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Prof. T. P. Singh

Designation Distinguished Biotechnology Research Professor
Email tpsingh.aiims@gmail.com
Contact Number +91-11-26588931, +91-11-26596605
Research Interests

Structural Biology ; Biological Crystallography, Protein Structure Determination and Peptide Design ; Rational Structure Based Drug Design

Awards and Honors

































Fellowships of Academies / Societies



Fellow of the Third World Academy of Sciences :  F.T.W.A.S.
Fellow of the Indian National Science Academy : F.N.A.
Fellow of the National Academy of Sciences : F.N.A.Sc.
Fellow of the Indian Academy of Sciences : F.A.Sc.
Fellow of the Alexander von Humboldt Foundation : F.AvH.F.
Fellow of the Biotech Research Society of India:  F.B.R.S. 









Thathachari Memorial Science Award for Science and Technology 2012
Jawaharlal Nehru Birth Centenary Lecture Award of INSA 2011
Annual Award of the Instrumentation Society of India 2011
Doctor of Science, D.Sc. (h.c.) conferred by Karnataka State Open University, Mysore 2010
CSIR Foundation Day Lecture award 2010
Goyal Prize in Life Sciences  2007
Professor G.N. Ramachandran CSIR Gold Medal for Excellence in Biological Sciences and Technology 2006
Professor G.N. Ramachandran 60th Birthday Commemoration INSA Medal   2006
Sir J. C. Bose Memorial Award of the Indian Sciences -  Congress  2006
K.K. Foundation award for Science and Technology  2001
Canadian Development  agency Award    1991
Humboldt - Foundation Award   1990
Danish International Development Agency Award 1978
First Rank in M.Sc. in the University of Allahabad 1971
Member of Governing / Research Councils










Member of the Scientific Advisory Committee to the Chief Minister of Jammu & Kashmir [2010 - 2012]
Member of the Standing Committee of JNU, New Delhi [2011 - 2012]
Member of Governing Board of UGC-DAE Consortium for Scientific Research, Indore [2011 - 2013]
Member of Council of Indian Statistical Institute, Kolkata [2010 - 2012]
Member of the Research Council of Institute of Mocrobial Technology, Chandigarh  [2010 - 2012]
Member of the Board of Governors of the Indian Institute of Technology, Bhubaneshwar [2008 - 2010]
Member of the Board of Governors of the Indian Institute of Technology, Kharagpur [2005 - 2007], [2008 - 2010]
Member of the Governing Body of the National Centre for  Plant Genome Research, New Delhi [2005 - 2007]
Member of the Research Council of the Centre for  Cellular and Molecular Biology, Hyderabad [2000 - 2003], [2004 - 2006]
Member of the Research Council of the Indian Toxological Research Centre, Lucknow [2004 - 2006]
Member of the Research Council of the Central Drug Research Institute, Lucknow [2007 - 2009]
Member of the Research Council of the Institute of Genomics and Integrative Biology, Delhi [2007 - 2009]
Special Invitee to the Institute Body of the All India Institute of Medical Sciences, New Delhi [2001 - 2006]
Special Invitee to the Research Council of  Institute of Microbial Technology , Chandigarh [2007 - 2009]
Editorial Board Member





Member of the editorial board of the International Journal of Biochemistry and Molecular Biology [2011 - present]
Chief Editor of the Proceedings on Indial National Science Academy, New Delhi   [2011 - 2013]
Member of the editorial board of the Indian Journal of Biochemistry and Biophysics [2001 - 2003], [2004 - 2006]
Member of the editorial board of the International Journal : Physiology and Molecular Biology of Plants  [2000 -present]
Member of the editorial board of the Indian Journal of Physics [1997 -present]
Member of the Editorial Board of the World Journal of Biological Chemistry [2009 -present]

Recent Significant Publications


















Sharma P, Yamini S, Dube D, Singh A, Sinha M, Dey S, Mitra DK, Kaur P, Sharma S & Singh TP. (2012). Structural Studies on Molecular Interactions between Camel Peptidoglycan Recognition Protein, CPGRP-S, and Peptidoglycan Moieties N-Acetylglucosamine and N-Acetylmuramic Acid.  J Biol Chem. 287 : 22153-64. 

Sharma, P.,  Dube, D.,  Sinha, M.,  Mishra, B.,  Dey, S.,  Mal, G.,  Pathak, K.M.L.,  Kar, P., Sharma, S.  &  Singh, T.P. (2011). Multi-ligand specificity of pathogen associated molecular-binding site in  peptidoglycan recognition protein.  J. Biol. Chem. 286 : 31723-31730 

Sharma, P., Dube, D., Singh, A., Mishra, B., Singh, N., Sinha, M., Dey, S., Kaur, P., Mitra, D.K., Sharma, S. & Singh, T.P. (2011). Structural basis of recognition of pathogen-associated molecular patterns and inhibition of pro-inflammatory cytokines by camel peptidoglycan recognition protein. J. Biol Chem. 286 : 16208-16217.

Singh, A.K., Kumar, R.P., Pandey, N.,  Singh, N., Sinha, M.,  Bhushan, A.,Kaur, P.,  Sharma, S.   &  Singh, T.P. (2009). Mode of binding of the tuberculosis prodrug isoniazid to peroxidases: Crystal structure of bovine lactoperoxidase with isoniazid at 2.7A resolution.  J. Biol. Chem. 285, 1569-1576 

Mir, R., Singh, N., Vikram, G., Kumar, R.P., Sinha, M., Bhushan, A., Kaur, P., Srinivasan, A., Sharma, S. & Singh, T.P. (2009). Structural basis of the prevention  NSAID-induced damage of the gastrointestinal tract by C-terminal half (C-lobe)of bovine colostrums protein lactoferrin: Binding andstructural studies of the C-lobe complexes with indomethacin, diclofenac, aspirin and ibuprofen. Biophys. J. 97, 3178-3186

Singh, A.K., Singh, N., Sinha, M., Bhushan, A., Kaur, P.,  Srinivasan, A., Sharma, S. & Singh, T.P. (2009). Binding modes of aromatic ligands to mammalian heme peroxidases with associated functional implications : Crystal structures of lactoperoxidase complexes with acetylsalicylic acid, salicylhydroxamic acid and benzylhydroxamic acid.J. Biol. Chem. 284, 20311-20318.

Sheikh, I.A., Singh, A.K.,  Singh, N., Sinha, M., Singh, S.B., Bhushan, A., Kaur, P., Srinivasan, A., Sharma, S. & Singh, T.P. (2009). Structural evidence of substrate specificity in mammalian peroxidases: Structure of the thiocyanate complex with lactoperoxidase and its interactions at 2.4A resolution.  J. Biol. Chem. 284, 14849-14856.

Singh, A.K., Singh, N., Sharma, S., Shin, K., Takase, M., Kaur, P., Srinivasan, A. &  Singh, T.P. (2009). Inhibition of lactoperoxidase by its own catalytic product: Crystal structure of the hypothiocyanate-inhibited bovine lactoperoxidase at 2.3A resolution.  Biophys. J. 96, 646-654.