All India Institute of Medical Sciences

Dr Alpana Sharma

Additional Professor

Phone no. (O) : 011- 26546665

Email: dralpanasharma@gmail.com

Dr Alpana Sharma joined the Department in 2003. She obtained her M.Phil and Ph.D Degrees from J N Medical College, Aligarh Muslim University. She has worked as post doctoral fellow and Scientist at Centre for Biotechnology, Anna University, Chennai, Banaras Hindu University, Varanasi and Maulana Azad Medical College, New Delhi.

Her broad area of research interests in human health and diseases include cancer research and autoimmune skin disorders pemphigus and air borne contact allergy parthenium. She is involved in studying Signaling mechanisms of angiogenesis and microenvironment in cancers (Multiple myeloma, bladder carcinoma and cervical cancer), Molecular and proteomic analysis of diagnostic biomarkers and Immunological & molecular potential of T lymphocytes and their cytokines in cancers. Her other area of research includes immunopathogenesis of skin disorders pemphigus and parthenium dermatitis.

Awards and Honours

1. Lady Tata Memorial Trust Fellowship in 1983-85,

2. Indo-French Fellowship in 1985-86,

3. AACR-NCI International Investigator Grant by American Association for Cancer Research at Houston, in 2009.

4. Travel Grant from International Gynecological Cancer Society at Prague in 2010.

5. Membership of National Academy of Medical Sciences, India,

6. Active membership of American Association for Cancer Research, USA

7. Membership of International Gynecological Cancer Society, USA

8. Life member Indian Immunology Society, Indian Association for Cancer Research, Association of Clinical Biochemists and Free Radical Research, India.

STUDENTS

i. MSc:

Seema Chugh: Expression of Cytokines and Transcription factor of Th17 cells in patients of Transitional Cell Carcinoma of Urinary Bladder

Rajni Kumari: Effect of Differentiation Inducing Factor-1 on proliferation and VEGF expression in multiple myeloma cells

ii. MD:

Dr Asothai R Title: Study of cytokines, transcription factors, chemokine receptors and their ligands of Th17 and Treg cells in Pemphigus vulgaris

RESEARCH & IMPORTANT PUBLICATIONS

a. Research interests –

1. Immunopathogenesis of skin disorders: Pemphigus and Parthenium dermatitis

2. Signaling mechanisms of angiogenesis and microenvironment in cancers (Multiple myeloma, bladder carcinoma and cervical cancer)

3. Molecular and proteomic analysis of diagnostic biomarkers in Bladder cancer and Multiple myeloma

4. Immunological and molecular potential of T lymphocytes and their cytokines in cancers

b. Important Publications –

1. Satyam A, Singh P, Badjatia N, Seth A, Sharma A. A disproportion of Th1/Th2 cytokines with predominance of Th2, in urothelial carcinoma of bladder. Urologic Oncology. 2011, 29(1):58-65.

2. Satyam A, Singh P, Sharma M, Seth A, Sharma A. CYFRA 21-1: A potential molecular marker for non-invasive differential diagnosis of urothelial carcinoma of bladder. Biomarkers 2011;16(5):413-421

3. Joshi S, Khan R, Sharma M., Kumar L, Sharma A. Angiopoietin-2: A potential novel diagnostic marker in Multiple Myeloma. Clin Biochem. 2011, Feb 12. [Epub ahead of print]

4. Khatri R, Mukhopadhyay K, Verma K.K, Sethuraman G, Sharma, A. Genetic predisposition due to lower producers of IL-10 (-) 1082 G>A & (-) 819 C>T loci but no endowment due to IFN-g (+) 874 A>T locus to Parthenium dermatitis in Indian cohort. British J Dermatology, 2011 Feb 17. [Epub ahead of print]

5. Khandpur S, Sharma VK, Pathria G, Satyam A. Sharma A. Comparison of enzyme-linked immunosorbent assay test with immunoblot assay in the diagnosis of pemphigus in Indian patients. Indian J Dermatol Venereol Leprol. 2010; 76(1):27-32.

6. Akhtar N, Verma K.K, Sharma A. Study of Pro and Anti-inflammatory Cytokine Profile in the Patients with Parthenium Dermatitis. Contact Dermatitis. 2010, 63(4):203-8.

7. Badjatia N, Satyam A, Singh P, Seth A, Sharma A. Altered antioxidant status and lipid peroxidation in Indian patients with urothelial bladder carcinoma. Urologic Oncology.2010, 28(4):360-7.

8. Sharma A, Khan R. Joshi S, Sharma M, Kumar L. Dysregulation in Th1/Th2 cytokine ratios in multiple myeloma patients. Leukemia Lymphoma. 2010, 51(5) :920-7.

9. Satyam A, Khandpur S, Sharma VK, Sharma A. Involvement of T(H)1/T(H)2 cytokines in the pathogenesis of autoimmune skin disease-Pemphigus vulgaris. Immunol. Invest. 2009; 38(6):498-509.

10. Sharma A, Satyam A, Rajappa M, Sharma M. Oxidant/anti-oxidant dynamics in patients with advanced cervical cancer: correlation with treatment response. Mol Cell Biochem. 2010, 341(1-2):65-72.

11. Akhtar N, Satyam A, Anand V, Verma KK, Sharma A. Dysregulation of T(h) type cytokines in the patients of Parthenium induced contact dermatitis. Clin Chim Acta. 2010, 411(23-24):2024-8.

12. Joshi S, Tiwari A , Mondal B, Sharma A, Oncoproteomics- A review. Clinica Chimica Acta. 2010 , 412:217-226.

13. Sharma A, Satyam A, Sharma M. Cytokines (TH1 and TH2) in patients with advanced cervical cancer undergoing neoadjuvant chemoradiation: correlation with treatment response. Int J Gynecol Cancer. 2009; 19(7):1269-75.

14. Sharma A, Tripathi M, Satyam A, Kumar L. Study of antioxidant levels in patients with multiple myeloma. Leuk Lymphoma. 2009; 50(5):809-15.

15. Khan R, Satyam A, Gupta S, Sharma VK, and Sharma A. Circulatory levels of antioxidants and lipid peroxidation in Indian patients with generalized and localized vitiligo. Arch Dermatol Res. 2009; 301(10):731-7.

16. Gowsami B, Rajappa M, Sharma, M & Sharma, A Inflammation: Its role and interplay in the development of cancer, with special focus on gynecological malignancies. Inter. J Gynecol Cancer; 2008; 18(4):591-599.

17. Sharma A, Rajappa M, Saxena A & Sharma M Cytokine profile in Indian females with cervical intraepithelial neoplasia and cancer cervix. International J. Gynecological Cancer. 2007; 17(4): 879-885.

18. Sharma A, Satyam A and Sharma JB Leptin, IL-10 and Inflammatory Markers (TNF-a, IL-6 and IL-8)in Pre-Eclamptic, Normotensive Pregnant and Healthy Non-Pregnant Women Am J of Reprod Immunol, 2007; Jul;58(1):21-30

19. Sharma A, Saxena, Aand Sharma. M Telomerase Activity As Tumour Marker In Detection Of Cancer In Indian Women With Cervical Intraepithelial Neoplasia And Cervical Cancer. Mol. Diagnosis and Therapy, 2007; 11(3):193-201