Dr. D.N. Rao

Professor

Room no. 3015, Department of Biochemistry,

All India Institute of Medical Sciences,

New Delhi

Phone no. : 011- 011-2653545(O), 011-26195609 (R) 9868592706 (M)

Email: dnrao311@rediffmail.com

 

Dr. D.N. Rao, obtained his M.Sc. (1972) and Ph.D (1978) degrees.   Presently, he is a Professor in the Department of Biochemistry, AIIMS.  Currently, he is the elected General Secretary of Indian Immunology Society 2008.

He is a member of various scientific organization like Indian Immunology Society, Society of Biological Chemists of India, Association of Clinical Biochemists of India, The Indian Society of Parasitology, Molecular Immunology forum and New York Academy of Sciences, Society of Free Radical Research India. He is a  Treasurer of Indian Immunology Society (IIS) for five years.  He has organized 9th APCCB International Conference at Ashok Hotel, New Delhi 2002.   He has organized 33rd Indian Immunology Society Conference at AIIMS during 28-31 January, 2007 and he also organized SFRR Satellite Meeting 11 & 12 Feb., 2008 at AIIMS.

Dr. D.N. Rao is currently involved in teaching Biochemistry and Immunology to various professional courses.  His research interest includes Biochemistry and Immunology of infectious diseases.  His citation spans developing peptide based immunogens for vaccine design and immuno-diagnostics for diseases like Malaria, HIV, and Plague. His interest also lies in immunology of leprosy. He has guided a large number of students for Ph.D, M.D. and M.Sc degrees.  He has generated extramural research grants from DST, DBT, ICMR, DAE, CSIR and Ministry of Health and Family Welfare.  He reviewed large number of manuscripts of Immunology and Biochemistry published in various international/national journals.  He is Officer-in-Charge of both Small Animal and Primate Research Facility. 

He is an Editor in Chief of “Indian Journal of Clinical Biochemistry” (IJCB) for about five years.  He has received a large number of Awards/oration for his contribution in Biochemistry and Immunology.  He is recipient of Prof. B.K. Aikat Oration Award of ICMR for Contribution in Tropical Diseases, 1993; Prof. V.M. Thakor Award for contribution in the field of Biochemistry by Institute of Medical Technology, Udhna (Surat) under the aegis of Span Research Center, 1998; Dr. K.C. Kandhari memorial Oration for contribution in leprosy by AIIMS 1998; Seth GS Medical College & KEM Hospital Oration by ACBI, 1998; Chaturvedin Ghanshyam Das Jaigopal Award for Immunology 1997 by ICMR; Hari Om Ashram Alembic Research Award-2000 Basic Research in Medical Science by MCI; Professor C.R. Krishna Murthi Lecture Award by SBC during 2002; Dr. & Mrs. G.P. Talwar Oration Award 2003 by ACBI; ICMR award for contribution in Biomedical Research 2006 for developing subunit vaccine in Nano Particles, Man of year by American Biographical Institute of USA-2002, Outstanding Scientist Worldwide-2007 by IBC.

He has published more than 100  research articles in International and National Journals.  He has guided 20 Ph.D., M.D. 3, M.Sc. and M. Biotech 20.  Currently there are 3 Ph.D. students and two post doctoral students working with me in various problems of country priority in medical sciences. Dr. D.N. Rao is an elected Council Member from India in FIMSA. 

STUDENTS

i. MSc:

Mr. Rupesh Srivastava - Cell-mediated immune response with epitopic MAP construct of V antigen of Yersinia pestis

ii. PhD:

a. Mr. Riyasat Ali - Multiple antigen peptide approach for immunoprophylaxis of plague

b.Mr. Dablu Lal Gupta - Role of Immuno-Clinical and cytokine gene polymorphism correlation with recovery in patients with posttraumatic shock

c. Mr. Pradeep Kumar Nagar - Identification and immunological characterization of epitopes of envelope and capsid  proteins of Chikungunya virus

Post-doctoral trainees

a.       Dr. Raza Ali Naqvi

b.      Dr. Santwana Bhatnagar

 

RESEARCH & IMPORTANT PUBLICATIONS

a. Research interests –

1.      Developing peptide based diagnosis for malaria, HIV, Yersinia pestis and chikungunia.

2.      Chemical synthesis of peptides and study their  immunomodulatory, immunochemical and immunoregulatory mechanism associate with  leprosy, malaria, HIV, Y.pestis and Chikungunia.

