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Dr. N.C.Chandra Assistant Professor Room no. 3016, Department of Biochemistry, All India Institute of Medical Sciences, New Delhi Phone: 011-26594267 Email: nc1_chandra@hotmail.com
Brief profile: PhD : University of Calcutta Post doctoral training: Harvard Medical School , USAUniversity of Notre Dame, USALecturer: M. S. University of Baroda. : 1996 – 1998 Lecturer: D. Y. Patil Medical College, Mumbai: 1998 – 2001 Assistant Professor: Dept. of Biochemistry, AIIMS, New Delhi presently.
Running Research projects as principal investigator: · Studies on nuclear cholesterol and expression of cell cycle proteins in normal and tumor cell lines. [Sponsored by ICMR, New Delhi]. · An in vitro silencing of endogenous oxidized-LDL-receptor (LOX-1) gene by siRNA: Study of NF-kB activated expression of proinflammatory cytokines and related atherogenic proteins ------ its evaluation against anti-inflammatory cytokine mediated responses. [Sponsored by DBT, New Delhi]. · Intracellular cholesterol homeostasis and cell proliferation. [Sponsored by Dept. of atomic energy, BARC, Mumbai].
· Study on feedback regulation of intracellular cholesterol and T cell population in mice by immunogen, mitogen and carcinogen [Sponsored by AIIMS, New Delhi].
Member1. Association of Clinical Biochemists, India. 2. Indian Immunology Society. 3. Indian Society for Atherosclerosis Research 4. Indian Society of Cell Biology 5. Society of Biological Chemistry, India.
STUDENTS: PhD: Ms Albina Arjuman (July 2008 – June 2013) Thesis title: Modulation of the oxidized-LDL-receptor and its effect on pro-and anti- inflammatory cytokines. e.mail: albina_arjuman@rediffmail.com MD: Dr. Puja Beriwal (Januaray 2009 – December 2011) Thesis title: Association of plasma risk factors in obese subjects with leptin, insulin and their receptors – a pilot study. e.mail: drpujaberiwal@rediffmail.com Dr.Govind Singh (July 2009 – July 2012) Thesis title: Cholesterol homeostasis and expression of cell cycle proteins (cyclin E and cdk2) in normal prostate, benign prostatic hyperplasia and carcinoma prostate cases: a pilot study e.mail: govindaiims@rediffmail.com
Dr. Shrimanjunath (July 2009 – July 2012)
Thesis title: Insights of cholesterol homeostasis in lymphocyte of normal and chronic lymphocytic leukemia subjects: a case control pilot study e.mail: doc_manjunath@yahoo.co.in Dr Amarpreet Kaur (July 2010 – July 2013) Thesis title: Study of feedback regulation of intracellular cholesterol and immunogenic response by T cells using immunogen, mitogen and chemical carcinogen in mice model. e.mail: apreet1412@gmail.com Dr. Nimisha Saxena (July 2010 – July 2013) Thesis title: Study of feedback regulation of intracellular cholesterol and immunogenic response by B cells using immunogen ,mitogen and chemical carcinogen in mice model. e.mail: drnimisha0504@yahoo.com
RESEARCH & IMPORTANT PUBLICATIONS a. Research interests – 1. Studies on cholesterol homeostasis by LDL receptor regulation and the effects of insulin, thyroxin, Leptin and their receptors whose deficiencies are associated in developing atherosclerosis. 2. Intracellular cholesterol homeostasis and cell proliferation. 3. Cholesterol homeostasis and immune system.
b. Important Publications – 1. Nimai C. Chandra, Mary B. Doody and Roger K. Bretthauer. Specific lipids enhance the activity of UDP-GlcNAc:Dolichol Phosphate GlcNAc-1-Phosphate Transferase in intact rat liver endoplasmic reticulum membrane vesicles. Arachives Biochem. & Biophy. 290(2), 345 - 354, 1991.
2. N.C.Chandra, D.W.Welsh, M.B.Doody and R.K.Bretthauer. Alteration of microsomal UDP-GlcNAc:Dolichol Phosphate, GlcNAc-1-Phosphate Transferase (GPT) activity by nonspecific phospholipid transfer protein. FASEB J. 6(1) , 231, 1992.
3. Nimai C. Chandra, Mary J. Spiro and Robert G. Spiro. Identification of a glycoprotein from rat liver mitochondrial inner membrane and demonstration of its origin in the endoplasmic reticulum. J. Biol. Chem. 273(31), 19715 - 19721, 1998.
4. Gopalakrishnan R. and N.C.Chandra. Estradiol regulates Insulin dependent stimulation of LDL-receptor expression in HepG2 cells. Indian J. Clin. Biochem. 21(1), 8 – 14, 2006.
5. Gomathy Sethuraman, Selvendran Sugandhan, Gautam Sharma, Nimai Chand Chandra, Kudligi Chandramohan, Aggarwal Komal, Vinod K Sharma. Familial homozygous hypercholesterolemia: report of two cases and review of literature. Pediatr Dermatol 24(3), 230 – 234, 2007 .6. Gopalakrishnan R, A. Rana and N. C. Chandra. Study of low-density lipoprotein receptor regulation by oral (steroid) contraceptives: desogestrel, levonorgestrel and ethinyl estradiol in JEC-3 cell line and placentral tissue. Contraception 76: 297 – 305, 2007.
7. G. Ramakrishnan, N.C.Chandra, Regulation of low density lipoprotein receptor activity by insulin and steroids in model cell culture system. Abstract No. 144. J. Clin. Lipidology 2(5S) 2008
8. Albina Arjuman, Hemlata Pandey and Nimai Chand Chandra. Effect of a combination oral contraceptive (desogestrel + ethinyl estradiol) on the expression of low-density lipoprotein receptor and its transcription factor (SREBP2) in placental trophoblast cells. Contraception 84(2): 160 – 168, 2011
9. Shilpa Suneja, Gopalakrishnan Ramakrishnan, Nikhil Tandon and N.C.Chandra. Modulation by insulin of the co-localized LDL receptor in normal and Type-I Diabetic subjects. International Journal of Clinical Medicine. 2(3): 231 – 245, 2011
10. Hemlata Pandey, Albina Arjuman, Kallol K. Roy, Nimai Chand Chandra. Reciprocal co-ordination of a combination oral contraceptive containing (desogestrel+ethinyl estradiol) on the expression of LOX-1 and LDLR in placental trophoblast cells. Contraception: In Press.
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