess fitness.  Subsequently detailed tests to assess kidney function and vascular anatomy are done.  All these tests are done in step-wise manner so it takes some time. The patient is included in the waiting list after it is documented that the donor has two normal and equal functioning kidneys and the basic tests are normal.   The date of initial registration, when the donor comes with blood group report and found physically fit on initial screening is taken for the purpose of seniority.  Donor work-up takes about 4-6 weeks, as the tests are done step by step. To save time, some of the tests, if donor wishes, can be done from other clinics or hospitals. However, certain tests we want to be done in AIIMS only for the want of reliability.

 

In case a medically fit living donor is not available in the family, the patientís name is registered in the cadaver (deceased) donor kidney transplantation waiting list. Cadaver list contains basic details and contact number of patients. Waiting time and medical fitness are two most important criteria for taking seniority for cadaver transplant. Cadaver transplant is totally uncertain and waiting time for cadaver transplant cannot be predicted for any patient. Once a cadaver donor comes, patients are called as per their seniority and medical fitness. One of the other important criteria is compatibility of blood group of patient and cadaver donor.

 

III. Who can be Living Donor

 

By law, grandparents, parents, sibling, children, grandchildren and spouse can be donor and if any one of these are prospective donor, document formalities for kidney transplant are limited. If donor is other than this, whether distant relative or any friend, then there are other formalities for evaluation of donor. One of them is no objection from the state appropriate body to which donor belong. This often takes some time. Further details can be obtained from medical social workers who handled such type of kidney transplant document formalities.

 

IV. Inclusion in the Dialysis Programme at AIIMS

 

Since facilities for hemodialysis at AIIMS are limited (AIIMS has 13 dialysis stations), it is not possible to include all patients registered for kidney transplant with us in our hemodialysis programme immediately. A waiting list of all such patients registered for kidney transplantation is maintained accordingly to the date of registration of the living donor. Patients are included in our dialysis program as per their seniority. Currently we are able to include patients in our dialysis programme only 1-2 months prior to expected date of transplantation. Patients in the cadaver donor waiting list have to take dialysis outside this hospital, as their transplant waiting period in unpredictable and AIIMS cannot dialyse patients for indefinite period of time for paucity of facilities.

 

V. Cost of transplantation:

 

Cost of transplant is dependent upon many factors and for a particular patient cost can not be confirmed at the beginning. However, there are some components of cost, which are as follows:

 

Essential Basic costs:

 

           

1

Hemodialysis (3/wk) in AIIMS + Medicines Rs.15,000/- approx per month . Depending upon duration of dialysis, total cost for dialysis will vary. 

Rs.15,000/-/month

2

Cost of surgical disposable at time of transplantation

 

Rs.35,000/-

3

Post renal transplantation medicines approx. Rs.15000/- per month for rest of life 

Rs.1,5,000/-/month

4

Donor and recipient work-up approx.

This cost sometime is much more than this depending upon tests required for immunological testing of recipient for assessing fitness for transplant

 

Rs.30,000/-

 

Note: This does not include the cost of hemodialysis outside, prior to inclusion in the hemodialysis programme at AIIMS.

 Additional Cost/s (as needed):

 

Some patient may require following therapy on medical grounds, which will add to the cost mentioned above:

        Induction therapy with monoclonal antibodies at the time of transplant

        CMV prophylaxis starting after transplant

        Cost of other medication like blood pressure, high cholesterol etc.

 

Further, depending upon post transplant complications, if any, there may be cost involved for management of these complications, which cannot be predicted at the time of transplant. 

 

VI. Financial Assistance from various government agencies

 

 

    Poor patients, as per their eligibility may apply for various government sponsored illness assistance funds for which they should contact the hospital social workers.

 

VII. Blood Requirement

 

    Four to Six units of blood need to be arranged for transplant surgery, though all may not be utilized in every case, four units for patient and two units for donor.

 

 

VIII. Waiting period for Living Transplantation

 

At present AIIMS is doing three-four transplants in a week; and in view of large number of patients registered for renal transplant, current waiting period is 2-3 months approximately.

 

 

XI. Procedure for Registration in cadaver transplant waiting list:

 

∑     Patients with end-stage kidney disease on dialysis (maintenance hemodialysis or chronic peritoneal dialysis) first must register in the Renal Clinic, AIIMS.

∑     There is no medically suitable living donor

∑     Patients on maintenance hemodialysis have to continue taking hemodialysis outside AIIMS

∑     Necessary pre-transplant investigations will be done

∑      Patients will be investigated for associated illnesses.  If present, associated illnesses will be treated appropriately. Patients with untreated associated illness cannot be registered for cadaver transplant.

∑     In order to remain in the active cadaver transplant waiting list, the patients must follow-up in the Renal Clinic, AIIMS at least once every three months, or as and when required on medical ground.

 

No specific waiting period can be specified for patents in the cadaver transplantation waiting list, since it is totally unpredictable when a cadaver donor may be available.