
Introduction
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Nuclear Medicine is a branch
of medical science where radionuclides are used for diagnosis and
treatment of human diseases. Discovery of artificial radioactivity and
development of nuclear reactors and particle accelerators have played a
significant role in radiotracer technology. Organ/tissue specific
compounds, known as radiopharmaceuticals, are administered to the patient
for diagnostic and therapeutic procedures. Nuclear medicine imaging and
non-imaging procedures provide important information about functional
status of the body organs. Radiotracer technology made it possible to
define disease in terms of physiology and biochemistry rather than anatomy
or histopathology. Ultrasonography, computed tomography (CT) and magnetic
resonance imaging (MRI) continue to define disease on the basis of
abnormal structure. Single photon emission tomography (SPECT)
permits 3D reconstruction of data, increasing the sensitivity and
anatomical localization of lesions in the skeleton, brain and heart. The
sensitivity of localization of tumors is also increased. We are lucky to
have such a system soon in our facility at our institute.In nuclear
medicine the emphasis is on function and chemistry rather than structure.
Radioactive tracers of glucose, fatty acids, amino acids make it possible
to examine the growth and development of the organs of the body, the
regeneration and repair when injured, and the response to drugs. Advances
in molecular biology have made a dramatic impact on the practice of
medicine. This has led to the birth of “Molecular Nuclear Medicine”.
Studies with receptor based radiopharmaceuticals provide insight into the
biochemical processes of proteins as they carry out instructions from
genetic coding. These studies are possible with the help of positron
emission tomography (PET) . A PET system (PET/CT) with 11 MeV
Cyclotron has
Radionuclides are also used for therapy of malignant and non-malignant conditions. A lot of progress has taken place over the past few years in therapeutic nuclear medicine. With the use of suitable radiopharmaceuticals targeted therapy is also possible.
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