Dr. Nibhriti Das

Professor

Department of Biochemistry,

All India Institute of Medical Sciences, New Delhi-110029

Tel. Office: 011-26593467 Res.: 011-26588842

E-mail: nibhriti@hotmail.com

 

Ph.D. in Biochemistry from Lucknow University in the year 1976. Post Doctoral experience at ITRC Lucknow and AIIMS. AIIMS faculty since 1984 in the Department of Biochemistry, Professor in the Department since 2003. Adjunct Faculty of the K.L. Wig CMET, AIIMS.

 Got diploma certificate in Medical Education Technology from Technology Transfer Centre, University of Dundee, Scotland, UK. Involved in the curriculum reform for UG and PG for the department of biochemistry. Served as a faculty at the Arabian Gulf University for 2 years w.e.f. end Dec 1991, got trained in problem-based learning. Initiated PBL for teaching- learning of biochemistry by the medical undergraduates.  UG teaching co-coordinator since 1985. Research experience and projects include: Biochemical toxicology and immunotoxicology of pesticides; Influence of pesticides in cardiovascular disorder nutrition and communicable disease like TB; Complement and complement regulatory proteins in the pathophysiology of glomerulonephritis ,RA and SLE; Genetic & biochemical risk markers for hypertension and coronary artery disease, severe complications of falciparum malaria; cytokine-complement interactions in autoimmune disorders and role of complement proteins as biomarkers for GN, RA & SLE.

Co-editor of a book “Essentials of Practical Biochemistry” CBS Publishers & Distributors

Written several chapters in Textbooks for UG Students. 76 original research papers.

 

 

Membership of scientific bodies:

Life Member of the

  1. Indian Immunology Society, IUIS, FIMSA

  2. National Environmental Science Academy

  3. Association of Cell Biology

  4. Association of Clinical Biochemists of India

  5. Indian Society for Atherosclerosis Research

  6. International Society for Atherosclerosis Research

 

Member of the Executive Committee:

      1.      Treasurer of the Indian Immunology Society for the year 2010-2012

      2.      National Environmental Science Academy, Member of the Executive Committee

      3.      Indian Society for Atherosclerosis Research

Others:

  1. International Complement Society

         5.      Professional Member of the American Heart Association

         6.      Member of the advisory board of the Biosciences Research Institute, Chennai, India

 

 

STUDENTS

i. MSc:

ii. MD:

iii. PhD:

1. Devyani Anand: Expression and modulation of leukocyte Complement Receptor 1 and CD59 (Protectin) in relation to rheumatoid arthritis

 

2. Roma Pahwa: Expression and modulation of complement regulatory proteins DAF (CD55) and MCP (CD46) in relation to the pathophysiology and clinical disease activity of rheumatoid arthritis

 

RESEARCH & IMPORTANT PUBLICATIONS

a. Research interests –

Genetic, biochemical and immunological studies to gain insight into the pathophysiology, susceptibility and risk factors for coronary artery disease (HDL-associated paraoxonase; apo A4, antioxidants, nitric oxide synthase, free radicals, cell adhesion molecules,  and nitric oxide). Modulation of complement regulatory proteins in autoimmune disorders like SLE and RA and significance of complement regulatory proteins as disease markers. The most recent study aims at elucidating the interplay between cytokines and complement regulatory proteins in autoimmune disorders. The projects under submission  relate to genetic and biochemical determinants of homocysteinemia and CAD; complement activation pathways and MASP2 in relation to immunoinflammatory mechanisms of CAD. Interested in Research and innovations in the area of Medical Education .

 

b. Ten Important Publications in last five years

 

  1. V Arora, R Grover, A Kumar, D Anand and N Das .Relationship of leucocyte complement receptor 1 transcript and protein with the pathophysiology and prognosis of systemic lupus erythematosus: a follow up study. Lupus. 0961203311400112, first published on June 9, 2011. doi:10.1177/0961203311400112

 

  1. Raini Dutta, Nibhriti Das. Immunomodulation of serum complement (C3) and macrophages by synthetic pyrethroid fenvalerate: In vitro study. 2011. Toxicology 285: 126–132.

 

  1. Imteyaz Ahmad, Rajiv Narang, Anand Venkatraman, Nibhriti Das. Frequency distribution of the Single-Nucleotide -108C/T Polymorphism at the Promoter region of the PON1 gene in Asian Indians and its relationship with coronary artery disease. Journal of Community Genetics. 2010.  2:27–32

 

  1. Rohan Khera & Nibhriti Das. Complement Receptor 1: Disease Associations and Therapeutic Implications. Molecular Immunology. 2009. 46: 761-772.

 

  1. Raini Dutta, Abdul Matin Mondal, Vaishali Arora, TC Nag and Nibhriti Das. Immunomodulatory effect of DDT (bis[4-chlorophenyl]-1,1,1-trichloroethane on complement system and macrophages. 2008. Toxocology. 252 (1-3): 78-85.

 

  1. Kamna Srivastava, Rajiv Narang, V. Sreeniwas, Sabari Das & Nibhriti Das. Association of eNOS Glu298Asp Gene polymorphism with essential hypertension in Asian Indians.2008. Clinica Chemica Acta. 387: 80.83

 

  1. Monika Gandhi, S.C. Tiwari, Ashok Kumar, A.K. Dinda  & Nibhriti Das. Plasma C3d: Potential marker for disease activity in Glomerulonephritis patients. 2007. The Icfai Journal of Biotechnology. 1: 7-14.

 

  1. Karthikeyan G., Baalasubramanian S., Seth S., Das N. Low levels of plasma soluble complement receptor type 1 in patients receiving thrombolytic therapy for acute myocardial infarction. 2007. J Thromb Thrombolysis. 23: 115-20.

 

  1. Vaishali Arora, Abdul Matin Mandal, Rahul Grover, Ashok Kumar, Parthaprasad Chattopadhyay & Nibhriti Das. 2007. Modulation of complement receptor 1 transcript in systemic lupus erythematosus by interferon gamma and immune complex.. Molecular Immunol. 44: 1722-1728.

 

  1. K Srivastava, R Narang, S Das, N Das. 2006. Nitric oxide and cell adhesion molecules in essential hypertension: a case control study. Journal of Human Hypertension. July; 20 (7): 537-9