 

b. Important Publications –

 

1.      Th3 immune responses in the progression of leprosy via molecular cross-talks of TGF-β CTLA-4 and Cbl-b, Sudhir Kumar, Raza Naqvi, Neena Khanna & Rao D.N., 2011,  Clinical Immunology (In press).

 

2.      Disruption of HLA-DR raft, deregulation of Lck-ZAP-70-Cbl-b switches and miR181a towards T cell hyporesponsiveness in leprosy, Sudhir Kumar, Raza Naqvi, Neena Khanna & Rao D.N. 2011, Mol. Immun, 48, 1178-1190.

 

3.      Crucial epitopes of Wuchereria bancrofti abundant larval transcript recognized in natural infection.

Madhumathi J, Pradiba D, Prince PR, Jeyaprita PJ, Rao D.N., Kaliraj P., Eur. J. Clin Microbiol Infect Dis. 2011, 29, 1481-1486.

 

4.      Evaluation of synthetic peptides of WbSXP-1 for the diagnosis of human lymphatic filariasis, Panduragan Pandiaraja, Chakkaravarthy Arunkumar, Subhash Lasmanappa Hoti, Rao D.N., P. Kaliraj, Dign. Microbiol. Infect. Dis. 2010, 68, 410-415.

 

5.      Identification and characterization of nematode specific protective epitopes of B. malayi TRX towards development of synthetic vaccine construct for lymphatic filariasis, Jayaprakasam Madhumathi, Prabhu Rajaiah Prince, Gandhirajan Anugraha, Pote Kiran, Rao D.N., Maryada Venkata Rami Reddy & Permumal Kaliraj, Vaccine, 2010, 28, 5038-5048.

 

6.      Induction of mucosal and systemic humoral immune responses in murine system by intranasal immunization with peptide antigens of P. vivax and CpG oligodeoxynucleotide (ODN) in microparticle delivery,  Ajaz Ahmad Bhat, Ratenesh K. Seth, Sudhir Kumar, Sukla Biswas & Rao D.N., Int. Immuno. Pharmac. 2009, 9, 1197-1208.

 

7.      Acquired immune response to defined Plasmodium vivax antigen in individuals residing in northern India, Ratnesh K. Seth, Ajaz A. Bhat, D.N. Rao & Sukla Biswas, Microbes and Infection,  2010, 12(3), 199-206.

 

8.      Induction of cell mediated immune responses to peptide antigens of P. vivax in microparticles using intranasal immunization,  Ajaz Ahmad Bhat, Ratenesh K. Seth, Sudhir Kumar,  Sukla Biswas & Rao D.N., Immunological Investigation 2010, 39 (4-5) 483-499.

 

9.      Protective effect of resveratrol and vitamin E aginst thanol-induced oxidative damage in mice: Biochemical and immunological basis, Subir Kumar Das, Sukhes Mukherjee, Geetanjali Gupta, Rao D.N. and D.M. Vasudevan,  IJBB, 2010, 47, 32-37.

 

10.  Cell mediated immune response and Th1/Th2 cytokine profile of B-T constructs of F1 and V antigen of Yersinia pestis, Geetanjali Gupta, Arif Azam Khan & Rao D.N., Scand. J.  Immunol. 2010, 71, 186-198.

 

11.  Humoral immune responses and protective efficacy of sequential  B &T cell epitopes of V antigen of Y. pestis by intranasal immunization in microparticles, Jayaprakash Babu U.S.,  Ajaz Ahmad Bhat & Rao D.N., Med Microbiol Immunol  2009 198 (4), 247-256.

 

12.  Intranasal administration of peptide antigens of HIV with mucosal adjuvant CpG ODN coentrapped in microparticles enhances the mucosal and systemic immune responses, Par Bahadur Pun, Ajaz Ahmad Bhat,  & Rao D.N.,  International Immunopharmacology 2009, 9,468-477.

 

13.  Time dependent effects of ethanol on blood oxidative stress parameters and cytokines, Das S.K., Vardhan S.G. Gupta, Rao D.N. and D.M. Vasudevan. Ind. J. Biochem. Biolphy. Feb. 2009, 46(1), 116-21.

