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Ms. Asha
Bhushan |
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Designation |
Senior Technical
Officer |
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Email |
agautam@aiims.ac.in, ashaykb@yahoo.com |
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Contact Number |
+91-11-26594608,
+91-11-26593201 |
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Research Interests |
High
Intensity Protein data collection ; Structure data
Processing and refinement Cryo-cooling |
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Awards
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Selected for attending
"The
XIX IUCr Congress and General Assembly in Geneva”
2002 |
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The Outstanding
scientist of the 21st century award by
International Biographical Centre, Cambridge in
2007 |
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Bursary for the 9th
International conference on Biology and Synchrotron
radiation from 13-17 August 2007
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Invited by Prof. Kyriacos Petratos for
structure determination (BIOXIT) course in crystallography
i
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Selected for the “International conference on Neuton
scattering’ ICANS-XIX”
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Selected for
attending the CCP4 study weekend, 2010, East Midland, England.
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Recent Significant
Publications
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Kumar S, Singh N, Sinha M, Dube D, Singh SB, Bhushan A, Kaur
P, Srinivasan A, Sharma S, Singh TP.(2010): Crystal
structure determination and inhibition studies of a novel
xylanase and alpha-amylase inhibitor protein (XAIP) from Scadoxus
multiflorus.
FEBS J.:
277(13):2868-82. |
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Mir,
R., Singh, N., Vikram, G., Sinha, M., Bhushan, A., Kaur, P., Srinivasan,
A., Sharma, S. & Singh, T.P.
(2010).
Structural and binding studies
of C-terminal half (C-lobe) of lactoferrin protein with COX-2-specific
non-steroidal anti-inflammatory Drugs (NSAIDs).
Arch.
Biochem. Biophy. 500 , 196 - 202
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Mir R,
Kumar RP, Singh N, Vikram GP, Sinha M, Bhushan A,
Kaur P, Srinivasan A, Sharma S, Singh TP.
(2010). Specific interactions of C-terminal half (C-lobe)
of lactoferrin protein with edible sugars: binding and
structural studies with implications on diabetes.
Int
J Biol Macromol.47, 50-9.
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Sheikh, I.A., Singh, A.K., Singh, N., Sinha, M., Singh, S.B., Bhushan,
A., Kaur, P., Srinivasan, A., Sharma, S. & Singh, T.P. (2009).
Structural evidence of substrate specificity in mammalian peroxidases:
Structure of the thiocyanate complex with lactoperoxidase and its
interactions at 2.4A resolution.
J. Biol. Chem. 284, 14849 - 14856.
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Singh, A.K., Kumar, R.P., Pandey, N., Singh, N., Sinha, M., Bhushan,
A.,Kaur, P., Sharma, S.
& Singh, T.P. (2009). Mode of binding of the tuberculosis prodrug
isoniazid to peroxidases: Crystal structure of bovine lactoperoxidase
with isoniazid at 2.7A resolution.
J. Biol. Chem. 285 , 1569 - 1576
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Mir, R.,
Singh, N., Vikram, G., Kumar, R.P., Sinha, M., Bhushan, A., Kaur, P.,
Srinivasan, A., Sharma, S. & Singh, T.P. (2009)).
Structural basis of the prevention NSAID-induced damage of the
gastrointestinal tract by C-terminal half (C-lobe) of bovine colostrums
protein lactoferrin: Binding andstructural studies of the C-lobe
complexes with indomethacin, diclofenac, aspirin and ibuprofen.
Biophys. J. 97,
3178 – 3186
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Singh, R.K., Ethayathulla, A.S., Jabeen, T., Sharma, S., Kaur, P. &
Singh, T.P. (2005) .
Aspirin induces its anti-inflammatory effects through its specific
binding to phospholipase A2 : Crystal structure of the complex formed
between phospholipase A2 and aspirin at 1.9 Å resolution.
J. Drug
Target. 13 , 113 – 119.
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Jabeen ,T.,Sharma,S.,Singh,N.,Bhushan,A
&Singh,T.P.(2005) Structure of the Zinc –saturated
C-terminal lobe of the bovine lactoferin at 2.0 A
resolution: Acta Crystallogr
D61,1107-1115 |
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Kumar, J.,
Ethayathulla, A.S., Srivastava, D.B., Singh, N., Sharma,
S., Bhushan,A., Kaur, P., Srinivasan, A., Singh, T.P.
(2007)
Carbohydrate- binding properties of
goat secretory glycoprotein (SPG -40) and its functional
implications: Crystal structures of the Native Glycoprotein
and its four complexes with chitin –like oligosaccharides.
Acta Cryst. D63, 437-46.
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V.Mishra, A.S.Ethayathulla, R.S.Sharma, S.Yadav, Bhushan,
A., R.Krauspenhaar, C.Betzel, C.R.Babu and T.P.Singh,
Structure of a novel ribosome-inactivatig protein from a
hemi-parasitic plant inhabiting the northwestern Himalayas,
Acta Cryst.(2004).D60, 2295-2304 |
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