Dr. Jaya Sivaswami Tyagi , M.Sc.,Ph.D
Professor ,Biotechnology

Education / Professional Studies:  I.S.C., Loreto Convent, Lucknow, 1969; B.Sc. from University of Delhi, 1973; M.Sc. from University of Delhi, 1975; Ph.D. from University of Delhi, 1979; Post doctoral training at Laboratory of Molecular Biology, National Cancer Institute, NIH, USA (1979-1983).  

Current research interests:

·         Molecular pathogenesis with reference to dormancy adaptation of Mycobacterium tuberculosis.

·         TB Inhibitor discovery and development

·         Deciphering host-M. tb  interactions

·         Developing a tool box for the diagnosis of tuberculosis.

Postgraduate teaching and training: 24 years teaching of Bacterial Genetics, Molecular Biology and Recombinant DNA technology Theory and Practical courses. Supervisor for Ph.D., M. Biotech, M.D. and D.M. candidates.

Membership of Professional Bodies: Society of Biological Chemists (India), Microbiological Society of India, Indian Society for Cell Biology, American Society of Microbiology.

Fellowships and membership of professional bodies:

            ·         Member, Guha Research Conference

            ·         Fellow, National Academy of Sciences, India

·         Fellow, Indian Academy of Sciences

·         Fellow, Indian National Science Academy 

Awards:

·      National Science Talent Scholarship   

·      University Gold Medal

·      Dr. Kona Sampath Kumar Memorial Prize

·      P.S. Sarma Memorial Award (SBCI)

·      National Women Bioscientist Award

·      New Millennium Science Medal (Indian Science Congress)

·      Tata Innovation Fellowship (DBT, Govt. of India)

Research experience:

·         36 years experience in Molecular Biology, Biochemistry and Molecular Microbiology

·         28 years experience in Mycobacteriology

Significant research contribution:

·         Discovery and elucidating mechanism of action of DevR-DevS two component system of Mycobacterium tuberculosis using RNA subtractive hybridization

·         Development of TB diagnostic tool box

·         Development of novel dormancy cell infection model for Mycobacterium tuberculosis

·         Development of inhibitors against DevR dormancy regulator

Technologies developed:                                

·         Multipurpose Biosafe TB diagnostic technology (USP technology), transferred to Industry

·         High throughput screening assays to identify inhibitors of M. tuberculosis DevR-DevS system.

·         Cell-based screening assays for compounds active against dormant and replicating mycobacteria.

·         Development of a vitamin C-based dormancy infection model for M. tuberculosis.

Publications: 82

Patents: Indian 5; International 3