 

14.  Protective effect of resveratrol and vitamin E against ethanol-induced oxidative damage in mice: Biochemical and immunological basis, Subir Kumar Das, Sukhes Mukherjee, Geetanjali Gupta, Rao D.N. and D.M. Vasudevan . Ind. J. Biochem. Biophy. November. 2009, 46, 1-6.

 

15.  Suppressive effect of Strychnos nux-vomica on induction of ovalumin-specific IgE antibody response in mice, Govinda Rao Duddukuri, A. Naga Brahmam & Rao D.N., IJBB, 45, 341-344, 2008 .

 

16.  Identifying B and T epitopes and studying humoral, mucosal and cellular immune response of V antigen of Y. pestis,  Arif A. Khan, Jaya P. Babu & Rao D.N., Vaccine 2008 26(3), 316-332.

 

17.  Inhibition of apoptosis activation of  NKT cells and upregulation of CD40 and CD40L mediated by M. leprae antigen(s) combined with murabutide and Trat peptide in leprosy patients,  Vineeta Chattree, Neena Khanna, Vandana Bisht , and D.N.Rao., Mol Cell Biochem. 2008 Feb;309(1-2):87-97.

 

18.  Liposomal delivery of Mycobacterium leprae antigen(s) with murabutide and Trat peptide inhibits Fas-mediated apoptosis of peripheral blood mononuclear cells derived from leprosy patients, Vineeta Chattree, Neena Khanna, Vandana Bisht & Rao D.N., Ind. J. Biochem. Biophy., 2007, 44, 386-393.

 

19.  Alterations in T cell signal transduction by M. leprae antigens is associated with downregulation of second messengers PKC, calcium, calcineurin, MAPK and various transcription factors in leprosy patients, Vineeta Chattree, Neena Khanna and D.N.Rao.   Mol.  Immunol., 2007, 44, 2066-2077.

 

20.  Alleviation of collagen-induced arthritis by plumbago zeylanica in Mice, Aparanji Poosarla, B. Veerendra Kumar, T. Raghava Rao, Rao D.N. and Rama Rao Athota., Pharmaceutical Biology, 2007, 45 (1), 54-59.

 

21.  Effect of lecithin with vitamin-B complex and tocopheryl acetate on long term effect of ethanol induced immunomodulatory activites, Subir Kumar Das, Geetanjali Gupta, Rao D.N. and D.M. Vasudevan, Indian J. Exp. Biol., 2007, 45, 1-6.

 

22.  Obstructive infertility: Changes in the histology of different regions of the epididymis and morphology and spermatozoa, P.C. Pal, Monika Manocha, M.M. Kapur, D.N. Rao and M. Rajalakshmi. 2006 Andrologia, 37, 1-9. 

 

23.  Development of diagnostic reagents: Raising antibodies against synthetic peptides of PfHRP-2 and LDH using microsphere delivery, Deepak Tomar, Sukla Biswas, Vinita Tripathi and Rao D.N., Immunobiol. 2006, 211 (10), 797-805.

 

24.  Inducing systemic and mucosal immune responses to B-T construct of F1 antigen of Yersinia pestis in microsphere delivery, Vinita Tripathi, K.T. Chitralekha, Anand R. Bakshi, Deepak Tomar, R.A. Deshmukh, M.A. Baig and Rao D.N.,  Vaccine 2006, 24 (16), 3279-3289.

 

25.  Semen quality and sperm functional parameters in fertile Indian men, P.C. Pal, M. Rajalakshmi, M. Manocha, R.S. Sharma, S. Mittal and Rao D.N. (2006) Andrologia 38, 21-25. 

26.  Enhanced mucosal and systemic immune response with intranasal immunization of mice with HIV peptides entrapped in PLGA microparticles in combination with Ulex Europaeus-I lectin as M cell target, M. Manocha, P.C Pal, M. Chitralekha, Beena Elizabeth Thomas, Vinita Tripathi, Sidhartha Dutta Gupta, Ramesh Paranjape, Smita Kulkarni, and Rao D.N. (2005), Vaccine, 23, 5599-5617.

 

27.  Investigation of the kinetics of histidine-rich protein 2 and of the antibody responses to this antigen, in a group of malaria patients from India, S. Biswas, D. Tomar and Rao D.N. (2005), Annals. Tropical Medicine & Parasitology, 99, 1-10.